[Arg8,des-Gly-NH29]-Vasopressin CAS NO.37552-33-3

[Arg⁸,des-Gly-NH₂⁹]-Vasopressin (CAS NO. 37552-33-3) is a synthetic analog of arginine vasopressin (AVP). This research-grade peptide features two key modifications: it retains the critical arginine at position 8 but lacks the C-terminal glycinamide residue (position 9). This C-terminal truncation results in a peptide with a significantly altered pharmacological profile, primarily functioning as a potent and selective vasopressin V1a receptor antagonist.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Arg8,des-Gly-NH₂⁹]-Vasopressin
CAS NO.	37552-33-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C44H61N13O12S2
Molecular Weight	1028.18/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥20 mg/mL), dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Selective agonist for vasopressin V1 receptors; exhibits potent vasopressor activity without significant antidiuretic effect
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog acts primarily as a competitive antagonist at the vasopressin V1a receptor. The removal of the C-terminal glycinamide (des-Gly-NH₂⁹) drastically reduces or eliminates its agonist activity at the V2 receptor while preserving high affinity for the V1a subtype. By binding to the V1a receptor without activating it, it effectively blocks the action of endogenous vasopressin, inhibiting V1a-mediated physiological effects such as vasoconstriction, platelet aggregation, and glycogenolysis.

2.PRODUCT INDICATIONS

This product is indicated for specific research in cardiovascular physiology, hepatology, and receptor pharmacology where selective V1a receptor blockade is required. Key applications include: investigating the specific roles of V1a receptors in vascular tone, blood pressure regulation, and hepatic glucose metabolism; serving as a selective V1a antagonist control in studies of vasopressin's pressor effects; studying V1a receptor signaling pathways in isolation from V2 effects; and as a tool to differentiate between V1a and V2 receptor-mediated responses in vitro and in vivo.

3.CLINICAL EFFICACY OF PRODUCT

[Arg⁸,des-Gly-NH₂⁹]-Vasopressin is a research compound and not used directly in clinical therapy. However, its efficacy as a selective V1a receptor antagonist has made it an invaluable pharmacological tool. Research using this analog has been crucial in delineating the distinct physiological roles of V1a versus V2 receptors.

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