![[Ac-Cys4,DPhe7,Cys10] a-MSH (4-13), amide CAS NO.91050-39-4](https://images.cnmqh.com/images/a10134/36109b347f0d2e2801d02c3be371f509-20260129060826.webp "[Ac-Cys4,DPhe7,Cys10] a-MSH (4-13), amide CAS NO.91050-39-4")
[Ac-Cys4,DPhe7,Cys10] a-MSH (4-13), amide CAS NO.91050-39-4
[Ac-Cys4,DPhe7,Cys10] a-MSH (4-13), amide CAS NO.91050-39-4
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Ac-Cys4,DPhe7,Cys10] a-MSH (4-13), amide |
| CAS NO. | 91050-39-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C61H88N18O13S2 |
| Molecular Weight | 1345.61 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, physiological saline, dilute acetic acid or trace amounts of DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | This product is a cyclized analog of α-melanocyte-stimulating hormone (α-MSH), whose active conformation is stabilized by disulfide bonds. It primarily acts as a high-affinity agonist of melanocortin receptors (especially MC1R and MC4R). Its biological activity is typically verified through in vitro cAMP accumulation assays (e.g., using cell models expressing human MC1R or MC4R) or in vivo skin melanin production models. The introduction of D-Phe⁷ significantly enhances its receptor binding affinity and in vivo stability. |
| Storage Conditions | Freeze-dried powder: Store at -20°C or lower in a dry, light-protected environment for extended periods (recommended shelf life ≥ 2 years). |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The mechanism of action involves binding to and activating melanocortin receptors, primarily MC1R and MC4R, with high affinity and selectivity. Receptor engagement triggers Gαs protein-coupled signaling, leading to intracellular cAMP accumulation and activation of downstream pathways that regulate melanin synthesis in melanocytes, appetite regulation in the central nervous system, and modulation of inflammatory responses. The cyclic structure stabilized by the disulfide bridge between Cys⁴ and Cys¹⁰ maintains the peptide in its active conformation, while the D-Phe⁷ substitution enhances receptor binding affinity and resistance to enzymatic degradation, collectively resulting in prolonged biological activity and improved receptor selectivity compared to linear α-MSH analogs.
2.PRODUCT INDICATIONS
This cyclic α-MSH analog is indicated for research use only in preclinical studies investigating melanocortin receptor biology, skin pigmentation mechanisms, obesity and metabolic disorders, appetite regulation, and inflammatory processes. It serves as a potent agonist in receptor binding assays, functional assays measuring cAMP production, and animal models of pigmentation disorders, metabolic syndrome, and energy homeostasis. The product is also used in structure-activity relationship studies to understand ligand-receptor interactions and in the development of novel therapeutic compounds targeting melanocortin pathways. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals, and should be handled by trained research personnel in appropriate laboratory settings.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, [Ac-Cys⁴, D-Phe⁷, Cys¹⁰] α-MSH (4-13), amide does not have established clinical efficacy for therapeutic use in human patients. While this cyclic peptide analog and related compounds have been studied in preclinical models to understand melanocortin receptor physiology and potential therapeutic applications, the product itself has not undergone clinical development or received regulatory approval for any medical indication. Research using this peptide has contributed to the understanding of melanocortin signaling pathways and the identification of potential drug targets, but the product remains an investigational research tool without proven clinical efficacy or safety profile for human use.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight
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