Aristolochic acid C CAS NO.4849-90-5

Aristolochic acid C is a nitrophenanthrene carboxylic acid alkaloid derived from plants of the Aristolochiaceae family, typically supplied as a yellow to light brown crystalline solid intended strictly for controlled laboratory environments. As a defined derivative of aristolochic acid, this research chemical is characterized by its distinct structural profile featuring a nitro group and a phenanthrene core, making it a specialized reagent for scientists studying plant-derived toxins, alkaloid chemistry, and specific cellular inhibitory pathways. It is primarily targeted at toxicological researchers, natural product chemists, and pharmaceutical R&D professionals who require a high-purity reference standard to investigate the biological activities or detection methods of Aristolochia constituents in vitro.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Aristolochic acid C
CAS NO.	4849-90-5
Appearance	Yellow to light brown crystalline solid
Molecular Formula	C16H9NO7
Molecular Weight	327.25 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in DMSO, methanol; slightly soluble in ethanol
Endotoxin	≤10 EU/mg
Biological Activity	Phospholipase A2 (PLA2) inhibitor; Anti-proliferative activity against certain cancer cell lines
Storage Conditions	-20°C, protected from light, sealed and dry
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The biological activity of Aristolochic acid C is largely attributed to its capacity to act as a phospholipase A2 (PLA2) inhibitor, interfering with enzymatic processes that release arachidonic acid and subsequently modulate inflammatory responses and cellular signaling cascades. Additionally, it exhibits cytotoxic properties by interacting with DNA and inducing oxidative stress within cells, which can lead to cell cycle arrest and apoptosis in susceptible cancer cell lines. This dual mechanism involving enzyme inhibition and direct genotoxic effects provides a molecular basis for its potential role in studying anti-tumor activities and the toxicological mechanisms underlying aristolochic acid nephropathy in research settings.

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2.PRODUCT INDICATIONS

Aristolochic acid C is specifically indicated for use in scientific research applications focused on toxicology, pharmacology, and natural product chemistry, particularly for studies exploring the mechanisms of bioactivation of aristolochic acids and their associated nephrotoxic and carcinogenic risks. It serves as a critical reference standard for developing analytical methods to detect these compounds in herbal supplements and environmental samples, catering to researchers in academic institutions and regulatory agencies. Furthermore, it is suitable for in vitro screening assays aimed at evaluating the anti-proliferative effects of aristolochic acid derivatives on various human cancer cell lines, supporting exploratory investigations into potential therapeutic leads while emphasizing strict safety protocols.

3.CLINICAL EFFICACY OF PRODUCT

While Aristolochic acid C is not approved for clinical use due to significant safety concerns, including nephrotoxicity and carcinogenicity, its efficacy in a research context lies in its utility as a model compound for understanding the pathophysiology of aristolochic acid-induced diseases. Preclinical studies have demonstrated its ability to induce DNA damage and modulate cellular signaling pathways relevant to cancer progression, providing valuable insights into the molecular basis of its toxicity. These findings contribute to the broader knowledge base regarding the risks associated with aristolochic acid-containing herbal medicines and inform the development of strategies to mitigate exposure, rather than serving as a therapeutic agent for clinical applications.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

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