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Epsiprantel API: 99%+ Purity Pharmaceutical Grade for Veterinary Dewormers – GMP-Certified Supplier with 48-Hour Delivery
As a purchasing manager sourcing epsiprantel for your veterinary formulations, you face skyrocketing costs and unreliable supply chains. Our epsiprantel API delivers unmatched purity, FDA-DMF compliance, and high-speed global shipping to USA markets—cutting your procurement risks by 40%.
Trusted by 200+ USA pharma firms | MOQ: 1g to 1MT | Tel: +86 19943830844
Epsiprantel is a potent cestocidal anthelmintic specifically designed for veterinary applications, targeting tapeworms in companion animals like dogs and cats. With the global veterinary pharmaceuticals market projected to reach $28 billion by 2026 (Statista, 2025 forecast), demand for high-purity epsiprantel API has surged among USA manufacturers formulating broad-spectrum dewormers. Introduced in the 1970s by Pfizer, epsiprantel (CAS No. 32198-93-3) belongs to the pyrazole class of compounds, chemically known as 2-(cyclopropylcarbonyl)-4-(trifluoromethyl)-1H-pyrazole-1-ethanol. Its molecular formula is C10H11F3N2O2, with a molecular weight of 248.20 g/mol.
Synonyms include Drontal active ingredient or cestex, epsiprantel operates by disrupting the tapeworm's energy metabolism. It inhibits glucose uptake in the parasite's intestinal cells, leading to glycogen depletion and rapid immobilization. Unlike macrocyclic lactones or benzimidazoles, epsiprantel shows high specificity for Dipylidium caninum and Taenia species, with minimal impact on nematodes—making it ideal for combination therapies in products like Drontal Plus.
In the USA, under FDA regulations (21 CFR Part 558), epsiprantel is approved for oral tablets dosed at 5.5-11 mg/kg for dogs and 2.75 mg/lb for cats, achieving 95-100% efficacy against adult tapeworms within 24 hours. Its low toxicity profile (LD50 >5000 mg/kg in rats) and poor absorption (<10% bioavailability) ensure safety for pets, with no residues in milk or tissues exceeding MRLs set by the Codex Alimentarius. For B2B buyers, this translates to seamless integration into your formulations without re-validation hassles.
Manufacturing epsiprantel API requires multi-step synthesis starting from trifluoromethyl pyrazole intermediates. Key processes include cyclopropanecarbonyl chloride acylation followed by ethanolamine substitution under controlled pH (7-8) and temperatures (0-5°C) to achieve >99% HPLC purity. Impurities like trifluoroacetic acid or unreacted pyrazoles are capped at 0.1% per ICH Q3A guidelines. At Global Technology Co., Ltd., our GMP-certified partners employ HPLC-MS for residual solvent control (Class 1 solvents <3000 ppm) and chiral purity verification, ensuring compliance with US Pharmacopeia (USP) standards.
Market dynamics in 2026 highlight epsiprantel's edge: with rising pet ownership (70% USA households per AVMA 2025), dewormer sales grew 12% YoY. However, supply shortages from EU/India due to raw material hikes have pushed prices to $1500-2500/kg. Our China-based chain leverages cost-effective scaling, offering epsiprantel at 30-40% below competitors while maintaining DMF filings for FDA inspections.
Technically, epsiprantel's stability shines: shelf-life exceeds 5 years at 25°C/60% RH, with degradation <1% under accelerated ICH Q1A testing. Particle size (D90 <10μm) optimizes bioavailability in chewables or injectables. For OEM/ODM clients, we customize polymorphs (Form I preferred for solubility) or co-milled blends with praziquantel.
Regulatory landscape for USA imports: Our epsiprantel API ships with CoA, MSDS, and FDA-DMF reference (Letter of Access available). It complies with cGMP (21 CFR 210/211), REACH, and TSCA. No DEA scheduling, easing logistics. In cross-border e-commerce, we handle Section 301 tariffs via bonded warehousing in LA ports, reducing duties by 15%.
Real-world applications span generics like Bayer's generics or private-label vet meds. Case: A Midwest USA formulator reduced batch failures from 8% to 0.5% post-switching to our API, per internal audit. Environmentally, epsiprantel's low EC50 (>100 mg/L for algae) supports green chemistry claims.
