Fmoc-L-Lys[C20-OtBu-Glu(OtBu)-AEEA-AEE A]-OH

Fmoc-L-Lys[C20-OtBu-Glu(OtBu)-AEEA-AEE A]-OH

Fmoc-L-Lys[C20-OtBu-Glu(OtBu)-AEEA-AEEA]-OH is a specialized SPPS building block for peptide synthesis. It features an Fmoc-protected lysine with its side chain pre-attached to a complex C20 fatty acid side chain. This enables the direct, site-specific incorporation of lipid modifications during automated peptide synthesis, primarily for producing drugs like Tirzepatide. It is essential for peptide API manufacturers and drug discovery R&D in the biopharmaceutical industry.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Fmoc – L – Lys[C₂₀ – OtBu – Glu(OtBu) – AEEA – AEEA] – OH
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	\
Molecular Weight	\
Amino Acid Sequence	C₂₀ – OtBu – Glu(OtBu) – AEEA – AEEA
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in common peptide – soluble solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO)
Endotoxin	< 1.0 EU/mg
Biological Activity	As a modified lysine – containing peptide, it may be involved in various biological processes related to lysine – dependent functions. Specific activity depends on the intended application, such as in peptide – based drug discovery, biomaterials research or protein – peptide interaction studies.
Storage Conditions	Store at – 20°C in a dry, inert gas (such as nitrogen) – filled environment. Protect from light and moisture. Avoid repeated freeze – thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Fmoc-L-Lys[C20-OtBu-Glu(OtBu)-AEEA-AEEA]-OH is a long-chain fatty acid-modified lysine derivative designed for lipidated peptide synthesis in drug discovery and bioconjugate development. The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the α-amino group, enabling selective deprotection during solid-phase peptide synthesis (SPPS). The ε-amino group of lysine is extended with a C20 fatty acid chain terminated with a tert-butyl ester (OtBu) protecting group, followed by a glutamic acid (Glu) unit also protected with OtBu, and two AEEA (8-amino-3,6-dioxaoctanoic acid) linkers.

This structure allows the attachment of a long hydrophobic tail to peptides, enhancing membrane permeability, serum stability, and targeting properties in biological systems. During synthesis, the Fmoc group is removed under mild basic conditions (piperidine), exposing the α-amino group for sequential coupling. The OtBu esters remain intact until final acidic global deprotection (commonly with TFA), releasing the free carboxylic acids for conjugation or further modifications. This modular protection strategy ensures precise control over peptide sequence and lipidation pattern.

2.PRODUCT INDICATIONS

Primary Synthetic Target:

Used as a building block for lipidated peptide synthesis, especially for GLP-1 analogs, long-acting peptide drugs, and conjugated peptide therapeutics.

Peptide Drug Applications:

Incorporation into peptides requiring prolonged half-life and improved bioavailability via albumin binding or fatty acid-mediated stabilization.

Ideal for developing once-weekly injectable peptide formulations.

Research & Development Uses:

Preclinical studies on structure-activity relationships (SAR) of lipidated peptides.

Synthesis of peptide-drug conjugates (PDCs) and targeted peptide therapeutics.

Industrial Applications:

Manufacturing of biopharmaceutical peptides with enhanced pharmacokinetics for metabolic diseases, oncology, and rare diseases.

3.CLINICAL EFFICACY OF PRODUCT

Item	Specification
Product Name	Fmoc – L – Lys[C₂₀ – OtBu – Glu(OtBu) – AEEA – AEEA] – OH
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	\
Molecular Weight	\
Amino Acid Sequence	C₂₀ – OtBu – Glu(OtBu) – AEEA – AEEA
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in common peptide – soluble solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO)
Endotoxin	< 1.0 EU/mg
Biological Activity	As a modified lysine – containing peptide, it may be involved in various biological processes related to lysine – dependent functions. Specific activity depends on the intended application, such as in peptide – based drug discovery, biomaterials research or protein – peptide interaction studies.
Storage Conditions	Store at – 20°C in a dry, inert gas (such as nitrogen) – filled environment. Protect from light and moisture. Avoid repeated freeze – thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

2.PRODUCT INDICATIONS

Primary Synthetic Target:

Used as a building block for lipidated peptide synthesis, especially for GLP-1 analogs, long-acting peptide drugs, and conjugated peptide therapeutics.

Peptide Drug Applications:

Incorporation into peptides requiring prolonged half-life and improved bioavailability via albumin binding or fatty acid-mediated stabilization.

Ideal for developing once-weekly injectable peptide formulations.

Research & Development Uses:

Preclinical studies on structure-activity relationships (SAR) of lipidated peptides.

Synthesis of peptide-drug conjugates (PDCs) and targeted peptide therapeutics.

Industrial Applications:

Manufacturing of biopharmaceutical peptides with enhanced pharmacokinetics for metabolic diseases, oncology, and rare diseases.

3.CLINICAL EFFICACY OF PRODUCT

Synthesis Efficiency:

High coupling yields (>95%) achieved in SPPS protocols using this lipidated lysine derivative, minimizing deletion and truncation byproducts.

Purity & Quality:

RP-HPLC purity typically ≥95%, ensuring reliable downstream peptide quality.

Residual protecting-group levels below pharmacopoeial limits after global deprotection.

Stability:

Stable under recommended storage (−20 °C, dry, inert atmosphere); shelf life exceeds 24 months when sealed properly.

Scalability:

Successfully scaled from milligram to multi-gram batches for preclinical peptide candidate production.

Safety Profile:

Non-toxic under standard laboratory handling; follow standard PPE protocols due to organic solvent use during synthesis.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.