Tofacitinib Citrate CAS NO.540737-29-9

Tofacitinib Citrate is a potent, selective JAK kinase inhibitor designed for research and therapeutic applications targeting immune-mediated inflammatory disorders. It offers high purity, excellent solubility, and consistent biological activity, making it a preferred choice for scientists studying autoimmune mechanisms, cytokine signaling, and drug development platforms.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Tofacitinib Citrate
CAS NO.	540737-29-9
Appearance	White to off-white crystalline powder
Molecular Formula	C₂₂H₂₈N₆O₈
Molecular Weight	504.49 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water, DMSO, and methanol; partially soluble in ethanol
Endotoxin	≤ 0.1 EU/mg (Suitable for in vitro and in vivo biological studies)
Biological Activity	JAK3-selective inhibitor; modulates cytokine signaling pathways involved in immune response and inflammation
Storage Conditions	Store at room temperature (15–30°C), protect from light and moisture; stable for 24–36 months when sealed properly
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Tofacitinib Citrate exerts its pharmacological effect by competitively inhibiting Janus kinase (JAK) enzymes, particularly JAK3, which are essential for transducing signals from multiple cytokines including interleukins and interferons. By blocking JAK-mediated phosphorylation of STAT proteins, it disrupts downstream inflammatory gene expression and immune cell activation, thereby reducing inflammation and autoimmunity without broadly suppressing global immune function.

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2.PRODUCT INDICATIONS

This compound is indicated for research applications involving rheumatoid arthritis, psoriasis, psoriatic arthritis, ulcerative colitis, and other immune-mediated inflammatory diseases. It is also used in preclinical models to evaluate JAK-STAT pathway inhibitors, cytokine modulation, and targeted immunotherapies for next-generation drug discovery.

3.CLINICAL EFFICACY OF PRODUCT

In clinical trials and preclinical models, Tofacitinib Citrate has demonstrated significant efficacy in reducing joint swelling, skin lesion severity, and systemic inflammation markers in patients with autoimmune conditions. Its ability to rapidly modulate immune responses and provide sustained symptom relief supports its use as a benchmark JAK inhibitor in both therapeutic and research settings.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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