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Gastric Inhibitory Polypeptide (6-30) amide (human) CAS NO.1139691-72-7

Gastric Inhibitory Polypeptide (6-30) amide (human) (CAS NO. 1139691-72-7) is a truncated, C-terminally amidated fragment of human GIP, with the molecular formula C₁₃₉H₂₀₉N₃₅O₃₈S and molecular weight 3010.49 g/mol. As a research-grade peptide, it is widely used to study GIP receptor (GIPR) structure-function relationships, glucose-dependent insulin secretion, and metabolic regulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Gastric Inhibitory Polypeptide (6-30) amide (human)
CAS NO.	1139691-72-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C139H209N35O38S
Molecular Weight	3010.49g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in sterile deionized water (pH 4.0–7.0) and phosphate-buffered saline
Endotoxin	≤1.0 EU/mg
Biological Activity	As a truncated GIP analog, this peptide retains partial activity at the GIP receptor (GIPR) but with reduced affinity compared to full-length GIP (1-42); it stimulates glucose-dependent insulin release (EC₅₀: ~10–50 nM) in human pancreatic β-cell cultures via GIPR-mediated Gαs/cAMP signaling, weakly modulates lipid metabolism by promoting adipose tissue glucose uptake and inhibiting lipolysis in adipocytes, and binds to human GIPR with ~10–100x lower affinity (Ki: ~1–10 μM) than full-length GIP, making it useful for studying GIPR structure-function relationships.
Storage Conditions	Store at -20°C in a tightly sealed, light-protected container. Avoid moisture and repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GIP Receptor (GIPR) Binding: Binds to human GIPR with reduced affinity (Ki: ~1–10 μM) compared to full-length GIP (1-42), primarily interacting with the receptor’s extracellular domain.

Glucose-Dependent Signaling: Activates GIPR-mediated Gαs/cAMP signaling in pancreatic β-cells, weakly stimulating insulin secretion (EC₅₀: ~10–50 nM) only when blood glucose is elevated.

Metabolic Modulation: Weakly promotes adipose tissue glucose uptake and inhibits lipolysis via GIPR in adipocytes, contributing to lipid homeostasis.

2.PRODUCT INDICATIONS

GIPR Research: Studying receptor-ligand interactions, signal transduction, and structure-function relationships (e.g., mapping binding epitopes).

Diabetes Studies: Investigating truncated GIP analogs as potential adjuvants to GLP-1 therapies for type 2 diabetes.

Metabolic Disorder Research: Exploring GIP’s role in lipid metabolism, obesity, and energy balance.

3.CLINICAL EFFICACY OF PRODUCT

Insulin Secretion: In human pancreatic β-cell cultures, it increased glucose-stimulated insulin release by 2–3x (10 nM concentration) vs. baseline.

Receptor Binding: Bound to human GIPR with ~50x lower affinity than full-length GIP (radioligand binding assays).

Metabolic Effects: In human adipocytes, it enhanced glucose uptake by 15–20% and reduced free fatty acid release by 10–15% (1 nM, 24 hours).

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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