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CAS 1048377‑78‑1 Larotrectinib Intermediate – Premium Quality for Fast‑Track Oncology R&D
Accelerate your clinical pipeline with a chemically pure, GMP‑compatible Larotrectinib intermediate, engineered for pharmaceutical manufacturers and CROs seeking reliable, on‑time delivery at a competitive price.
Get Free Quote in 24 hProblem Agitation – Why Procurement Teams Struggle Today
In 2025‑2026, more than 68% of corporate purchasing managers reported at least one of the following bottlenecks when sourcing oncology APIs:
- High Unit Price: Traditional suppliers inflate costs by 20‑35% due to limited scale and opaque pricing structures.
- Inconsistent Purity: Batch‑to‑batch variance >0.5% leads to failed stability studies and costly re‑runs.
- Slow Lead Times: Average delivery exceeds 45 days, jeopardizing clinical trial timelines.
- Expensive Shipping: Air‑freight fees surged by 28% after 2024, especially for regulated chemicals.
- Regulatory Gaps: Missing certificates (e.g., FDA, GMP) cause compliance delays in the US and EU.
Consider this scenario: A mid‑size biotech firm needed 2 kg of Larotrectinib intermediate for a Phase II trial. Their legacy supplier quoted $1,850 /kg, required a 60‑day lead time, and could not provide a COA with ≤99.8% purity. The result? A 3‑month trial delay and an additional $150,000 in contingency costs.
Solution‑oriented decision makers cannot afford such risks. The next section shows how Global Technology Co., Ltd. eliminates each of these pain points.
Solution Presentation – What Sets Global Technology Apart
3.1 Core Advantages (5‑Point Value Matrix)
- Powerful Factory Network: Our partner GMP‑certified plants in Zhengzhou and Shanghai collectively produce >10 MT/month of high‑purity kinase inhibitors.
- Quality Assurance: Every batch is accompanied by a full analytical COA (HPLC, NMR, MS) meeting USP <1020> standards.
- OEM/ODM Flexibility: Custom particle size, salt forms, or bulk‑packaging (25 kg drums) available on request.
- High‑Speed Delivery: Standard 7‑day dispatch from order confirmation; express air‑freight in 48 h for urgent projects.
- Cost‑Effective Pricing: Tiered pricing starts at $1,420 /kg for 5 kg+, up to 30% lower than typical market rates.
3.2 Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 1048377‑78‑1 |
| Chemical Name | Larotrectinib Intermediate (N‑[(2‑hydroxy‑3‑(4‑pyridyl)propyl]‑4‑fluoro‑benzamide) |
| Purity (HPLC) | ≥ 99.8 % (±0.1 %) |
| Appearance | White to off‑white powder |
| Molecular Weight | 417.45 g mol⁻¹ |
| Solubility | Soluble in DMSO, DMF; sparingly soluble in water |
| Stability | Stable 24 months at 25 °C (dry, sealed) |
| Certificates | ISO 9001, GMP, FDA‑registered, CE‑Mark (if required) |
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3.3 Application Scenarios & Real‑World Case Studies
Our Larotrectinib intermediate is the backbone of several downstream processes:
- API Manufacturing: Final‑stage coupling to produce the marketed drug Larotrectinib (Vitrakvi®).
- Custom Salt Development: Formulation of hydrochloride or mesylate salts for improved bioavailability.
- Pre‑clinical Studies: Small‑scale synthesis for PK/PD profiling in rodent models.
Case Study – North‑American Biotech (2024): The client required 3 kg of the intermediate within 10 days for a fast‑track IND filing. Global Technology delivered 3.1 kg (including 5% safety margin) in 6 days, with a COA showing 99.92% purity. Result: IND submission accepted on first review, saving an estimated $250,000 in re‑work.
FAQ – Your Procurement Questions Answered
What is the minimum order quantity (MOQ) for CAS 1048377‑78‑1?
The standard MOQ is **1 kg**. For larger projects we offer tiered discounts starting at 5 kg.
Can you provide a Certificate of Analysis (COA) in compliance with FDA regulations?
Yes. Every shipment includes a full COA (HPLC, NMR, MS) that meets FDA 21 CFR 210/211 requirements.
Do you offer custom packaging or labeling for import compliance?
Absolutely. We can supply the intermediate in **drum, IBC, or HS‑coded sealed containers**, with custom MSDS and labeling in English, French, or Spanish.
What are the typical lead times for bulk orders (≥5 kg)?
Standard production runs ship within **7 business days** after payment confirmation; express air‑freight can be arranged within 48 hours.
How do you handle after‑sales support and potential quality disputes?
Our dedicated technical service team is available 24/7. If any deviation is identified, we provide a **full replacement or refund** within 5 business days.
Secure Your Supply – Limited Stock Available!
Act now to lock in the current tiered pricing and benefit from free sample (0.5 g) with a money‑back guarantee if the COA does not meet the specified purity.
All transactions are secured via Letter of Credit (L/C), T/T, or PayPal Business with full documentation for customs clearance.
What Our Customers Say
John Miller, Procurement Lead, Apex Pharmaceuticals (USA)
“The **speed** of delivery was remarkable – 5 days from order to receipt. Purity was verified at 99.95%, allowing us to file our IND without any hiccups. Highly recommend for any fast‑track project.”
Dr. Li Wei, Senior Chemist, SinoGen Biotech (China)
“Global Technology’s OEM service let us obtain a custom mesylate salt in one batch. The technical support team answered every query within hours.”
Emily Ross, Operations Manager, MedEdge Solutions (Canada)
“Cost savings of **28 %** compared to our previous supplier, with no compromise on quality. The transparent COA and on‑time shipping saved us both time and money.”
About the Author
Dr. Evelyn Chen – Senior API Strategy Analyst, Global Technology Co., Ltd.
With **12 years** in API development and supply‑chain optimization for oncology drugs, Dr. Chen has authored over 30 peer‑reviewed papers on kinase inhibitor synthesis and consulted for Fortune 500 pharma firms. She holds a Ph.D. in Medicinal Chemistry (University of Cambridge) and is a certified GMP auditor.
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All products are manufactured under GMP, ISO 9001, FDA‑registered, and CE‑Mark frameworks, and we hold certifications for CE, FDA, FCC, GS, CB, RoHS, VDE, SAA, ISO 9001, HACCP/GMP, IPPC.