Calcitonin, porcine CAS NO.12321-44-7

Calcitonin, porcine is a highly purified, 32-amino acid polypeptide hormone naturally synthesized by the thyroid C-cells of pigs, supplied as a sterile lyophilized white powder for advanced endocrinological and osteological research. Structurally characterized by a disulfide bridge between Cys1 and Cys7 and a C-terminal proline amide, this peptide shares high sequence homology with human calcitonin, making it a vital tool for scientists studying calcium homeostasis, bone metabolism, and G-protein-coupled receptor (GPCR) signaling. Its well-defined conformation and specific biological activity make it an essential reference standard for pharmaceutical R&D, biochemical laboratories, and academic institutions focused on antiresorptive drug discovery, hypercalcemia mechanisms, and the comparative physiology of calcitonin receptors across mammalian species.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Calcitonin, porcine
CAS NO.	12321-44-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C159H232N46O45S3
Molecular Weight	3604.1 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Soluble in water or 1% acetic acid; insoluble in common organic solvents
Endotoxin	≤0.5 EU/mg
Biological Activity	Acts as a calcitonin receptor agonist (GPCR); inhibits osteoclast-mediated bone resorption; promotes renal calcium excretion; used to study hypercalcemia, osteoporosis, and bone turnover markers
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1kit

1.MECHANISM OF ACTION

The primary biological mechanism of Calcitonin, porcine involves its specific binding to and activation of calcitonin receptors (CTR), which are class B G-protein-coupled receptors predominantly expressed on the surface of osteoclasts, renal tubular cells, and certain central nervous system neurons. Upon ligand engagement, the receptor undergoes a conformational change that preferentially couples to Gs proteins, stimulating the activity of adenylate cyclase to increase intracellular cyclic AMP (cAMP) levels, while also potentially engaging Gq proteins to activate the phospholipase C (PLC) beta isoform and elevate inositol triphosphate (IP3). This dual signaling cascade leads to the inhibition of osteoclast motility and ruffled border formation, effectively suppressing bone resorption and reducing the release of calcium and phosphate from the bone matrix into the bloodstream. Concurrently, the activation of CTR in the kidney promotes the excretion of calcium and phosphate by decreasing their reabsorption in the proximal tubules, thereby contributing to the rapid normalization of serum calcium levels through combined skeletal and renal pathways.

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2.PRODUCT INDICATIONS

This product is specifically indicated for in vitro laboratory research, receptor binding assays, and preclinical pharmacological studies centered on calcium regulation and bone remodeling disorders. It serves as a primary pharmacological standard for evaluating the potency and binding affinity of calcitonin receptor agonists, often utilized in competitive radioligand binding assays, cAMP accumulation assays using isolated osteoclasts or transfected cell lines, and bone marrow culture systems to assess antiresorptive activity. Researchers employ Calcitonin, porcine to investigate the structure-activity relationships of calcitonin analogs, to compare the differential signaling profiles between human, salmon, and porcine calcitonins, and to study the cellular mechanisms of bone metastasis and hypercalcemia induced by malignant tumors. Furthermore, it is indicated for use in isolated organ perfusion studies to assess renal handling of electrolytes, for pain research examining the central analgesic effects of calcitonins, and as a calibrated reagent in drug discovery pipelines aiming to develop novel therapeutics for osteoporosis, Paget's disease, and malignancy-associated hypercalcemia.

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3.CLINICAL EFFICACY OF PRODUCT

Although Calcitonin, porcine is strictly designated for research use and is not a clinical therapeutic agent in most contemporary settings, extensive in vitro and historical clinical studies have validated its significant efficacy in lowering serum calcium and inhibiting bone resorption. Laboratory evaluations confirm that it acts as a potent inhibitor of 1,25-dihydroxyvitamin D3-stimulated osteoclast differentiation and bone resorption, functioning through the targeted disruption of the actin cytoskeleton in osteoclasts to cease bone degradation at nanomolar concentrations. Preclinical and early clinical research demonstrated that parenteral administration of porcine calcitonin effectively reduced elevated serum calcium levels in patients with hypercalcemia of malignancy and provided symptomatic relief from bone pain in conditions like Paget's disease and osteoporosis, although its potency is notably lower (approximately 1/20th to 1/50th) compared to salmon calcitonin. These findings underscore the efficacy of Calcitonin, porcine as a reliable research reagent for dissecting the fundamental pharmacology of the calcitonin system, validating assay conditions for CTR ligand screening, and providing a mammalian-specific template for understanding species variations in hormone-receptor interactions.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags:Calcitonin porcine, Porcine Calcitonin, Peptide Hormone, Calcitonin Receptor Agonist, Calcium Homeostasis, Bone Metabolism, Antiresorptive, Osteoporosis Research.

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