Name: HIV-1 Tat Protein (49-57) for Enhanced Research Applications
Availability: InStock
Rating: 4.5 (89 reviews)

HIV-1 tat Protein (49-57) CAS NO.123251-89-8

HIV-1 tat Protein (49-57) is a synthetic, highly cationic nonapeptide corresponding to the polybasic region of the HIV-1 Trans-Activator of Transcription (Tat) protein, supplied as a white lyophilized powder strictly for non-clinical laboratory research. It serves as a premier Cell-Penetrating Peptide (CPP) and a vital research tool for scientists investigating intracellular delivery mechanisms, particularly as a gold-standard model for the Protein Transduction Domain (PTD). This product is specifically designed for use by pharmaceutical R&D specialists, bioconjugate chemists, and cell biologists who require a reliable vector to facilitate the transmembrane transport of macromolecular cargoes, such as proteins, nucleic acids, nanoparticles, and contrast agents, into living cells for drug delivery, gene therapy, and bioimaging applications.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	HIV-1 tat Protein (49-57)
CAS NO.	123251-89-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C53H106N30O11
Molecular Weight	1339.63 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Soluble in water or dilute acetic acid; insoluble in common organic solvents
Endotoxin	≤0.5 EU/mg
Biological Activity	Induces efficient cellular uptake of macromolecules; acts as a potent cell-penetrating peptide (CPP)
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1kit

1.MECHANISM OF ACTION

The primary biological mechanism of HIV-1 tat Protein (49-57) relies on its uniquely high positive charge density, derived from a sequence rich in arginine and lysine residues, which enables efficient translocation across the hydrophobic cell membrane lipid bilayer. Initially, the peptide engages in electrostatic interactions with anionic components on the cell surface, primarily heparan sulfate proteoglycans (HSPGs), which concentrate the peptide at the membrane interface. Following this adsorption, the peptide utilizes energy-dependent endocytic pathways, such as macropinocytosis, or potentially direct translocation mechanisms involving the formation of transient pores or inverted micelles, to traverse the plasma membrane. Once internalized, this cationic peptide can escape endosomal entrapment and release its conjugated bioactive cargo into the cytosol or facilitate nuclear localization, thereby bypassing the limitations of traditional membrane impermeability for large therapeutic molecules.

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2.PRODUCT INDICATIONS

This product is indicated for preclinical research applications targeting professionals in drug delivery, molecular biology, and biochemistry who are engineering novel therapeutics, vaccines, and diagnostic probes capable of crossing biological barriers. It is particularly suitable for researchers utilizing the peptide as a covalent linker or fusion tag to deliver biologically active cargos like siRNAs, plasmids, antibodies, enzymes, and imaging agents into difficult-to-transfect cell lines and primary cells without the need for physical disruption or viral vectors. Furthermore, it is applicable for cell penetration studies, investigating the structure-activity relationships of arginine-rich motifs, and serving as a positive control or standard reference in assays measuring cellular uptake efficiency, endocytosis inhibition, and the development of next-generation non-viral transfection reagents in controlled laboratory settings.

3.CLINICAL EFFICACY OF PRODUCT

As a raw biochemical research reagent not formulated for human therapeutic use, HIV-1 tat Protein (49-57) does not possess approved clinical efficacy, yet it demonstrates profound functional efficacy in extensive in vitro and in vivo preclinical studies as a delivery vehicle. Experimental data confirm that conjugating this peptide to various macromolecules—ranging from large proteins like β-galactosidase and antibodies to nucleic acids like DNA and siRNA—significantly enhances their cellular internalization rates and allows them to exert their biological functions intracellularly. Additionally, research validates its utility in animal models where systemic administration of Tat-fused proteins leads to tissue distribution and therapeutic effects, such as targeted tumor regression or gene silencing, underscoring its powerful role as a foundational tool in the design and optimization of clinically viable cell-penetrating peptide technologies rather than acting as a standalone drug.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags:Cell-Penetrating Peptide, CPP, Protein Transduction, Drug Delivery, Gene Therapy, RKKRRQRRR, Arginine-Rich Motif, Research Chemical, Bioconjugation, Intracellular Delivery, Transfection Agent, Biomolecule Carrier.

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