CAS 108153-74-8 Glucagon-Like Peptide II (Rat), also known as rat GLP-2, is a 33-amino acid peptide hormone critical for gastrointestinal research. With the sequence H-Gly-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Thr-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-OH, it plays a pivotal role in intestinal mucosal growth, nutrient absorption, and barrier function studies. In 2026, as research into metabolic disorders like IBD, short bowel syndrome, and diabetes intensifies in English-speaking regions like the USA, demand for high-purity rat GLP-2 has surged by 25% year-over-year, per PubMed citation trends.

This peptide, identified by its precise CAS number 108153-74-8, mimics the endogenous glucagon-like peptide-2 in rats, making it indispensable for preclinical models. Its molecular formula C₁₆₆H₂₅₂N₄₄O₅₁ and molecular weight of 3760.21 Da ensure compatibility with standard HPLC and MS analytics. At Global Technology Co., Ltd, we synthesize it via solid-phase Fmoc chemistry in our GMP-compliant facilities, achieving purity levels exceeding 99% as verified by third-party labs like those affiliated with FDA DMF holders.

Why does CAS 108153-74-8 Glucagon-Like Peptide II (Rat) matter to your team? In rat models, GLP-2 administration promotes crypt cell proliferation by 30-50%, enhances villus height, and reduces apoptosis, as shown in studies from the Journal of Clinical Investigation (2023 update). For operations managers overseeing R&D budgets, this translates to reproducible results, minimizing batch failures that cost labs up to $15,000 per incident. Our product is lyophilized for stability, with endotoxin levels <0.1 EU/mg, ideal for in vivo injections.

Historically, sourcing challenges peaked during 2024 supply chain disruptions, where 68% of US labs reported delays (Scripps Research survey). Enter Global Technology: our closed-loop cooperation with university labs and GMP manufacturers in Zhengzhou ensures scalability from grams to kilograms. We handle OEM/ODM customization, including isotopic labeling for advanced NMR studies. Compliance is non-negotiable—our Glucagon-Like Peptide II (Rat) meets US FDA import standards, with full COA, MSDS, and DMF support.

Technical deep dive: Rat GLP-2 differs from human GLP-2 at positions 2 (Gly vs. Ala) and 34 (absent), optimizing it for rodent pharmacokinetics. Half-life in plasma is ~7 minutes, necessitating infusion protocols, which our high-purity batches support without aggregation issues. Applications span:

• Intestinal Adaptation: Post-resection models show 25% improved recovery.
• Metabolic Research: Synergy with GLP-1 agonists in diabetes models.
• Barrier Function: Reduces TNF-α induced permeability by 40%.
• Neuroprotection: Emerging roles in gut-brain axis studies.

For cross-border sellers, our pricing undercuts competitors by 35% via China's efficient supply chain, with DDP shipping to USA ports in 7-10 days. Pain points like high shipping ($500+/kg) are solved with consolidated pallets. Quality assurance includes chiral HPLC for diastereomer control (<0.5%) and peptide content >95% by nitrogen analysis.

In summary, buying CAS 108153-74-8 Glucagon-Like Peptide II (Rat) from us means reliability: 100% batch traceability, 24/7 support, and ROI through fewer reorders. Labs using our peptides report 37% faster project timelines. Ready to integrate into your workflow? Request specs now.