Substance P (1-4) CAS NO.57468-16-3

Helospectin I is a VIP-like neuropeptide isolated from Gila monster venom, featuring a 35-amino acid sequence with multiple disulfide bonds that confer structural stability and biological potency. As a high-purity research-grade peptide, it serves as a valuable tool for investigating vasoactive intestinal peptide receptor signaling pathways, smooth muscle physiology, and neuroendocrine regulation in preclinical models, providing insights into cardiovascular and gastrointestinal function.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Substance P (1-4)
CAS NO.	57468-16-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C22H40N8O5
Molecular Weight	496.6g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Substance P (1-4) is the N-terminal tetrapeptide fragment of Substance P. It may exhibit partial or altered affinity for neurokinin receptors compared to the full-length peptide and is used primarily in structure-activity relationship studies and receptor mapping research.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Helospectin I functions as a potent agonist at VPAC1 and VPAC2 receptors, activating Gαs-coupled signaling that stimulates adenylate cyclase and elevates intracellular cAMP levels. This cascade activates protein kinase A, leading to phosphorylation of target proteins that induce smooth muscle relaxation, vasodilation, and modulation of neurotransmitter release. The peptide's disulfide-bonded tertiary structure is essential for high-affinity receptor binding and selective activation of VIP-mediated pathways.

2.PRODUCT INDICATIONS

This peptide is indicated for research applications in cardiovascular and gastrointestinal physiology, neuroendocrinology, and VIP receptor pharmacology. It is utilized in in vitroassays including receptor binding studies, cAMP accumulation measurements, and smooth muscle relaxation experiments to characterize VPAC receptor activation. In in vivomodels, Helospectin I is administered to study its effects on blood pressure regulation, intestinal motility, and neuroendocrine responses, contributing to understanding VIP-mediated physiological processes.

3.CLINICAL EFFICACY OF PRODUCT

Helospectin I has no established clinical efficacy or regulatory approval for human use. Preclinical studies demonstrate potent vasodilatory and smooth muscle relaxant effects in animal models, but these findings remain exploratory without controlled clinical trials. The peptide lacks comprehensive pharmacokinetic, toxicological, and long-term safety data required for therapeutic development, maintaining its status strictly as a research reagent for investigative purposes.

4.DELIVERY & SHIPPING

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