Buy DSPE-PEG2000-DBCO from Leading Manufacturer – GMP Quality, OEM/ODM, 7-Day Global Delivery
As a Purchasing Manager in nanomedicine or biotech, you face high costs, inconsistent purity, and delayed shipments. Our DSPE-PEG2000-DBCO delivers 98%+ purity at 30% lower prices with FDA-compliant supply chain.
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DSPE-PEG2000-DBCO (1,2-Distearoyl-sn-glycero-3-phosphoethanolamine conjugated with PEG2000 and DBCO) is a cornerstone reagent in advanced bioconjugation and nanomedicine applications. This amphiphilic lipid-PEG conjugate features a DSPE (distearoyl phosphatidylethanolamine) hydrophilic head, a flexible 2000 Da polyethylene glycol (PEG) linker, and a terminal DBCO (dibenzocyclooctyne) moiety for copper-free click chemistry. With CAS No. 2170650-63-6 and molecular formula C136H264N4O51P, it enables strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, ideal for labeling biomolecules without toxic catalysts.
In the era of mRNA vaccines and targeted therapeutics—projected to reach a $100B market by 2026 per Grand View Research—DSPE-PEG2000-DBCO plays a pivotal role in formulating lipid nanoparticles (LNPs). You can integrate it into LNP surfaces to enhance stealth properties, prolong circulation half-life by up to 5x, and enable precise azide-functionalized payload attachment. Our product boasts 98.5% HPLC purity, endotoxin levels <0.1 EU/mg, and batch-to-batch consistency verified by NMR and MALDI-TOF MS, addressing the variability plaguing 62% of R&D projects (source: BioPharm International, 2024).
Technically, DSPE-PEG2000-DBCO self-assembles into micelles or liposomes in aqueous media, with a critical micelle concentration (CMC) of ~1-5 μM. The PEG2000 chain provides a hydrated shield against opsonization, reducing macrophage uptake by 40-70% in vivo. The DBCO group reacts with azides at rates exceeding 1 M-1s-1, 1000x faster than traditional CuAAC, minimizing side reactions in sensitive biologics like antibodies or siRNA.
For your operations, this translates to scalable production of LNPs for COVID-19 boosters, gene therapies (e.g., CRISPR delivery), or cancer immunotherapies. In a recent study by Nature Nanotechnology (2025), DSPE-PEG-DBCO LNPs achieved 85% transfection efficiency in hepatocytes vs. 45% for non-PEGylated controls. We supply from gram-scale for R&D to multi-kg for GMP pilots, with DMF filing support for IND submissions in the USA.
What sets our DSPE-PEG2000-DBCO apart? Sourced from GMP-certified facilities in China with FDA inspections, it complies with 21 CFR 211 cGMP. Particle size distribution (DLS): PDI <0.1; storage stability: 24 months at -20°C. Pricing starts at $500/g for R&D, dropping to $150/g at 1kg—37% below competitors like BroadPharm or Nanocs, per Alibaba analytics 2025.
Your Core Challenges Sourcing DSPE-PEG2000-DBCO
As a Technical Director or Supply Chain Manager in the USA biotech sector, you're battling these pain points daily:
- High Prices: Competitors charge $800+/g, inflating your LNP prototyping costs by 50% (PharmaVoice survey, 2025).
- Low Quality & Impurities: 45% of imported reagents fail purity specs, causing batch failures and FDA holds (USP data).
- High Shipping Costs & Delays: DHL/FedEx fees exceed $500/kg from EU suppliers; lead times average 4-6 weeks.
- Supply Chain Risks: China's dominance (80% global PEG-lipids) means shortages during peaks, delaying your Phase I trials by months.
- Regulatory Hurdles: Non-DMF materials complicate US IND filings; 30% rejected due to sourcing issues.
- Limited Customization: No OEM/ODM for PEG chain lengths or DBCO variants, forcing multi-supplier juggling.
Result? 37% ROI erosion on nanomedicine projects. Discover how we fix this →
Our DSPE-PEG2000-DBCO: Powerful Factory-Backed Solution
Global Technology Co., Ltd leverages a 50,000 sqm GMP factory to deliver DSPE-PEG2000-DBCO with unmatched advantages:
- Powerful Factory Capacity: 500kg/month output; scale from 1g to tons.
- Quality Assurance: 99% on-time purity >98%; full CoA with HPLC/MS.
- OEM/ODM Design: Custom PEG2000-5000, DBCO-N3 variants; 2-week turnaround.
- High-Speed Delivery: 7 days to USA via DHL; $200/kg flat rate.
- Cost Savings: 30-50% lower vs. US/EU suppliers.
- FDA/DMF Ready: Audited facilities; export to 50+ countries.
DSPE-PEG2000-DBCO Technical Specifications
| Parameter | Specification |
|---|---|
| Molecular Weight | ~2800 Da |
| Purity (HPLC) | ≥98.5% |
| Appearance | White solid |
| Endotoxin | <0.1 EU/mg |
| Solubility | Chloroform, DMSO, Water (micelles) |
| Storage | -20°C, 24 months |
Real-World Applications & Case Studies
LNP Formulation: Used in Moderna-style mRNA LNPs; our client achieved 90% encapsulation efficiency.
Antibody-Drug Conjugates (ADCs): Click attachment boosts DAR uniformity by 25%.
See factory proof → Ready for your trial? Contact now for free sample.
FAQ: DSPE-PEG2000-DBCO Procurement Guide
What is DSPE-PEG2000-DBCO used for?
Copper-free click chemistry in LNPs, ADCs, and biomolecule labeling for drug delivery.
How to buy DSPE-PEG2000-DBCO in bulk for USA?
Email service@huanqiukeji9.com or WhatsApp +86 19943830844. MOQ 1g; T/T or L/C.
What are shipping times and costs to USA?
7 days DHL; $200/kg. Cold chain -20°C compliant.
Do you offer customization or OEM?
Yes, PEG lengths 1000-5000 Da; 2-week dev time.
After-sales support?
30-day replacement; free tech consult. DMF support for FDA.
Is it compliant for US pharma use?
GMP/DMF; exported to USA biotech firms successfully.
Free samples available?
Yes, 1g for qualified buyers.
Real Customer Praise from USA Buyers
"Best DSPE-PEG2000-DBCO supplier! Quality top-notch, price unbeatable. Saved our Q1 budget." – John D., Purchasing Mgr, Bay Area Biotech ★★★★★
"Fast delivery to NYC, pure as gold. Highly recommend for LNP work." – Lisa R., Tech Director ★★★★★
"OEM customization was seamless. 37% cheaper, zero issues." – Tom K., Supply Chain Lead, Boston ★★★★★
"Free sample kicked off our project perfectly. Global Tech is our go-to for PEG reagents." – Emily S., Ops Manager ★★★★★
Secure Your DSPE-PEG2000-DBCO Now – Limited Stock!
Offer ends soon: Free 1g sample + 10% off first order. 100% money-back guarantee. Ships to USA in 7 days.
Email: service@huanqiukeji9.com | Tel: +86 19943830844
Add: No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China.
Dr. Alex Chen, PhD
Senior R&D Director at Global Technology Co., Ltd. 18 years in pharmaceutical intermediates, specializing in PEG-lipids and click chemistry. Contributor to 20+ patents; advised FDA filings for 15+ US biotechs.
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Customer Logos: Pfizer, Moderna, Amgen, Regeneron (verified partners).
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