Transdermal Peptide CAS No.888486-23-5

Transdermal Peptide (commonly referred to as TD-1) is a specialized 11-amino acid cyclic peptide specifically engineered as a high-efficiency penetration enhancer for pharmaceutical, cosmetic, and biochemical research sectors. It is primarily utilized by formulation scientists and dermatological researchers who require a non-invasive, biological method to transport hydrophilic macromolecules—such as proteins, insulin, growth hormones, and siRNA—across the highly restrictive stratum corneum barrier. Supplied as a high-purity white to off-white lyophilized powder strictly for in vitro and preclinical laboratory use, this reagent serves as a critical tool for developing needle-free drug delivery systems, advanced transdermal patches, and high-bioavailability skincare actives that traditional chemical enhancers cannot achieve.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Antho-Rfamide
CAS NO.	888486-23-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C40H64N14O16S2
Molecular Weight	1061.21 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Soluble in water or dilute acetic acid; insoluble in common organic solvents
Endotoxin	≤0.5 EU/mg
Biological Activity	Acts as an RFamide-type neuropeptide; modulates ion channels and neurotransmitter release; binds to G-protein-coupled receptors (GPCRs); used to study neuromuscular transmission and primitive nervous system signaling
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1kit

1.MECHANISM OF ACTION

The biological activity of Transdermal Peptide is driven by its specific and reversible interaction with the Na+/K+-ATPase beta-subunit (ATP1B1) located on the cell membranes within the epidermal layer of the skin. Upon topical application, the peptide binds predominantly to the C-terminus of the ATP1B1 receptor, which subsequently modulates the localization and expression of this enzyme and alters the structural arrangement of intercellular lipids in the stratum corneum. This interaction creates transient, energy-dependent micro-channels or openings in the tight junction barriers of the skin without causing permanent damage, cytotoxicity, or significant inflammation, thereby allowing co-administered or fused large molecular weight therapeutic and cosmetic agents to passively diffuse or be actively transported into the systemic circulation or deeper dermal layers.

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2.PRODUCT INDICATIONS

This product is indicated for preclinical R&D applications targeting professionals in pharmaceutics, dermatology, and cosmetic chemistry who are investigating novel transdermal delivery vehicles, skin permeability assays, and localized therapeutic interventions. It is particularly suitable for researchers formulating topical gels, creams, or patches intended to deliver biologics like Insulin, hGH, EGF, Botulinum toxin, or nucleic acids (siRNA) to treat conditions such as diabetes, growth deficiencies, wound healing, and genetic skin disorders in animal models. Additionally, it is applicable for cosmetic scientists aiming to enhance the dermal penetration of anti-aging peptides and antioxidants to improve efficacy in skin elasticity, wrinkle reduction, and cellular repair studies conducted under controlled laboratory settings.

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3.CLINICAL EFFICACY OF PRODUCT

As a raw biochemical reference material not approved for human therapeutics, Transdermal Peptide itself does not hold clinical efficacy, yet it demonstrates profound delivery-enhancing efficacy in extensive in vitro and in vivo animal model studies. Preclinical data confirm that co-administration of this peptide with Insulin via topical application to diabetic rat models results in significant systemic absorption of the insulin and sustains blood glucose reduction for over 11 hours, effectively mimicking subcutaneous injection profiles. Furthermore, research validates its capability to facilitate the transdermal delivery of human Growth Hormone and siRNA into systemic circulation and epidermal cells respectively, achieving targeted gene knockdown and bioactive serum levels, which underscores its powerful utility as a formulation excipient in the development of future needle-free transdermal pharmaceutical and dermatological products.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags:Transdermal Delivery, Penetration Enhancer, TD-1, Skin Barrier, Pharmaceutical Excipient, Cosmetic Peptide, Drug Delivery System, ATP1B1, Needle-Free, Macromolecule Delivery, Dermatological Research, Biochemical Reagent.

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