[Tyr5,D-Trp6,8,9,Arg-NH210]-Neurokinin A (4-10)

[Tyr⁵, D-Trp⁶,⁸,⁹, Arg-NH₂¹⁰]-Neurokinin A (4-10) is a synthetic, highly modified peptide analog derived from the active core of Neurokinin A (NKA). This research-grade compound incorporates multiple engineered substitutions—a tyrosine at position 5, three D-tryptophan residues at positions 6, 8, and 9, and a C-terminal arginine amide. These modifications collectively confer exceptional metabolic stability, potent receptor binding, and enhanced biological activity, making it a premier tool for investigating tachykinin receptor (primarily NK2) signaling and peptide engineering.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Tyr⁵,D-Trp⁶,⁸,⁹,Arg-NH₂¹⁰]-Neurokinin A (4-10)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C57H68N14O10
Molecular Weight	1109.3/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid and DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent, selective and metabolically stable agonist for neurokinin-2 (NK2) receptors.
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This multi-substituted analog is a potent agonist for tachykinin receptors, with high affinity for the Neurokinin 2 (NK2) receptor. The incorporation of three D-tryptophan residues provides remarkable resistance to proteolytic degradation, drastically prolonging its in vitro and in vivo half-life. The specific substitutions also optimize its interaction with the NK2 receptor binding pocket, leading to strong and sustained activation. Upon receptor binding, it stimulates the Gq protein pathway, activating phospholipase C (PLC), generating inositol trisphosphate (IP₃) and diacylglycerol (DAG), and ultimately causing a significant and prolonged increase in intracellular calcium that drives sustained smooth muscle contraction.

2.PRODUCT INDICATIONS

This product is indicated for advanced research in neuropharmacology, smooth muscle physiology, and peptide drug design. Key applications include: studying the effects of sustained NK2 receptor activation in models of bronchoconstriction, gastrointestinal motility, and urinary bladder function; evaluating the impact of D-amino acid substitutions on peptide stability, receptor selectivity, and potency; serving as a robust, degradation-resistant agonist in chronic or extended-duration functional tissue assays; and as a lead compound for structure-activity relationship (SAR) studies aimed at developing novel therapeutic tachykinin receptor ligands.

3.CLINICAL EFFICACY OF PRODUCT

[Tyr⁵, D-Trp⁶,⁸,⁹, Arg-NH₂¹⁰]-NKA (4-10) is a sophisticated research tool, not a clinical drug. Its efficacy lies in its role as a proof-of-concept molecule that demonstrates how strategic peptide engineering (e.g., D-amino acid incorporation) can overcome key limitations like rapid degradation. Studies utilizing this and similar analogs provide critical insights for designing stable, potent peptide therapeutics.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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