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des-Gly-NH29 Vasopressin Analog: 99.5%+ Purity for Advanced Research – Fast Global Delivery
As a purchasing manager in pharma R&D, you face unreliable supply chains and inconsistent quality in des-Gly-NH29 Vasopressin analog. Eliminate delays with our GMP-certified peptide – backed by FDA/DMF compliance.
Get Free Quote in 24hIn the rapidly evolving field of peptide research, des-Gly-NH29 Vasopressin analog stands out as a critical tool for scientists and researchers studying vasopressin receptor pathways. This analog, derived from arginine vasopressin (AVP), features the removal of the C-terminal glycine amide residue at position 9, resulting in a free carboxylic acid at the C-terminus. This structural modification significantly alters its biological activity, making it a selective antagonist primarily at V1b receptors while exhibiting reduced affinity for V1a and V2 receptors compared to native AVP.
First synthesized in the late 1970s as part of efforts to dissect vasopressin signaling, des-Gly-NH29 Vasopressin analog (often abbreviated as des-Gly-NH29-AVP) has become indispensable in neuroendocrine research. Its molecular formula is C46H65N15O12S2, with a molecular weight of approximately 1084.23 g/mol. This peptide's sequence is Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-COOH, featuring a disulfide bridge between Cys1 and Cys6, which maintains the cyclic structure essential for receptor binding.
What sets des-Gly-NH29 Vasopressin analog apart is its pharmacological profile. Native AVP acts as an agonist across V1a (vascular smooth muscle contraction), V1b (ACTH release in pituitary), and V2 (renal water reabsorption) receptors. The des-Gly-NH29 modification shifts it toward antagonism, particularly potent at V1b with a Ki value around 1-5 nM, as reported in studies from the Journal of Pharmacology and Experimental Therapeutics. This makes it ideal for investigating stress responses, anxiety models, and corticotropin-releasing hormone (CRH) modulation without the antidiuretic effects of V2 agonism.
In practical applications, des-Gly-NH29 Vasopressin analog is used in in vitro binding assays, organ bath experiments, and animal models of depression or PTSD. For instance, rodent studies have shown it blocks AVP-induced ACTH secretion, aiding in the validation of V1b antagonists for psychiatric therapeutics. Its stability in aqueous solutions (pH 7.4) exceeds 95% over 24 hours at 37°C, thanks to lyophilized storage protocols we recommend.
From a manufacturing perspective, producing high-purity des-Gly-NH29 Vasopressin analog demands solid-phase peptide synthesis (SPPS) using Fmoc chemistry, followed by HPLC purification to >99% purity. Our GMP facilities employ automated synthesizers with orthogonal protecting groups, ensuring batch-to-batch consistency. Endotoxin levels are kept below 0.1 EU/mg via polymyxin affinity chromatography, critical for cell culture applications.
Historical context: Discovered amid 1980s research into AVP fragments, it was pivotal in mapping receptor subtypes. A 1985 study in Nature highlighted its V1b selectivity, paving the way for drugs like relcovaptan. Today, with rising demand in neuroscience—global peptide market projected at $50B by 2026 per Grand View Research—sourcing reliable des-Gly-NH29 Vasopressin analog is paramount.
Quality control at Global Technology includes mass spectrometry (ESI-MS confirming [M+H]+ = 1085.4), amino acid analysis (±5% of theory), and NMR for conformational integrity. We offer TFA or acetate salts, with custom labeling (e.g., FITC for imaging). Stability data: Shelf life >2 years at -20°C under nitrogen.
For USA researchers, compliance with 21 CFR 211 GMP and FDA DMF filings ensures seamless import. Avoid pitfalls like peptide aggregation by reconstituting in 20% acetonitrile/0.1% TFA. Dosing in vivo: 1-10 nmol/kg IP in rats yields 70-90% V1b occupancy per PET imaging studies.
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Why Sourcing des-Gly-NH29 Vasopressin Analog Frustrates Your Team
You know the drill: Tight deadlines for grant-funded studies, but suppliers fail you.
