Ac-[Tyr1,D-Arg2]-GRF (1-29) amide (human) COS NO.93942-91-7

Ac-[Tyr1,D-Arg2]-GRF (1-29) amide (human) (CAS NO. 93942-91-7) is a modified 29-amino-acid peptide with the molecular formula C₁₅₄H₂₅₅N₄₇O₄₃S and molecular weight 3485.1 g/mol. Engineered with N-terminal acetylation (Ac-Tyr¹) and D-arginine substitution (D-Arg²), it is a highly stable, potent agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), designed for robust growth hormone (GH) release studies and preclinical drug development.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Ac-[Tyr1,D-Arg2]-GRF (1-29) amide (human)
CAS NO.	93942-91-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₅₄H₂₅₅N₄₇O₄₃S
Molecular Weight	3485.1 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in neutral aqueous buffers (e.g., PBS, Tris-HCl pH 7.4); partially soluble in urea or guanidine hydrochloride (for denatured studies)
Endotoxin	< 1.0 EU/mg
Biological Activity	Modified human GRF (1-29) amide with N-terminal acetylation (Ac-Tyr¹) and D-arginine substitution (D-Arg²). Acts as a potent, stable agonist of the growth hormone secretagogue receptor 1a (GHS-R1a; human, EC₅₀: 0.05–0.5 nM). Enhanced resistance to proteases and improved receptor binding compared to native GRF (1-29). Stimulates growth hormone (GH) release from the anterior pituitary.
Storage Conditions	Store at -20°C in a tightly sealed, light-protected container; avoid moisture and repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GHS-R1a Activation: Binds to the growth hormone secretagogue receptor 1a (GHS-R1a) with high affinity (human, EC₅₀: 0.05–0.5 nM), triggering Gq/11 protein-coupled signaling cascades.

Enhanced Stability: N-terminal acetylation (Ac-Tyr¹) and D-Arg² substitution resist proteolytic degradation, extending half-life in biological fluids compared to native GRF (1-29).

GH Secretion: Stimulates growth hormone release from the anterior pituitary via GHS-R1a-mediated Ca²⁺ influx and cAMP elevation, bypassing hypothalamic somatostatin inhibition.

2.PRODUCT INDICATIONS

Endocrinology Research: Studying GH regulation, puberty, aging-related hormonal changes, and GH deficiency disorders.

Preclinical Drug Development: Screening GHS-R1a agonists/antagonists for treating growth disorders (e.g., dwarfism) or metabolic diseases (e.g., cachexia).

Long-Term In Vivo Studies: Investigating sustained GH secretion in animal models, leveraging the peptide’s enhanced stability.

3.CLINICAL EFFICACY OF PRODUCT

GH Secretion: In human pituitary cell cultures, it increased GH release by 6–12x (1 nM concentration) vs. baseline, outperforming native GRF (1-29) by 20–30%.

Linear Growth: In GH-deficient rodent models, it promoted 40–60% greater body length increase over 8 weeks vs. untreated controls, with 15–25% higher efficacy than unmodified GRF.

Stability in Vivo: In rat plasma, it retained 80% of initial activity after 24 hours (vs. 30% for native GRF), enabling longer-duration studies.

4.DELIVERY & SHIPPING

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