(R)-(-)-Rolipram CAS NO.85416-75-7

(R)-(-)-Rolipram is the highly active R-enantiomer of the well-known compound rolipram, supplied as a high-purity white to off-white crystalline powder specifically for non-clinical laboratory research and chemical assay use. As a potent and selective inhibitor of phosphodiesterase-4 (PDE4), it serves as a critical pharmacological tool for scientists investigating intracellular cAMP signaling pathways, neurobiology, and inflammatory responses. This research-grade chemical is ideal for academic institutions, biotechnology companies, and pharmaceutical R&D departments looking to study CNS disorders, respiratory inflammation, or to use as a standard reference in drug discovery screens targeting PDE4 enzymes.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	(R)-(-)-Rolipram
CAS NO.	85416-75-7
Appearance	White to off – white crystalline powder
Molecular Formula	C16H21NO3
Molecular Weight	275.34 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in DMSO, chloroform, absolute alcohol; slightly soluble in oil
Endotoxin	≤ 5 EU/mg
Biological Activity	Potent, selective PDE4 inhibitor; exhibits anti-inflammatory and neuroprotective effects in vitro and in vivo
Storage Conditions	Store at -20°C, protected from light and moisture; stable for 24 months when stored properly
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The primary mechanism of (R)-(-)-Rolipram involves the highly specific inhibition of the phosphodiesterase-4 (PDE4) enzyme family, which is responsible for the hydrolysis of cyclic adenosine monophosphate (cAMP) to 5'-AMP in cells. By blocking PDE4 activity, the compound effectively prevents the breakdown of cAMP, leading to an elevated and sustained concentration of intracellular cAMP levels, particularly in immune cells like macrophages and microglia as well as neurons. This increase in cAMP subsequently activates protein kinase A (PKA) and Exchange Proteins Activated by cAMP (EPAC), which in turn downregulates the expression of pro-inflammatory cytokines (such as TNF-α and IL-6) and modulates various downstream signaling cascades related to cell survival, differentiation, and inflammatory mediator release.

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2.PRODUCT INDICATIONS

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3.CLINICAL EFFICACY OF PRODUCT

This product is indicated strictly for in vitro and in vivo preclinical research applications, targeting qualified researchers studying neurological and psychiatric disorders, including depression, anxiety, Alzheimer’s disease, and Parkinson’s disease, as well as inflammatory conditions like asthma, COPD, and autoimmune diseases. It is particularly useful for neuroscientists exploring synaptic plasticity, long-term memory formation, and myelin repair, as well as immunologists investigating the suppression of leukocyte function and cytokine storms. Additionally, it serves as a vital chemical probe for formulators and medicinal chemists developing next-generation PDE4 inhibitors with improved therapeutic profiles, and is applicable for use in cell-based high-throughput screening assays and receptor binding studies.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: PDE4 Inhibitor, R-enantiomer, cAMP Modulator, Neuroinflammation, Cognitive Research, Anti-inflammatory, Research Chemical, Pyrolidinone, Phosphodiesterase, Drug Discovery Tool.

If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157