Cariprazine CAS NO.839712-12-8
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Cariprazine (Free Base) |
| CAS NO. | 839712-12-8 |
| Appearance | Off-white to light beige solid powder |
| Molecular Formula | C₂₁H₃₂Cl₂N₄O |
| Molecular Weight | 427.41 g/mol |
| Purity (RP-HPLC) | ≥99.0% |
| Solubility | DMSO: 2–3 mg/mL (4.68–7.01 mM); Ethanol: 6 mg/mL; Water: Insoluble |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Dopamine D₂/D₃ receptor partial agonist; High affinity for D₃ (Kᵢ=0.085 nM) and D₂ (Kᵢ=0.49 nM) receptors; Moderate affinity for 5‑HT₁A receptor (Kᵢ=2.6 nM) |
| Storage Conditions | Powder: Store at -20°C, sealed, dry, protected from light; Avoid repeated freeze‑thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Cariprazine's unique mechanism involves partial agonism with high affinity at dopamine D3 and D2 receptors, and serotonin 5-HT1A receptors, while acting as an antagonist at 5-HT2B and 5-HT2A receptors. Its preferential D3 receptor activity is believed to contribute to its beneficial effects on negative symptoms and cognitive dysfunction in schizophrenia. The balanced modulation of dopaminergic and serotonergic systems enhances mood stability, reduces positive symptoms (e.g., hallucinations), and improves cognitive/negative symptoms with a favorable extrapyramidal side effect (EPS) profile.
2.PRODUCT INDICATIONS
- Pharmaceutical Analysis: Certified Reference Standard for assay, impurity profiling, and stability testing of Cariprazine APIs and finished dosage forms.
- Bioanalytical Research: Internal standard for LC-MS/MS method development in pharmacokinetic and toxicokinetic studies.
- Metabolite Studies: Investigation of its major active metabolites (DCAR, DDCAR).
- Comparative Studies: In vitro receptor binding and functional assays to study its unique pharmacological profile.
3.CLINICAL EFFICACY OF PRODUCT
Cariprazine's clinical efficacy is well-established in multiple large-scale, randomized, placebo-controlled trials. In schizophrenia, it significantly improves both positive and negative symptom scales (PANSS). In bipolar I disorder, it effectively reduces manic symptoms (YMRS). As an adjunct in MDD, it leads to significant improvement in depressive symptoms (MADRS). It demonstrates a favorable long-term tolerability profile with lower risks of weight gain, metabolic disturbances, and sedation compared to some other atypical antipsychotics, supporting its use for maintenance treatment.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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