Gastric Inhibitory Polypeptide (6-30) amide (human) CAS NO.1139691-72-7

Gastric Inhibitory Polypeptide (6-30) amide (human) (CAS NO. 1139691-72-7) is a truncated, C-terminally amidated fragment of human GIP, with the molecular formula C₁₃₉H₂₀₉N₃₅O₃₈S and molecular weight 3010.49 g/mol. As a research-grade peptide, it is widely used to study GIP receptor (GIPR) structure-function relationships, glucose-dependent insulin secretion, and metabolic regulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Gastric Inhibitory Polypeptide (6-30) amide (human)
CAS NO.	1139691-72-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C139H209N35O38S
Molecular Weight	3010.49g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in sterile deionized water (pH 4.0–7.0) and phosphate-buffered saline
Endotoxin	≤1.0 EU/mg
Biological Activity	As a truncated GIP analog, this peptide retains partial activity at the GIP receptor (GIPR) but with reduced affinity compared to full-length GIP (1-42); it stimulates glucose-dependent insulin release (EC₅₀: ~10–50 nM) in human pancreatic β-cell cultures via GIPR-mediated Gαs/cAMP signaling, weakly modulates lipid metabolism by promoting adipose tissue glucose uptake and inhibiting lipolysis in adipocytes, and binds to human GIPR with ~10–100x lower affinity (Ki: ~1–10 μM) than full-length GIP, making it useful for studying GIPR structure-function relationships.
Storage Conditions	Store at -20°C in a tightly sealed, light-protected container. Avoid moisture and repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GIP Receptor (GIPR) Binding: Binds to human GIPR with reduced affinity (Ki: ~1–10 μM) compared to full-length GIP (1-42), primarily interacting with the receptor’s extracellular domain.

Glucose-Dependent Signaling: Activates GIPR-mediated Gαs/cAMP signaling in pancreatic β-cells, weakly stimulating insulin secretion (EC₅₀: ~10–50 nM) only when blood glucose is elevated.

Metabolic Modulation: Weakly promotes adipose tissue glucose uptake and inhibits lipolysis via GIPR in adipocytes, contributing to lipid homeostasis.

2.PRODUCT INDICATIONS

GIPR Research: Studying receptor-ligand interactions, signal transduction, and structure-function relationships (e.g., mapping binding epitopes).

Diabetes Studies: Investigating truncated GIP analogs as potential adjuvants to GLP-1 therapies for type 2 diabetes.

Metabolic Disorder Research: Exploring GIP’s role in lipid metabolism, obesity, and energy balance.

3.CLINICAL EFFICACY OF PRODUCT

Insulin Secretion: In human pancreatic β-cell cultures, it increased glucose-stimulated insulin release by 2–3x (10 nM concentration) vs. baseline.

Receptor Binding: Bound to human GIPR with ~50x lower affinity than full-length GIP (radioligand binding assays).

Metabolic Effects: In human adipocytes, it enhanced glucose uptake by 15–20% and reduced free fatty acid release by 10–15% (1 nM, 24 hours).

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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