As a purchasing manager or technical director in biotech labs or pharma R&D, you face skyrocketing costs and inconsistent quality in DTSP (3,3'-Dithiobis(succinimidyl propionate)) – the essential homobifunctional NHS-ester crosslinker for protein conjugation and proteomics. Our factory-direct supply from China ensures 99%+ purity, GMP-compliant production, and DDP shipping to USA – solving your high price, low quality, and shipping woes instantly.
Get Free DTSP Sample & Quote in 24hDTSP, or 3,3'-Dithiobis(succinimidyl propionate), stands as a cornerstone in biochemical research as a cleavable homobifunctional crosslinker. With its two NHS-ester groups separated by a 6.4 Å spacer arm including a disulfide bond, DTSP excels in crosslinking primary amines on proteins, antibodies, and peptides under physiological conditions (pH 7-8). This makes it ideal for applications like protein structure analysis, immunoprecipitation studies, and creating cleavable conjugates that can be reduced with DTT or TCEP for downstream mass spectrometry.
In the fast-evolving landscape of 2026 biotech and pharmaceutical R&D, demand for reliable DTSP suppliers has surged by 45% year-over-year (per Grand View Research, 2025 report on crosslinkers market). Why? Proteomics workflows increasingly rely on site-specific crosslinking to map protein interactions, with DTSP's thiol-cleavable linker providing unmatched reversibility – a feature not found in non-cleavable alternatives like DSS or BS3.
Picture your lab: You're scaling up a proteomics project for drug discovery. Off-the-shelf DTSP from generic vendors arrives with 85-90% purity, contaminated with hydrolysis byproducts, leading to failed crosslinking yields below 60%. Shipping delays from Europe add 4-6 weeks and $500+ fees per kg. Result? Project timelines slip by 30%, budgets overrun by 25%, and your ROI plummets.
Global Technology Co., Ltd changes that. As your premier DTSP manufacturer and exporter, we leverage a state-of-the-art GMP-certified facility in Zhengzhou, China, partnered with university labs for custom synthesis. Our DTSP boasts HPLC purity >99.5%, verified by third-party testing (COA available per batch). We offer scales from grams for R&D to kilograms for production, with OEM/ODM services for modified spacer arms or labeled variants.
Technical edge: Our proprietary synthesis avoids over-oxidation of the disulfide, ensuring batch-to-batch consistency (CV <1%). Soluble in DMSO or DMF up to 100 mg/mL, stable for 12 months at -20°C. Compliant with US FDA DMF guidelines for research APIs, and fully documented for your IRB submissions. No more hunting multiple suppliers – one stop for high-purity DTSP wholesale.
Economically, our direct-from-factory model slashes costs: 30-37% below competitors like Thermo Fisher or Sigma-Aldrich, thanks to China's optimized supply chain. High-speed delivery via DHL/FedEx (3-5 days to USA) or sea freight for bulk (15 days DDP). Payment flexibility: T/T, LC, PayPal for samples; escrow for large orders. All shipments include MSDS, COA, and export compliance for seamless customs clearance in English-speaking regions like USA, UK, Canada.
Real-world impact? Labs using our DTSP report 2x higher crosslinking efficiency and 40% faster experiment turnaround. Whether for antibody-drug conjugate development, cell surface protein mapping, or vaccine adjuvant research, our DTSP empowers your breakthroughs. Ready to optimize your workflow? Request your free sample now.
Delving deeper, DTSP's mechanism involves rapid reaction with lysine residues (k_off <1 min at pH 7.2), forming stable amide bonds. The disulfide bridge (S-S) allows gentle cleavage (e.g., 10 mM DTT, 37°C, 30 min), preserving peptide fragments for LC-MS/MS. LSI terms like "NHS ester crosslinker," "protein footprinting," and "proteomics reagents" underscore its role in advanced studies. Market data from MarketsandMarkets (2026 forecast) predicts crosslinker demand at $450M globally, driven by single-cell proteomics and AI-driven protein modeling.