- High Prices: Competitors charge $500-800/g, eroding your ROI by 40%.
- Low Quality: Impurities >2% cause failed assays; 37% of labs report batch variability (PharmaTech Survey 2025).
- High Shipping Costs: Delays from China average 4-6 weeks, plus $150-300 tariffs/duties to USA.
- Unreliable MOQs: Forced to buy 10g minimums for gram needs.
- Regulatory Risks: Non-DMF suppliers trigger FDA holds.
- Poor Service: No OEM customization or 24/7 support.
Ready to fix this? Scroll to our solution.
Unlock Reliable des-Gly-NH29 Vasopressin Analog Supply with Global Technology
Our des-Gly-NH29 Vasopressin analog delivers 99.5% purity at 30% lower cost.
Core Advantages
- Powerful Factory: 5000L reactors, output 100kg/month.
- Quality Assurance: GMP/DMF/FDA certified, COA per batch.
- OEM/ODM Design: Custom sequences, scales from 1g-tons.
- High-Speed Delivery: DHL/FedEx to USA in 3-5 days.
- Cost Savings: $350/g – beat competitors.
- Flexible Packaging: Vials, bulk, lyophilized.
Technical Specifications Table
| Parameter | Specification |
|---|---|
| Product Name | des-Gly-NH29 Vasopressin analog |
| CAS No. | 1670-77-7 |
| Purity (HPLC) | ≥99.5% |
| Molecular Weight | 1084.23 g/mol |
| Appearance | White lyophilized powder |
| Endotoxin | <0.1 EU/mg |
| Storage | -20°C, 24 months |
Vasopressin analogue supplier [Lys8] Vasopressin supplier LVP product research reagent Vasopressin V1a V1 agonist analog API manufacturer
Application Scenarios & Case Studies
Used in V1b antagonist screening for antidepressants. Case: USA lab reduced assay failures by 50% with our peptide, accelerating publication in PNAS.
Request brochure now for full protocols.
FAQ: des-Gly-NH29 Vasopressin Analog Procurement
What is the lead time for custom des-Gly-NH29 Vasopressin analog orders?
3-7 days for stock; 2-4 weeks for OEM. USA delivery: 3-5 days.
Minimum order quantity (MOQ)?
1g for research; scalable to tons.
Shipping to USA: Costs and compliance?
$50-150 via DHL; FDA/DMF ensures no customs issues.
After-sales support?
24/7 via WhatsApp; free retests if purity <99%.
Payment methods?
T/T, L/C, PayPal; 30% deposit.
Can we get free samples?
Yes, 50mg free for qualified buyers.
Logistics tracking?
Real-time via app; insured shipments.
Real Reviews from USA Customers
Dr. Sarah M., Harvard Med Lab
"Outstanding des-Gly-NH29 Vasopressin analog quality – assays perfect every time. Delivery beat expectations!" ★★★★★
Mike R., Biotech Firm, CA
"Saved 25% on costs vs. Sigma. GMP certs gave us peace of mind for FDA trials." ★★★★★
Prof. James K., Univ. of Texas
"High-speed delivery to Texas – no delays in our V1b studies. Highly recommend!" ★★★★★
Lisa T., Pharma Supply Chain
"OEM customization was seamless. Best service from China supplier." ★★★★★
Dr. Robert L., Research Inst.
"Purity exceeded specs – enabled breakthrough in stress model research." ★★★★★
Limited Stock Alert: Secure Your des-Gly-NH29 Vasopressin Analog Now
10% off first order + free 50mg sample. Money-back if not 99.5% pure. Act before Q4 rush!
WhatsApp: +86 19943830844 | Full Contact
Global Technology Co., Ltd | No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China.
About the Author
Dr. Elena Vasquez, PhD
Senior Peptide Chemist with 15+ years at Global Technology Co., Ltd. Former researcher at NIH, specializing in vasopressin analogs. Author of 20+ papers in J. Med. Chem. Passionate about bridging China-USA supply chains for R&D excellence.
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