[Lys0] g-1-MSH, amide

[Lys0] γ-1-MSH, amide is a synthetic, modified analog of the gamma-1 melanocyte-stimulating hormone (γ1-MSH). This research-grade peptide features an additional lysine residue at the N-terminus (position 0) and C-terminal amidation. These modifications are designed to enhance solubility, potentially alter receptor interaction profiles, and improve metabolic stability, making it a specialized tool for investigating the nuanced roles of γ-MSH peptides, particularly in cardiovascular and adrenal regulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Lys⁰]-γ₁-MSH, amide (Lysine⁰-gamma-1-Melanocyte Stimulating Hormone, amide)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C78H109N23O15S
Molecular Weight	1640.95g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥30 mg/mL), dilute acetic acid, or 5% DMSO in water
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of melanocortin receptors (MC1R, MC3R, MC5R); regulates pigmentation, energy homeostasis, and anti-inflammatory responses.
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog functions as a melanocortin receptor agonist. The addition of the N-terminal lysine ([Lys0]) may influence its charge and interaction with melanocortin receptors, primarily targeting the melanocortin 3 receptor (MC3R). C-terminal amidation increases resistance to carboxypeptidase degradation, prolonging its activity. Upon receptor binding, it stimulates adenylate cyclase, increasing intracellular cAMP levels to modulate physiological processes such as aldosterone secretion from the adrenal cortex, blood pressure, and potentially inflammatory responses.

2.PRODUCT INDICATIONS

This product is indicated for advanced research in endocrinology, cardiovascular physiology, and receptor pharmacology. Key applications include: studying the specific functions of γ-MSH peptides and MC3R in cardiovascular homeostasis and adrenal steroidogenesis, investigating hypertension and electrolyte balance models, serving as a modified ligand in structure-activity relationship (SAR) studies of melanocortin peptides, and exploring central and peripheral roles of MC3R signaling.

3.CLINICAL EFFICACY OF PRODUCT

[Lys0] γ-1-MSH, amide is a research compound, not a clinical therapeutic. Its efficacy is demonstrated in the laboratory as a specialized probe. Research using such modified γ-MSH analogs has been critical in elucidating the unique role of the γ-MSH/MC3R axis in regulating aldosterone release and blood pressure, independent of the classical renin-angiotensin system. These findings highlight a potential novel pathway for therapeutic intervention in conditions like hypertension and primary aldosteronism.

4.DELIVERY & SHIPPING

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