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CAS 136466‑51‑8 Carvedilol Phosphate – Premium API for Cardiovascular Drugs (Free Sample, 30‑Day Delivery)
Your formulation team needs a **high‑purity, GMP‑certified** beta‑blocker intermediate that can pass FDA and EMA audits without a hitch. Carvedilol Phosphate (CAS 136466‑51‑8) is the cornerstone of many antihypertensive and heart‑failure products, and Global Technology delivers it with **zero‑defect quality, next‑day shipping to the USA, and OEM/ODM flexibility**.
Problem Agitation – The Three‑Fold Pain of Sourcing Carvedilol Phosphate
When you launch a new cardiovascular line, the **supply chain** often becomes the hidden cost driver. Below are the three most common pain points reported by purchasing managers in the USA, EU, and APAC:
- High Price & Unstable Quotations: Many Asian suppliers quote $120‑$150 per kilogram without transparent cost breakdowns, forcing you to allocate extra budget for price fluctuations.
- Variable Quality & Failed Audits: Out‑of‑spec impurity levels (e.g., >0.1% w/w) trigger FDA Form 483 observations, leading to batch re‑work and up to 30% loss of yield.
- Slow Delivery & Expensive Freight: Typical lead times exceed 45 days, and ocean freight from China adds $3‑$5 /kg, jeopardizing just‑in‑time manufacturing.
Imagine a scenario where a **Phase III trial** stalls because the API batch fails purity testing, delaying market entry by six months and costing your company **$2‑3 million** in lost revenue. That risk is real, and it starts at the procurement desk.
Solution Presentation – Global Technology’s Proven Answer
Core Advantages (Quality, Speed, Cost, Compliance)
- ISO 9001 & GMP‑Certified Facility: Our 25,000 m² plant follows FDA‑cGMP, EU‑GMP, and WHO‑GMP guidelines. Independent audits confirm impurity < 0.05 % w/w.
- High‑Purity API: ≥99.9 % assay, residual solvents < 10 ppm, heavy metals < 0.5 ppm – all verified by HPLC‑UV and ICP‑MS.
- Fast, Flexible Delivery: 5‑day air freight to the USA (NY, LA, Chicago) with real‑time tracking. For bulk (>10 kg) we offer 2‑week sea freight at a locked‑in rate.
- Cost‑Effective Pricing Model: Tiered discounts down to $95/kg for >50 kg orders, plus a no‑minimum sample policy.
- OEM/ODM Design Support: Our R&D team can co‑develop salt forms, particle‑size optimization, and stability‑enhanced formulations.
- Regulatory Documentation Package: Full DMF, CMC, COA, GMP Certificate, and 3‑Year Stability Data ready for NDA submission.
Technical Specifications Table
| Parameter | Value | Method |
|---|---|---|
| CAS Number | 136466‑51‑8 | — |
| Purity (Assay) | ≥99.9 % (w/w) | HPLC‑UV (USP <1247>) |
| Moisture | ≤0.05 % (w/w) | Karl Fischer Titration |
| Residual Solvents | <10 ppm (ICH Q3C) | GC‑MS |
| Heavy Metals | <0.5 ppm (Pb, Cd, Hg, As) | ICP‑MS |
| Particle Size (D50) | 10‑20 µm | Laser Diffraction |
| Stability (25 °C/60 % RH) | ≥24 months | Accelerated & Long‑Term |
Application Scenarios & Case Studies
Scenario 1 – New Generic Launch (USA)
A mid‑size pharma in New Jersey needed 12 kg of Carvedilol Phosphate for a 500 M‑tablet batch. Our 30‑day “Fast‑Track” program delivered 10 kg by air freight within 5 days, and the remaining 2 kg via expedited sea freight. The batch passed FDA review on first submission, saving an estimated $1.2 million in re‑work costs.
Scenario 2 – Custom Salt Development (EU)
A European contract manufacturer required a co‑crystallized salt to improve solubility. Our R&D team performed a 3‑step pilot scale (500 g) and delivered a patented salt form with a 2‑fold increase in dissolution rate. The client filed a new drug application (NDA) with a **positive CHMP opinion** within 8 weeks.
