Procyanidin A2 CAS NO.41743-41-3

Procyanidin A2 is a highly potent natural flavanol dimer primarily sourced from cranberries, blueberries, and grape seeds, renowned for its exceptional antioxidant capacity that surpasses many synthetic alternatives. This compound exhibits a broad spectrum of biological activities, including significant anti-inflammatory, antibacterial, and anti-proliferative properties, making it a valuable ingredient for pharmaceutical research, nutraceutical development, and high-end cosmeceutical formulations aimed at combating oxidative stress and cellular damage.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Procyanidin A2
CAS NO.	41743-41-3
Appearance	Light yellow to off-white powder
Molecular Formula	C₃₀H₂₄O₁₂
Molecular Weight	576.50 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in methanol, DMSO, and water (limited solubility); insoluble in non-polar solvents
Endotoxin	Not applicable (plant-derived polyphenol)
Biological Activity	Potent antioxidant with strong free radical scavenging ability; exhibits anti-inflammatory, anti-cardiovascular disease, and anti-cancer properties in preclinical studies; modulates endothelial function and lipid metabolism
Storage Conditions	Store at 2–8°C, protected from light and moisture; avoid prolonged exposure to air
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The therapeutic effects of Procyanidin A2 are primarily mediated through the activation of the Nrf2/ARE signaling pathway, which upregulates key antioxidant enzymes like HO-1 and NQO1 to combat oxidative stress. Simultaneously, it inhibits the NF-κB and MAPK pathways, reducing the production of pro-inflammatory cytokines such as TNF-α, IL-6, and NO. Additionally, it demonstrates anti-proliferative effects by modulating the PI3K/AKT signaling cascade and inducing cell cycle arrest, thereby exerting its protective and therapeutic actions at the molecular level.

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2.PRODUCT INDICATIONS

Procyanidin A2 is ideally indicated for research and development in cardiovascular health, where it helps protect endothelial function and improve microcirculation. It shows great promise in neuroprotection, potentially slowing the progression of neurodegenerative diseases like Alzheimer's by mitigating neuroinflammation and oxidative damage. Furthermore, its application extends to oncology research for inhibiting cancer cell proliferation, as well as in skincare for developing anti-aging and anti-inflammatory formulations that protect against environmental stressors.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical studies have demonstrated that Procyanidin A2 significantly improves cognitive function and reduces pathological markers in models of Alzheimer's disease. In metabolic contexts, it alleviates diabetic retinopathy and cerebral ischemia by reducing inflammation and apoptosis. Experimental data also confirms its efficacy in inhibiting the growth and migration of various cancer cells, including prostate and liver carcinomas, while human trials support its role in enhancing vascular health and reducing oxidative damage associated with aging and chronic diseases.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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