Helospectin I

Helospectin I is a 35-amino acid vasoactive intestinal peptide (VIP)-like neuropeptide isolated from Gila monster venom, with a molecular weight of approximately 4095.66g/mol and a complex disulfide-bonded tertiary structure essential for bioactivity. Supplied as a high-purity lyophilized powder, it serves as a potent research tool for studying VIP receptor signaling, smooth muscle relaxation, and neuroendocrine regulation. The peptide's unique sequence and structural features make it valuable for investigating vasodilation, gastrointestinal motility, and neuropeptide-receptor interactions in preclinical models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Helospectin I
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C183H293N47O59
Molecular Weight	4095.66g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Helospectin I is a vasoactive intestinal peptide (VIP)-like peptide isolated from the venom of the Gila monster. It acts as a potent agonist of VIP receptors (VPAC1/VPAC2), exhibiting vasodilatory, smooth‑muscle relaxant, and neuroendocrine regulatory activities. Bioactivity is typically confirmed by receptor binding assays or functional cAMP assays in VPAC‑expressing cells.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Helospectin I exerts its biological effects primarily through high-affinity agonist activity at VPAC1 and VPAC2 receptors, which are G protein-coupled receptors coupled to Gαs. Activation stimulates adenylate cyclase, increases intracellular cAMP levels, and activates protein kinase A, leading to smooth muscle relaxation, vasodilation, and modulation of neurotransmitter release. The peptide's disulfide-bonded structure is critical for receptor binding specificity and potency, distinguishing it from shorter VIP analogs and enabling detailed investigation of VIP receptor subtype signaling pathways and downstream physiological effects.

2.PRODUCT INDICATIONS

Helospectin I is indicated for research applications in cardiovascular physiology, gastrointestinal motility, neuroendocrinology, and VIP receptor pharmacology. It is used in in vitroassays such as receptor binding studies, cAMP accumulation assays, and smooth muscle relaxation experiments to characterize VPAC receptor activation and signaling. In in vivomodels, the peptide is administered to study its effects on blood pressure regulation, intestinal peristalsis, and neuroendocrine function, providing insights into VIP-mediated pathways and potential therapeutic targets for vascular and gastrointestinal disorders.

3.CLINICAL EFFICACY OF PRODUCT

Helospectin I has no established clinical efficacy, safety profile, or regulatory approval for human use. Preclinical studies have demonstrated its potent vasodilatory and smooth muscle relaxant effects in animal models, but these findings are exploratory and limited to basic research. No controlled clinical trials have been conducted to evaluate its therapeutic benefits, dosing regimens, or adverse effects in humans, and its translation to clinical applications is precluded by insufficient pharmacokinetic, toxicological, and long-term safety data. The peptide remains strictly a research reagent for investigative purposes without validated diagnostic or therapeutic indications.

4.DELIVERY & SHIPPING

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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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