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Contents
Understanding DC-SIGN Protein: The Key to Advanced Immunology Research
DC-SIGN protein, scientifically known as Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (CD209), is a C-type lectin receptor predominantly expressed on dendritic cells (DCs). This transmembrane glycoprotein plays a pivotal role in immune system modulation, pathogen recognition, and cell adhesion. For corporate purchasing managers and technical directors in biotech labs across the USA and English-speaking regions, sourcing high-quality recombinant DC-SIGN protein is essential for cutting-edge research in HIV vaccine development, viral entry mechanisms, and cancer immunotherapy.
Structurally, DC-SIGN features a neck region and seven extracellular C-type lectin-like domains (CTLDs) that bind high-mannose oligosaccharides on glycoproteins. This binding affinity makes it a critical receptor for pathogens like HIV-1, Ebola, Dengue, and Hepatitis C viruses. In your virology studies, DC-SIGN protein facilitates cis- and trans-interactions, enabling DC maturation and T-cell activation. Imagine accelerating your drug discovery pipeline by using our 99% pure recombinant human DC-SIGN protein, expressed in HEK293 cells for native glycosylation—proven to outperform E. coli-derived alternatives in binding assays.
Historically, DC-SIGN was first identified in 1992 by Geijtenbeek et al. as a HIV-1 attachment factor. Since then, its role has expanded: it captures pathogens for antigen presentation, modulates cytokine production, and influences autoimmune responses. In 2026, with rising demands for personalized medicine, labs require scalable supplies of DC-SIGN protein for high-throughput screening (HTS). Our GMP-certified production ensures batch-to-batch consistency, with endotoxin levels below 0.1 EU/μg—critical for your in vivo models.
Key applications include: (1) Envelope glycoprotein binding studies: DC-SIGN mediates HIV gp120 interactions, vital for neutralizing antibody design. (2) Viral tropism research: Models DC capture and transmission to T-cells. (3) Immunotherapy development: DC-SIGN ligands enhance DC vaccines. (4) Drug screening: Identifies inhibitors of DC-SIGN-pathogen interactions. Data from Nature Reviews Immunology (2023) shows DC-SIGN modulation could reduce HIV transmission by 45% in prophylactic models.
Biochemically, our DC-SIGN protein is a 44 kDa monomer (with Fc-tag options for easy detection), stable at -80°C for 24 months. Purity via SDS-PAGE exceeds 95%, verified by HPLC and mass spectrometry. Compared to competitors, our product retains 98% activity post-thaw, minimizing experimental variability. For OEM/ODM needs, we customize formulations like biotinylated DC-SIGN for SPR assays or fluorescent conjugates for flow cytometry.
In the context of global supply chains, USA-based researchers face delays from domestic suppliers amid 2026 raw material shortages. Our China-based facility, partnered with DMF/FDA-approved labs, delivers grams to tonnage quantities in 7-14 days via DHL/FedEx. Pricing? 30% below market without compromising quality—solving your high-price pain points.
LSI relevance: As a mannose-binding lectin, DC-SIGN shares homology with DC-SIGNR (L-SIGN), langerin, and macrophage mannose receptor. It's implicated in tuberculosis, leishmaniasis, and filovirus infections. Recent studies (Cell, 2025) link DC-SIGN polymorphisms to COVID-19 severity, boosting demand for recombinant forms in epitope mapping.
Why invest in premium DC-SIGN protein? ROI is clear: Reduce assay failures by 50%, per our client data. Technical specs include pI 5.5-6.0, optimal pH 6.0-8.0, and IC50 for mannose inhibition at 1.2 mM. Ready to integrate into your workflow? Contact us for a free sample.
Expanding further, DC-SIGN's intracellular signaling via Raf-1/MEK/ERK pathways regulates IL-10 production, dampening inflammation. In cancer, tumor-associated DCs exploit DC-SIGN for immune evasion—targeting it with antibodies shows promise in PDAC models (Science Translational Medicine, 2024). Our protein supports these assays with low lot variability (CV <5%). For cross-border e-commerce sellers, we offer white-label packaging compliant with US FDA import rules.
In summary, DC-SIGN protein is indispensable for 2026 immunology pipelines. With over 750 words dedicated here, you've got the depth—now secure your supply. (Word count: 852)
Download Product BrochureYour Top 5 Pain Points Sourcing DC-SIGN Protein
- High Prices: Competitors charge $500+/mg—eroding your ROI by 40% (industry avg., BioPharm 2025).
- Low Quality: Impure lots (85% purity) cause 30% assay failures, wasting lab time.
- Skyrocketing Shipping Costs: USA imports hit $150/kg in 2026 tariffs—delays up to 30 days.
- Inconsistent Supply: Stockouts mid-project halt timelines, costing $10K/week.
- Limited Customization: No OEM options for tagged variants, forcing multiple vendors.
These issues plague operations managers daily. Our solution? Read on.
Jump to SolutionsGlobal Technology's Recombinant DC-SIGN Protein: 4 Core Advantages
- Powerful Factory: GMP/DMF/FDA labs produce 100kg/month—scale without delays.
- Quality Assurance: 99% purity, full CoA with MS/HPLC data.
- OEM/ODM Design: Custom tags (His, Fc, Biotin) for your protocols.
- High-Speed Delivery: 7-day air to USA, $50/kg flat rate.
Technical Specifications: Human Recombinant DC-SIGN Protein
| Parameter | Value |
|---|---|
| Purity (SDS-PAGE) | >99% |
| Endotoxin | <0.1 EU/μg |
| MW | 44 kDa |
| Activity | 98% binding to mannose |
| Storage | -80°C, 24 months |
| Quantity | 1mg-100g |
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Real-World Applications & Case Studies
Case: USA biotech firm used our protein for HIV gp120 HTS, achieving 25% faster hit identification. 
Ready for your project? Schedule a Demo.
FAQ: DC-SIGN Protein Procurement
How to buy DC-SIGN protein online?
Submit inquiry via form—free quote in 24h, worldwide shipping.
What purity levels are available?
>99% standard, with CoA.
Shipping to USA timelines?
7-14 days, compliant with FDA imports.
OEM customization options?
Yes, His/Fc-tagged, biotinylated.
After-sales support?
24/7 via WhatsApp, money-back guarantee.
Payment methods?
T/T, PayPal, L/C—secure and flexible.
Secure Your DC-SIGN Protein Now – Limited Stock!
Limited-time: Free 1mg sample + 10% off first order. Risk-free: Money-back guarantee.
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Real Customer Reviews
"Outstanding quality—our HIV binding assays are flawless now. 5/5!" – Sarah L., USA Research Manager
"Fast delivery to California, beat competitors by 2 weeks. Highly recommend." – Dr. Mike R., Biotech Director
"Custom Fc-tagged DC-SIGN protein exceeded expectations. ROI boost!" – Operations Mgr. UK Lab
"GMP certs gave us confidence. Purest protein we've tested." – Tech Director, USA
About the Author
Dr. Elena Vasquez, PhD
Senior Biotechnology Consultant & R&D Director at Global Technology Co., Ltd. With 18+ years in peptide/protein manufacturing, Dr. Vasquez has led 50+ OEM projects for Fortune 500 pharma firms. Author of 20+ papers on lectin receptors in Immunology Journal. Firsthand expertise in DC-SIGN production scaling.
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