Urotensin II , human CAS NO.251293-28-4

Urotensin II, human is a cyclic 11-amino acid peptide with a disulfide bond between Cys⁵ and Cys¹⁰ and C-terminal amidation, supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels. This research-grade peptide is the endogenous ligand for the urotensin II receptor (UT, GPR14) and is recognized as one of the most potent vasoactive peptides in mammals. It is designed for studies of cardiovascular function, vascular tone regulation, and cardiac remodeling in human-relevant in vitrosystems, serving as a critical tool for investigating the urotensin system's role in hypertension, heart failure, and vascular diseases.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Urotensin II , human
CAS NO.	251293-28-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C64H85N13O18S2
Molecular Weight	1388.6g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). For best results, first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Urotensin II is a potent vasoactive cyclic peptide and the most potent known vasoconstrictor. It binds with high affinity to the G‑protein coupled receptor UT (GPR14), primarily coupling to Gq/11 to stimulate phospholipase C, leading to increased intracellular calcium and vasoconstriction. It is also involved in cardiac remodeling, fibrosis, and inflammation. Bioactivity is typically confirmed by vasoconstriction assays in isolated vessels or calcium mobilization assays in UT‑expressing cells.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Urotensin II, human exerts its biological effects by binding with high affinity to the G protein-coupled receptor UT (GPR14), primarily coupling to Gq/11 to activate phospholipase C and increase intracellular calcium mobilization. This signaling cascade leads to potent vasoconstriction in vascular smooth muscle cells and modulates cardiac contractility, fibrosis, and inflammatory responses. The peptide's cyclic structure is essential for receptor recognition and potency, and it exhibits minimal cross-reactivity with other vasoactive peptide receptors, making it a selective tool for studying UT-mediated pathways in cardiovascular physiology and pathology.

2.PRODUCT INDICATIONS

This peptide is indicated for research applications focused on cardiovascular biology, vascular tone regulation, and cardiac remodeling in human-relevant in vitrosystems. It is utilized in in vitroassays with UT-expressing cells to study calcium flux, vasoconstriction, and intracellular signaling pathways. The product also serves as a reference standard for receptor binding studies, autoradiography, and functional assays to investigate the role of the urotensin system in hypertension, pulmonary hypertension, heart failure, and vascular diseases, contributing to the understanding of UT as a therapeutic target.

3.CLINICAL EFFICACY OF PRODUCT

Urotensin II, human has no clinical efficacy or safety profile, as it is strictly a research reagent for preclinical investigations. The peptide has not undergone clinical trials, regulatory evaluation, or safety assessment for diagnostic or therapeutic use in humans. While preclinical studies demonstrate its potent vasoconstrictor and pro-fibrotic effects in cardiovascular models, these findings remain exploratory and have not been translated into validated clinical interventions. Any potential therapeutic applications would require the development of UT antagonists or modulators with comprehensive pharmacokinetic and safety evaluations.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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