Chlorpromazine CAS NO.50-53-3

Chlorpromazine is a first-generation antipsychotic agent belonging to the phenothiazine class, widely utilized in both clinical and research settings for its ability to modulate neurotransmission. It serves as a valuable tool for studying dopaminergic and serotonergic pathways, offering researchers a well-characterized compound for investigating the pathophysiology of psychiatric disorders and related neurological conditions. Its stability and consistent activity make it suitable for a wide range of in vitro and in vivo experimental applications.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Chlorpromazine
CAS NO.	50-53-3
Appearance	White to off-white crystalline powder
Molecular Formula	C₁₇H₁₉ClN₂S
Molecular Weight	318.86 g/mol
Amino Acid Sequence	Not applicable
Purity (RP-HPLC)	≥98.5%
Solubility	Soluble in water, ethanol, and chloroform; slightly soluble in ether
Endotoxin	< 1 EU/mg
Biological Activity	Antipsychotic, antiemetic, antihistaminic, and anticholinergic activities; dopamine D2 receptor antagonist
Storage Conditions	Store at room temperature (15-30°C), protected from light and moisture
Stock Location	USA / Germany / China (optional, based on actual stock)
MOQ	1 g

1.Mechanism of Action

Chlorpromazine exerts its therapeutic effects primarily by antagonizing dopamine D2 receptors in the brain, particularly within the mesolimbic and nigrostriatal pathways, which helps alleviate positive symptoms of psychosis. Additionally, it blocks muscarinic acetylcholine receptors, alpha-adrenergic receptors, and histamine H1 receptors, contributing to its broad pharmacological profile, including sedation, hypotension, and anticholinergic side effects. This multi-receptor interaction underpins its use not only in schizophrenia and bipolar disorder but also in managing severe nausea, vomiting, and intractable hiccups through its central and peripheral antiemetic actions.

2.Product Indications

This compound is indicated for research purposes aimed at exploring treatments for schizophrenia, schizoaffective disorder, manic episodes in bipolar disorder, and severe behavioral problems in children and adults. It is also employed in scientific studies investigating its efficacy in controlling nausea and vomiting associated with surgery, cancer chemotherapy, or radiation therapy, as well as in managing intractable hiccups and tetanus. Researchers utilize it to develop novel therapeutics targeting neurotransmitter imbalances and to evaluate its potential in adjunctive cancer therapy due to its immune-modulating and cytotoxic properties observed in preclinical models.

3.Clinical Efficacy of Product

Chlorpromazine has demonstrated significant efficacy in reducing psychotic symptoms such as hallucinations, delusions, and disorganized thinking, establishing itself as a cornerstone in the pharmacological management of schizophrenia since its introduction. In clinical settings, it effectively controls acute agitation and aggression, while its antiemetic properties provide rapid relief from severe nausea and vomiting unresponsive to other agents. Although largely superseded by newer atypical antipsychotics in long-term care due to side effect profiles, its robust efficacy in acute presentations and specific indications like tetanus-related muscle spasms underscores its enduring value in both historical context and modern research focused on optimizing dosing strategies and minimizing adverse effects.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

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Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

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Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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