[Pro34]-Neuropeptide Y (porcine) CAS NO.125580-28-1

[Pro³⁴]-Neuropeptide Y (porcine) is a site-specific analog of porcine Neuropeptide Y featuring a proline substitution at position 34, supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels. This research-grade peptide retains high affinity for NPY receptors (Y1, Y2, Y4, Y5) while the Pro³⁴ modification alters receptor interaction profiles and potentially enhances structural stability, making it ideal for comparative studies of NPY receptor selectivity, ligand-receptor binding kinetics, and structure-activity relationships in appetite regulation, energy metabolism, and cardiovascular function research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Pro34]-Neuropeptide Y (porcine)
CAS NO.	125580-28-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C190H286N54O56
Molecular Weight	4222.7g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid (e.g., 0.1% v/v), or phosphate-buffered saline (PBS). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This analog is a modified version of porcine Neuropeptide Y with a Proline substitution at position 34. This modification may alter receptor binding affinity, selectivity, or metabolic stability compared to the native peptide. It is designed to act as an agonist at NPY receptors (primarily Y1, Y2, Y4, Y5, Y6), inhibiting adenylate cyclase via Gi/o protein coupling. Bioactivity should be validated in relevant NPY receptor binding or functional assays (e.g., cAMP inhibition).
Storage Conditions	Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Pro³⁴]-Neuropeptide Y functions as a potent NPY receptor agonist, binding to Y1, Y2, Y4, and Y5 receptor subtypes with altered affinity and selectivity profiles compared to native NPY due to the Pro³⁴ substitution. Upon receptor binding, it couples with Gi/o proteins to inhibit adenylate cyclase, reduce intracellular cAMP levels, and modulate potassium channel activity and calcium mobilization. This signaling cascade results in decreased neuronal excitability, altered neurotransmitter release, and physiological effects on appetite stimulation, energy homeostasis, and cardiovascular regulation, with the Pro³⁴ modification providing insights into receptor recognition and ligand specificity.

2.PRODUCT INDICATIONS

This porcine NPY analog is indicated exclusively for research applications focused on Neuropeptide Y receptor pharmacology and structure-activity relationship studies. It is employed in comparative NPY receptor binding assays to assess the impact of position 34 modifications, functional studies measuring cAMP inhibition and receptor selectivity profiling, appetite and feeding behavior research, energy metabolism investigations, and cardiovascular physiology studies. The product serves as a valuable tool for understanding NPY receptor-ligand interactions, screening receptor antagonists, and studying the structural determinants of NPY signaling in obesity, metabolic disorders, and autonomic regulation. It is not intended for diagnostic, therapeutic, or clinical use.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, [Pro³⁴]-Neuropeptide Y (porcine) has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of NPY receptor pharmacology and structure-activity relationships, and may inform the design of future therapeutic agents targeting NPY receptors for obesity, metabolic syndrome, or cardiovascular diseases, its utility remains confined to preclinical research. Any clinical translation would require development of entirely distinct therapeutic agents with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

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