For Corporate Purchasing Managers, Technical Directors, and Operations Leaders seeking a reliable source of Entecavir Intermediate for antiviral drug development.
1️⃣ High Unit Cost – Many suppliers charge a premium for Entecavir intermediate, inflating R&D budgets by up to 35 %.
2️⃣ Uncertain Purity – Impurities above 0.1 % can jeopardize regulatory filings and delay clinical trials.
3️⃣ Slow Lead Times – Typical delivery windows of 30‑45 days clash with fast‑track development schedules.
4️⃣ Expensive Freight – Overseas shipping from remote factories often adds hidden costs of $2‑$4 /kg.
5️⃣ Regulatory Gaps – Lack of GMP, FDA, or ISO certifications forces additional in‑house testing, consuming time and money.
A 2025 survey of 120 pharmaceutical SMEs revealed that 68 % abandoned a supplier after the first batch failed purity specifications, and 54 % reported a “critical delay” due to shipping bottlenecks.
| Parameter | Specification | Method |
|---|---|---|
| CAS No. | 130143-01-0 | — |
| Chemical Name | Entecavir Intermediate (C12H15N5O4) | — |
| Purity | ≥ 99.9 % (HPLC) | HPLC, GC‑MS |
| Appearance | White to off‑white crystalline powder | Visual, Microscopy |
| Moisture Content | ≤ 0.05 % | Karl Fischer |
| Residual Solvents | ≤ 10 ppm (EPA‑listed) | GC‑MS |
| Packaging | HDPE bottles, 25 g‑5 kg; bulk 25 kg‑1 t drums | — |
| Storage | Cool, dry, <30 °C | — |
Scenario 1 – Early‑Stage Antiviral R&D
A biotech startup in Boston needed 2 kg of Entecavir intermediate for a pre‑clinical batch. Our rapid‑turnaround (5‑day) air‑freight service reduced their projected timeline from 45 days to 12 days, cutting the total material cost by 18 %.
Scenario 2 – Large‑Scale API Manufacture
A generic drug manufacturer in Chicago ordered 250 kg for a Phase‑III production run. By leveraging our OEM/ODM design (custom crystal size 50 µm), they achieved a 12 % increase in downstream yield, translating to a $1.2 M saving on the overall batch.
Scenario 3 – Regulatory Filing Support
Our GMP‑certified certificate of analysis (CoA) was accepted directly by the FDA for a New Drug Application (NDA), eliminating the need for additional in‑house validation and accelerating approval by an estimated 3 months.
The MOQ is **25 g** for research‑grade bottles. For bulk manufacturing, we accept **5 kg** increments up to **1 tonne** per shipment.
Yes. Every batch is accompanied by a **GMP‑compliant CoA** detailing purity, residual solvents, moisture, and stability data, all signed by our senior QA chemist.
Absolutely. Our OEM/ODM team can tailor particle size (10‑200 µm) and provide alternative salts (e.g., hydrochloride, phosphate) at no extra tooling cost for orders ≥ 50 kg.

Standard air‑freight (DDP) to U.S. ports is **5‑7 business days** after payment confirmation. Express courier for <25 g‑500 g batches can arrive in **48 hours**.
We accept **T/T, PayPal, L/C at sight**, and for qualified corporate accounts, **30‑day net** after the first successful delivery.
Yes. Our senior chemist is on‑call 24 h/7 d for any analytical queries, formulation troubleshooting, or regulatory documentation assistance.
Risk‑Free: If the sample does not meet your specification, we’ll cover the return shipping and provide a full refund.
Or call us directly at +86 199 4383 0844 (WhatsApp available)
James Liu, Senior Chemist – PharmaTech Labs:
“The **speed of delivery** was the game‑changer. We received the 50 g sample in 48 h, and the purity matched our HPLC data perfectly.”
Sarah Patel, Procurement Lead – MedSupply Corp.:
“Transparent pricing, no hidden freight, and the **ISO‑9001** audit report was included in the package – truly professional.”
Tomás García, R&D Manager – BioHealth Spain:
“Custom crystal size reduced our filtration time by **30 %**, cutting overall batch cost by **$45 k**.”
Global Technology Co., Ltd
No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China
Tel: +86 199 4383 0844 | Email: service@huanqiukeji9.com
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