Amylin (IAPP)(Feline)

Amylin (IAPP) (Feline) is a synthetic peptide corresponding to the 37-amino acid sequence of the feline (cat) isoform of Islet Amyloid Polypeptide (IAPP). This research-grade peptide is the feline homolog of the human hormone amylin. It is co-secreted with insulin from pancreatic β-cells and plays a key role in glucose regulation. In cats, this peptide is of particular importance as it is the primary component of pancreatic islet amyloid, a hallmark pathological feature of feline diabetes mellitus. It is an essential tool for veterinary diabetes research and comparative studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Amylin (IAPP)(Feline)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₆₅H₂₇₀N₅₂O₅₄S₂
Molecular Weight	3910.45 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (5 mg/mL) or 5% acetic acid; also soluble in DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	A 37-amino acid regulatory peptide from feline pancreatic β-cells; inhibits insulin and glucagon secretion, delays gastric emptying, and can aggregate into pancreatic islet amyloid deposits in vitro.
Storage Conditions	-20°C for long-term storage (up to 2 years at -80°C, 1 year at -20°C); avoid repeated freeze-thaw cycles. Store as aliquots in sealed vials.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The physiological mechanism of feline amylin mirrors that of other species, but with critical differences in its pathological aggregation propensity:

Physiological Action (Similar to Human/Other Species): It binds to amylin receptors (CTR/RAMP complexes) to:
- Inhibit postprandial glucagon secretion.
- Slow gastric emptying.
- Promote satiety via central actions.
Pathological Aggregation (Species-Specific): The feline amylin amino acid sequence differs from the human sequence at key positions. These differences make it highly amyloidogenic. In diabetic cats, feline IAPP aggregates into insoluble amyloid fibrils within the pancreatic islets. This amyloid deposition is directly toxic to β-cells, contributing to:
- β-cell dysfunction and apoptosis.
- Progressive insulin deficiency.
- Exacerbation of diabetes.

through the inhibition of cAMP-dependent pathways and potential modulation of ion channels.

2.PRODUCT INDICATIONS

This product is specifically indicated for veterinary and comparative biomedical research. Key applications include:

Veterinary Diabetes Research: Studying the pathogenesis, progression, and pathology of spontaneous diabetes mellitus in cats, with a focus on islet amyloidosis.
Comparative Amyloidology: Investigating the structural and sequence determinants of amyloidogenicity by comparing feline, human, and other species' IAPP.
Drug Discovery for Feline Diabetes: Screening for compounds that inhibit feline IAPP aggregation or protect β-cells from its toxic effects, aiming to develop disease-modifying therapies for cats.
Pancreatic Islet Studies: Research on islet health, β-cell viability, and amyloid-induced inflammation in feline models.
Physiological Studies: Investigating the normal endocrine role of amylin in feline glucose homeostasis.

3.CLINICAL EFFICACY OF PRODUCT

Feline Amylin (IAPP) itself is not a therapeutic. Its "efficacy" is defined by its critical role as a pathological agent and research tool in understanding a major disease of domestic cats.

Validated Pathological Driver: Research has definitively established that the aggregation of feline IAPP is a primary contributor to β-cell loss and the development of diabetes in cats. This understanding is a cornerstone of modern feline diabetology.
Enables Targeted Research: Availability of this peptide allows for the development of in vitro and in vivo models of feline islet amyloidosis, which are essential for:
- Understanding disease mechanisms.
- Screening potential therapeutic agents (e.g., aggregation inhibitors) that could slow or prevent diabetes progression in cats.
Translational Potential: Insights gained from studying feline IAPP aggregation may also inform research into human type 2 diabetes and other amyloid diseases.
4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.