![α-Melanocyte Stimulating Hormone, acetylated-[D-Val13] (11-13) (MSHa) CAS NO.137359-89-8](https://images.cnmqh.com/images/a10134/fcd803c82eb1073e63dafeecff11f626-20260129074600.webp "α-Melanocyte Stimulating Hormone, acetylated-[D-Val13] (11-13) (MSHa) CAS NO.137359-89-8")
α-Melanocyte Stimulating Hormone, acetylated-[D-Val13] (11-13) (MSHa) CAS NO.137359-89-8
α-Melanocyte Stimulating Hormone, acetylated-[D-Val13] (11-13) (MSHa) CAS NO.137359-89-8
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | α-Melanocyte Stimulating Hormone, acetylated-[D-Val13] (11-13) (MSHa) |
| CAS NO. | 137359-89-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C18H33N5O4 |
| Molecular Weight | 383.49g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, PBS, or dilute acetic acid. Dissolve in sterile water or 0.1% acetic acid for stock solution (1-5 mg/mL) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Melanocortin receptor agonists (especially those targeting MC1R and MC4R), D-Val13 modification can enhance enzyme stability and receptor binding selectivity; their activity can be verified by in vitro cAMP assays or melanin production experiments. |
| Storage Conditions | The lyophilized powder should be stored at -20°C or below in a dry, light-protected environment; after reconstitution, it should be aliquoted and stored frozen at ≤-20°C. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The mechanism of action involves binding to melanocortin receptors (primarily MC1R and MC4R) as an agonist, triggering intracellular signaling through Gαs protein coupling and cAMP accumulation. The N-terminal acetylation and D-Val13 substitution are structural modifications designed to enhance enzymatic stability by reducing proteolytic degradation, potentially prolonging the peptide's half-life in biological systems. These modifications may also influence receptor binding affinity and selectivity profile compared to the native α-MSH sequence. Upon receptor activation, the peptide initiates downstream signaling cascades that regulate melanogenesis in melanocytes, appetite regulation in the hypothalamus, and various peripheral metabolic processes, although the specific pharmacological characteristics of this modified analog require experimental characterization.
2.PRODUCT INDICATIONS
This MSHa analog is indicated for research use only in preclinical studies investigating melanocortin receptor pharmacology, structure-activity relationships of modified peptides, and the effects of D-amino acid substitutions and acetylation on peptide function and stability. It serves as a tool compound in receptor binding assays, functional cAMP assays, and comparative studies with other α-MSH analogs to understand how specific structural modifications influence receptor interaction, metabolic stability, and biological activity. The product is also used in studies exploring the development of modified peptide therapeutics targeting melanocortin pathways for potential applications in pigmentation disorders, metabolic diseases, or other conditions. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, α-Melanocyte Stimulating Hormone, acetylated-[D-Val13] (11-13) (MSHa) does not have established clinical efficacy for therapeutic use in human patients. This specific modified peptide analog has not undergone clinical development or received regulatory approval for any medical indication. While α-MSH and related melanocortin peptides have been studied in preclinical models and some clinical trials for various conditions, this particular analog with D-Val13 substitution and acetylation remains an investigational research tool used primarily for structure-activity relationship studies and basic science investigations. It has no proven clinical efficacy or safety profile for human use and is intended solely for laboratory research applications.
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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight
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