Fmoc-Ser(tBu)- Ile-Aib-OH

Fmoc-Ser(tBu)-Ile-Aib-OH is a high-purity synthetic tripeptide building block specifically designed for advanced peptide synthesis applications. This protected peptide derivative features orthogonal protecting groups (Fmoc, tBu) and incorporates the non-natural amino acid Aib (2-aminoisobutyric acid), providing enhanced conformational control in peptide chain assembly. With excellent solubility in organic solvents and verified HPLC purity, it serves as a critical intermediate in solid-phase peptide synthesis for pharmaceutical research, drug discovery, and structural biology studies. Our product undergoes rigorous quality control to ensure batch-to-bartch consistency and reliable performance in demanding synthesis workflows.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Fmoc-Ser(tBu)-Ile-Aib-OH
CAS NO.	/
Appearance	white to off-white, fluffy or crystalline powder
Molecular Formula	C₃₀H₃₈N₃O₆
Molecular Weight	536.6 g/mol
Purity (RP-HPLC)	≥ 95%
Solubility	Soluble in DMF, DMSO, methanol, chloroform; partially soluble in acetonitrile.
Endotoxin	< 1.0 EU/mg (if for research/analytical grade)
Biological Activity	Protected tripeptide building block; used for solid-phase peptide synthesis (SPPS) to introduce a β-branched (Ile) and α,α-dialkylated (Aib) structure.
Storage Conditions	Store at 2-8°C, protected from light and moisture.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

As a protected peptide building block, Fmoc-Ser(tBu)-Ile-Aib-OH functions as a controlled synthetic intermediate rather than a biologically active compound. Its Fmoc protecting group enables selective deprotection under basic conditions during solid-phase peptide synthesis, while the Aib residue introduces conformational constraints that can stabilize secondary structures in the final peptide. This combination allows researchers to precisely construct peptides with enhanced metabolic stability, improved membrane permeability, and targeted biological activities through controlled sequential coupling reactions.

2.PRODUCT INDICATIONS

Peptide Drug Development: Intermediate for synthesizing constrained peptides and peptidomimetics with enhanced therapeutic properties

Structural Biology Research: Tool for studying the effects of Aib incorporation on peptide conformation and stability

Medicinal Chemistry: Building block for structure-activity relationship studies and lead optimization

Custom Peptide Synthesis: Key component in the production of specialized peptides for academic and industrial research

GPCR-targeted Peptides: Particularly valuable for designing stabilized analogs targeting G-protein coupled receptors

3.CLINICAL EFFICACY OF PRODUCT

Synthesis Performance: Demonstrated high coupling efficiency (>95%) and minimal epimerization in peptide assembly processes

Quality Consistency: Verified batch-to-bartch reproducibility through comprehensive analytical characterization

Research Utility: Proven effectiveness in generating peptides with enhanced in vivo stability and biological activity

Process Reliability: Successfully utilized in the synthesis of peptide candidates under preclinical investigation

Formulation Compatibility: Compatible with standard peptide synthesis protocols and purification methodologies

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.