Substance P (7-11) CAS NO.51165-05-0

Substance P (7-11) (CAS NO. 51165-05-0) is a synthetic pentapeptide representing the C-terminal fragment (Phe-Phe-Gly-Leu-Met-NH₂) of the full-length neuropeptide Substance P. This high-purity, truncated sequence constitutes the minimal active core required for receptor binding and activation. It serves as a potent and selective agonist for the Neurokinin 1 (NK1) receptor and is a fundamental tool for tachykinin receptor research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Substance P (7-11)
CAS NO.	51165-05-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C31H44N6O5S
Molecular Weight	612.8/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥30 mg/mL), dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Tachykinin receptor agonist (high affinity for NK1 receptors); mediates smooth muscle contraction, pain signaling and neuroinflammatory responses.
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This pentapeptide acts as a potent and selective agonist for the Neurokinin 1 (NK1) receptor, the primary receptor for Substance P. The C-terminal pentapeptide sequence is the critical pharmacophore for NK1 receptor interaction. Upon binding, it activates the Gq protein-coupled signaling pathway, leading to phospholipase C (PLC) activation. This triggers the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP₂) into inositol trisphosphate (IP₃) and diacylglycerol (DAG), resulting in intracellular calcium mobilization and protein kinase C (PKC) activation.

2.PRODUCT INDICATIONS

This product is indicated for focused research in neuropharmacology, inflammation, and smooth muscle physiology. Key applications include: studying NK1 receptor-specific signaling and function without interference from other tachykinin receptors; investigating the role of the NK1 receptor in pain pathways, neurogenic inflammation, and emesis (vomiting); serving as a standard selective NK1 agonist in receptor binding assays and functional studies (e.g., calcium flux, smooth muscle contraction); and as a key compound for structure-activity relationship (SAR) studies of Substance P analogs.

3.CLINICAL EFFICACY OF PRODUCT

Substance P (7-11) is a research tool, not a direct clinical drug. However, its efficacy as a selective NK1 agonist has been pivotal in preclinical research. Studies using this fragment have been essential in delineating the specific biological roles of the NK1 receptor, separating them from effects mediated by NK2 or NK3 receptors. This foundational work directly validated the NK1 receptor as a high-value therapeutic target. The knowledge gained contributed significantly to the successful development and approval of NK1 receptor antagonists, such as aprepitant, for the prevention of chemotherapy-induced nausea and vomiting (CINV).

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