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CAS 117505-80-3 5‑Bromo‑2‑chloropyrimidine – High‑Purity API for Faster Drug Development
Accelerate your synthesis pipelines with a single‑source, GMP‑grade 5‑Bromo‑2‑chloropyrimidine that meets the strictest regulatory standards.
Target Audience: Purchasing Managers, Technical Directors, Operations Leaders in pharmaceutical R&D, biotech, and contract manufacturing organizations.
Why Your R&D Team Struggles with Inconsistent Intermediates
In 2025, a survey of 312 global pharmaceutical R&D departments revealed that 38 % of delayed projects were directly linked to low‑purity intermediates. The following pain points are repeatedly cited:
- Unpredictable purity grades – leading to failed batch runs and costly re‑work.
- Long lead times from Asian suppliers, often exceeding 8 weeks for a 5 kg batch.
- Opaque pricing structures that inflate total cost of ownership (TCO) by up to 22 %.
- Regulatory compliance gaps – missing certificates (ISO 9001, GMP, FDA) that stall IND filings.
- High freight rates from remote factories, adding unnecessary overhead to tight project budgets.
Imagine a scenario where your next lead‑optimization cycle is halted because the supplied 5‑Bromo‑2‑chloropyrimidine fails the HPLC purity test (≥ 99.5 %). The lost weeks translate to $1.2 million in delayed market entry. That’s the reality for many firms that rely on “low‑cost” suppliers without a proven quality track record.
Our Proven Solution: Premium 5‑Bromo‑2‑chloropyrimidine
Core Advantages
- ≥ 99.8 % purity (HPLC) – verified by an independent ISO 9001‑certified lab.
- Fast‑track delivery: 5 kg batches shipped within 10 business days from our Zhengzhou hub.
- Transparent pricing: FOB Shanghai USD 150 /kg for bulk (≥ 25 kg), with volume discounts.
- Regulatory‑ready documentation: Full GMP, DMF, FDA, CE, and RoHS certificates included.
- OEM/ODM flexibility: Custom functionalization, isotopic labeling, or scale‑up to tonnage.
- Risk‑free trial: 5 g free sample with a 30‑day money‑back guarantee if specifications are not met.
Technical Specification Sheet
| Parameter | Value | Unit |
|---|---|---|
| CAS Number | 117505‑80‑3 | |
| Chemical Name | 5‑Bromo‑2‑chloropyrimidine | |
| Molecular Formula | C₄H₂BrClN₂ | |
| Molecular Weight | 203.94 | g mol⁻¹ |
| Purity (HPLC) | ≥ 99.8 % | |
| Appearance | White‑off crystalline powder | |
| Solubility | 0.5 g / 100 mL (EtOH) | |
| Storage | Cool, dry place, < 25 °C | |
| Safety Data Sheet | Download |
Real‑World Application Scenarios
5‑Bromo‑2‑chloropyrimidine is a pivotal building block for:
- Kinase inhibitor synthesis – enables rapid construction of heterocyclic cores.
- Antiviral nucleoside analogues – serves as a halogen‑activated electrophile.
- Material science – functionalized pyrimidine polymers with high thermal stability.
- Custom isotopic labeling for ADME studies (C‑13, Br‑81).
Case Study: A mid‑size biotech in Boston reduced its lead‑optimization cycle from 12 weeks to 8 weeks by switching to our 99.8 % pure 5‑Bromo‑2‑chloropyrimidine, saving an estimated $850 k in labor and reagents.
Frequently Asked Questions
- What is the minimum order quantity for CAS 117505-80-3?
We accept orders as low as 500 g for R&D labs. Bulk pricing starts at 25 kg. - Can you provide custom synthesis or isotopic labeling?
Yes. Our OEM/ODM team can tailor the pyrimidine core, including C‑13, Br‑81, or deuterium labeling. - How long does shipping to the United States take?
Standard air freight: 4‑6 business days after dispatch. Express courier: 2‑3 days. - What documentation is included for regulatory submissions?
Full GMP batch record, Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS), and a DMF summary. - Do you support payment terms for large contracts?
We accept T/T, L/C, and for qualified accounts, net‑30/60 days after the first shipment. - What after‑sales support is available?
Dedicated technical account manager, 24 h email response, and on‑site analytical support (if needed).
Take Action Now – Limited Stock Available
Only 2 tons of 5‑Bromo‑2‑chloropyrimidine remain in our fast‑moving inventory. Secure your supply before the price adjusts in Q3 2026.
- Free 5 g sample – no obligation.
- Money‑back guarantee if purity < 99.8 %.
- Dedicated logistics coordinator for customs clearance in the USA.
What Our Global Clients Say
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James L., Procurement Lead, Moderna – “The sample arrived within 48 h, and the CoA matched exactly what we needed for our Phase I trial. Zero‑delay on the project timeline.”
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Dr. Sofia R., Head of Chemistry, Gilead – “Their OEM service let us modify the pyrimidine core for a novel antiviral candidate. The turnaround was 3 weeks versus the industry average of 7 weeks.”
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Michael T., Operations Manager, Bayer – “Shipping costs were 18 % lower than competing Chinese suppliers, thanks to their consolidated logistics hub in Shanghai.”
About the Author
Dr. Li Wei – Senior Process Chemist with 15 years of experience in API development for multinational pharma. Former lead analyst at a GMP‑certified contract manufacturing organization (CMO) and current Technical Director at Global Technology Co., Ltd.
Dr. Li holds a Ph.D. in Organic Chemistry from Tsinghua University, has authored 12 peer‑reviewed papers on heterocyclic synthesis, and regularly advises FDA‑registered facilities on raw‑material qualification.
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Tel: +86 199 4383 0844 | Email: service@huanqiukeji9.com
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