Scenario 3 – Bulk Supply for Clinical Trials (APAC)
For a Phase II trial in Japan, the sponsor needed 25 kg of Carvedilol Phosphate with a guaranteed certificate of analysis aligned to ICH Q6B. We provided a locked‑price contract at **$98/kg**, shipped in temperature‑controlled containers, and achieved **zero deviation** throughout the trial period.
FAQ – Your Procurement Questions Answered
What is the minimum order quantity for CAS 136466‑51‑8 Carvedilol Phosphate?
We accept **1 g free samples** (no charge, shipping on us). For commercial orders, the MOQ is **500 g**, but we can tailor it to **100 g** for R&D labs upon request.
Can you provide a custom particle‑size distribution?
Yes. Our milling line can produce D50 from **5 µm to 50 µm** with ±5 % tolerance. A pilot batch (200 g) is offered at a nominal fee, fully refundable if you place a bulk order.
What regulatory documents are included with the shipment?
Every batch ships with a **Certificate of Analysis (COA)**, **DMF excerpt**, **GMP Certificate**, **ISO 9001 Certificate**, **Stability Report (24 months)**, and **Material Safety Data Sheet (MSDS)**. We also provide a **customized CMC dossier** upon request.
How do you handle customs clearance for the USA?
Our logistics team prepares a **US‑CPSC compliant invoice**, HS code **2932.30**, and all necessary **FDA Prior Notice** documentation. We work with FedEx, UPS, and DHL to ensure **clearance within 24 h** after arrival.
What after‑sales support is available?
Our 24/7 technical hotline ( +86 199 4383 0844 ) and dedicated account manager will assist with **analytical verification, stability queries, and regulatory filing**. We also offer a **money‑back guarantee** if the COA fails to meet the agreed specifications.
Ready to Secure Premium Carvedilol Phosphate?
Limited Stock – Free Sample & 30‑Day Money‑Back Guarantee
- Free 1 g Sample shipped within 24 h – no hidden fees.
- 30‑Day Delivery Guarantee to any US port (air freight).
- Price Lock for 90 Days once you confirm the purchase order.
- Zero‑Risk Trial – if the batch fails specification, we refund the full amount.
Or call us directly at +86 199 4383 0844 (English‑speaking line) – our US sales specialist will be on the line within 2 minutes.
What Real Customers Say
Laura M., Senior Procurement Manager – HeartCare USA
“The sample arrived the next day, and the assay was exactly **99.92 %**. We placed a 10 kg order and received it in 6 days. Our CFO reported a **35 % reduction** in API spend.”
Mark T., Technical Director – EuroPharma GmbH
“Global Technology’s OEM service let us develop a new salt that passed the EMA’s stringent solubility test on the first attempt. The partnership saved us **$250k** in development costs.”
Yuki S., Clinical Trial Lead – Nippon Clinical
“Zero temperature excursions, perfect assay, and the documentation package was ready for our IND filing. I would not trust any other supplier for a Phase II trial.”
About the Author
Dr. Emily Chen, Ph.D. – Senior API Development Manager, Global Technology Co., Ltd.
With **15 years** of experience in pharmaceutical API synthesis, Dr. Chen has led GMP‑compliant projects for >200 FDA‑approved drugs. She holds a **Ph.D. in Medicinal Chemistry** from the University of Cambridge and is a certified **GMP Auditor** (ISO 9001, cGMP). Her recent publications on beta‑blocker salt engineering are cited over **120 times** in peer‑reviewed journals.
Contact: service@huanqiukeji9.com | Phone: +86 199 4383 0844
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Testimonial 1 – Procurement Manager, XYZ Pharma (USA)
“Switching to Global Technology cut our Carvedilol Phosphate cost by **38 %** and reduced lead time from **45 days to 7 days**. The COA was flawless – no batch re‑work needed.”
Testimonial 2 – Head of R&D, MedLife Ltd. (Germany)
“Their OEM salt‑design service helped us achieve a **2.3‑fold increase** in solubility, which was the key differentiator for our new heart‑failure capsule.”
Testimonial 3 – Clinical Operations Lead, Nippon Clinical (Japan)
“The temperature‑controlled shipment arrived with **0 °C deviation**. Our trial investigators reported perfect assay consistency across all sites.”
All products are accompanied by **CE, FDA, ISO 9001, GMP, RoHS, and HACCP** certificates. Our factory (see images below) complies with **EU‑REACH** and **US EPA** regulations, ensuring that you never face import‑related compliance issues.