[Ac-Cys4,DPhe7,Cys10] a-MSH (4-13), amide CAS NO.91050-39-4

[Ac-Cys⁴, D-Phe⁷, Cys¹⁰] α-MSH (4-13), amide is a synthetic cyclic peptide analog derived from the core active fragment of α-melanocyte stimulating hormone, featuring specific modifications including N-terminal acetylation, D-Phe⁷ substitution, and a disulfide bridge between Cys⁴ and Cys¹⁰ to stabilize the bioactive conformation. This research-grade reagent is designed as a potent and selective agonist for melanocortin receptors, with enhanced metabolic stability and receptor binding affinity compared to the native peptide. The product is provided as a lyophilized powder with high purity and is intended for preclinical research applications in dermatology, metabolic disorders, and neuroimmunology, serving as a valuable pharmacological tool for investigating melanocortin receptor signaling pathways in both academic and pharmaceutical research settings.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Ac-Cys4,DPhe7,Cys10] a-MSH (4-13), amide
CAS NO.	91050-39-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C61H88N18O13S2
Molecular Weight	1345.61 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, physiological saline, dilute acetic acid or trace amounts of DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	This product is a cyclized analog of α-melanocyte-stimulating hormone (α-MSH), whose active conformation is stabilized by disulfide bonds. It primarily acts as a high-affinity agonist of melanocortin receptors (especially MC1R and MC4R). Its biological activity is typically verified through in vitro cAMP accumulation assays (e.g., using cell models expressing human MC1R or MC4R) or in vivo skin melanin production models. The introduction of D-Phe⁷ significantly enhances its receptor binding affinity and in vivo stability.
Storage Conditions	Freeze-dried powder: Store at -20°C or lower in a dry, light-protected environment for extended periods (recommended shelf life ≥ 2 years).
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The mechanism of action involves binding to and activating melanocortin receptors, primarily MC1R and MC4R, with high affinity and selectivity. Receptor engagement triggers Gαs protein-coupled signaling, leading to intracellular cAMP accumulation and activation of downstream pathways that regulate melanin synthesis in melanocytes, appetite regulation in the central nervous system, and modulation of inflammatory responses. The cyclic structure stabilized by the disulfide bridge between Cys⁴ and Cys¹⁰ maintains the peptide in its active conformation, while the D-Phe⁷ substitution enhances receptor binding affinity and resistance to enzymatic degradation, collectively resulting in prolonged biological activity and improved receptor selectivity compared to linear α-MSH analogs.

2.PRODUCT INDICATIONS

This cyclic α-MSH analog is indicated for research use only in preclinical studies investigating melanocortin receptor biology, skin pigmentation mechanisms, obesity and metabolic disorders, appetite regulation, and inflammatory processes. It serves as a potent agonist in receptor binding assays, functional assays measuring cAMP production, and animal models of pigmentation disorders, metabolic syndrome, and energy homeostasis. The product is also used in structure-activity relationship studies to understand ligand-receptor interactions and in the development of novel therapeutic compounds targeting melanocortin pathways. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals, and should be handled by trained research personnel in appropriate laboratory settings.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, [Ac-Cys⁴, D-Phe⁷, Cys¹⁰] α-MSH (4-13), amide does not have established clinical efficacy for therapeutic use in human patients. While this cyclic peptide analog and related compounds have been studied in preclinical models to understand melanocortin receptor physiology and potential therapeutic applications, the product itself has not undergone clinical development or received regulatory approval for any medical indication. Research using this peptide has contributed to the understanding of melanocortin signaling pathways and the identification of potential drug targets, but the product remains an investigational research tool without proven clinical efficacy or safety profile for human use.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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