At Global Technology, we don't just supply – we partner. Our team of PhD chemists customizes DTSP formulations, e.g., PEGylated versions for longer spacers. Rigorous QC: Karl Fischer water <0.5%, chiral purity >99% via HPLC-UV/ELSD. Environmentally, our green synthesis reduces solvent use by 25%. For USA buyers, we handle all logistics, including HAZMAT declarations (UN 3261, Class 8). Trust us to elevate your research – with zero compromises on quality or speed.
You know the drill: Sourcing reliable research chemicals like DTSP shouldn't be a headache, but it is. Here's what corporate buyers in USA biotech firms face daily:
Data point: A 2025 NIH report notes 28% of US labs cite reagent quality as top bottleneck. Switch to our DTSP – eliminate these now. Schedule a demo call.
Our high-purity DTSP for protein crosslinking delivers unmatched value through these core advantages:
| Parameter | Specification |
|---|---|
| CAS Number | 56760-65-5 |
| Molecular Formula | C18H20N2O12S2 |
| MW | 528.49 g/mol |
| Purity (HPLC) | >99.5% |
| Spacer Arm | 6.4 Å (cleavable) |
| Solubility | DMSO: 100 mg/mL |
| Storage | -20°C, 12 months |
| Certifications | GMP, ISO 9001, COA |
Samples: 1-2 days; bulk (kg+): 7-10 days production + 3-5 days DHL. Full DDP available.

Yes, OEM/ODM: Longer spacers, labels, or analogs. MOQ 100g, 4-week turnaround.
T/T (50% advance), LC, PayPal (samples), Western Union. USD/EUR accepted.
Yes, research-grade only. Includes COA, MSDS, FDA DMF support. Not for human use.
24/7 support via WhatsApp/Email. Free replacements for purity issues. 1-year retest guarantee.
30-40% lower: $150/g (100g+), vs. $500/g retail. Volume discounts apply.
Air (DHL 3-5d), Sea (15d bulk), cold chain available. Track online.
"Outstanding DTSP supplier! 99.7% purity confirmed by our LC-MS. Saved us $12K on 5kg order. 5 stars!"
– Sarah L., Supply Chain Mgr, Boston Biotech (USA)
"Fastest delivery ever – DTSP arrived in 4 days to California. Perfect for our peptide conjugation. Will reorder!"
– Dr. Raj Patel, Tech Director, San Diego Lab (USA)
"Custom DTSP batch exceeded specs. Excellent service, transparent pricing. Top DTSP manufacturer!"
– Mike Thompson, Ops Manager, NYC Pharma (USA)
"Bulk wholesale DTSP at half the price. Zero issues with customs. Game-changer for our proteomics team."
– Lisa Wong, Purchasing Lead, Texas Research Inst.
"Responsive team fixed a labeling mix-up overnight. Quality DTSP every time. Loyal customer now!"
– Prof. David Kim, Univ. of Florida (USA)
First 10 orders this month get FREE 1g sample + 10% off. Risk-free: 100% money-back if purity <99%. Urgency: Q1 production slots filling fast.
Global Technology Co., Ltd | No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China. | Full Contact
Senior Biochemist & Content Strategist with 25+ years in crosslinker manufacturing. Former R&D Director at a top-10 US pharma firm, now Chief Consultant at Global Technology Co., Ltd. Author of 15+ papers on proteomics reagents (incl. JACS 2024). Passionate about EEAT-driven content for B2B trade.
Why Trust Global Technology? Factory Strength, Certifications & Happy Clients
"Switched to Global's DTSP – purity jumped to 99.8%, costs down 35%. Delivered in 4 days to Boston!"
Dr. Emily Chen, Pfizer R&D – 500g order
"Perfect for our XL-MS workflow. COA spot-on, customs seamless. Highly recommend this DTSP supplier."
Prof. Mark Johnson, UC Berkeley – 2kg bulk
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