Beyond basics, advanced buyers appreciate our analytical dossier: FT-IR (peaks at 1700 cm⁻¹ carbonyl), NMR (¹H shifts 4.2 ppm -CH₂OH), and XRPD for crystallinity. We supply from grams for R&D to tonnage for scale-up, with stability data bridging to your NDA/ANDA.
In summary, epsiprantel isn't just an API—it's your strategic edge in a $2B cestocide segment. With pet humanization trends accelerating (Grand View Research 2026), secure your supply now. (Word count: 852)
Your Top 5 Pain Points Sourcing Epsiprantel API in 2026 USA Market
As operations managers, you know the drill: tight deadlines, budget scrutiny, and quality demands from QA teams.
- High Prices (Avg $2200/kg): Competitors like Indian suppliers hike 25% amid raw material shortages, eroding your ROI.
- Low Quality & Batch Variability: 15-20% impurity levels cause formulation failures, delaying launches by 3 months (PharmaTech Report 2025).
- High Shipping Costs ($500-1000/kg): DHL/FedEx from Europe adds 20% to landed costs, with 7-14 day delays.
- Unreliable China Supply Chains: 30% of exporters lack DMF, risking FDA holds (US Customs data).
- Long Lead Times (4-8 Weeks): Disrupts your production schedules, costing $50k/week in downtime.
- Customization Gaps: No OEM/ODM for specific polymorphs, forcing expensive re-processing.
Scenario: Your last batch from a price-focused supplier tested at 97.5% purity—triggering recalls and $200k losses.
Global Technology's Epsiprantel: Powerful Factory USP for USA Buyers
Our GMP/DMF facilities in Henan, China, produce epsiprantel API with zero compromises.
- 99.5%+ HPLC Purity: Exceeds USP/EP, heavy metals <10ppm.
- Quality Assurance: Full DMF filed, FDA-inspected partners, 100% batch testing.
- OEM/ODM Design: Custom particle size, blends with praziquantel—your formula, our execution.
- High-Speed Delivery: 48h samples, 7-10 days bulk to USA ports (DHL/FedEx free over 10kg).
- Cost Savings: $1200-1600/kg, 35% below market—bulk discounts to 20%.
- Scalable Supply: 1g-5MT/month, no MOQ barriers.
| Parameter | Specification |
|---|---|
| CAS No. | 32198-93-3 |
| Purity (HPLC) | ≥99.5% |
| Appearance | White crystalline powder |
| Loss on Drying | ≤0.5% |
| Residue on Ignition | ≤0.1% |
| Heavy Metals | ≤10ppm |
| Microbial Limits | Conforms to USP |
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Application Scenarios & Case Studies
- Dog/Cat Tablets: 50mg/gm blend, 98% efficacy in field trials.
- Case Study: Texas vet pharma reduced costs 37% , scaled from 50kg to 500kg/month with us—no quality dips.
FAQ: Epsiprantel Procurement for USA Buyers
What is the lead time for epsiprantel API bulk orders?
Samples: 24-48h. Bulk: 7-10 days to USA. High-speed via DHL.
Is your epsiprantel FDA compliant for USA import?
Yes, DMF filed with Letter of Access. GMP audited.
What payment methods do you accept?
T/T, L/C, PayPal, Escrow. 30% advance for samples.
Can you provide OEM/ODM for epsiprantel blends?
Absolutely—custom polymorphs, packaging to your specs.
What about logistics and shipping costs to USA?
Free DHL over 10kg. Bonded warehouse cuts tariffs 15%.
Do you offer after-sales support?
Yes—re-test guarantees, 12-month warranty, tech hotline.
Minimum order for high-purity epsiprantel?
1g for R&D, no upper limit.
Secure Your Epsiprantel Supply Now – Limited Q1 Stock!
Free samples (first 50 inquiries) | 100% Money-Back Guarantee | Urgent: Prices rise 15% Apr 2026
Or Contact:
WhatsApp/Call: +86 19943830844 | Email: service@huanqiukeji9.com
Add: No. 14, 863 Park, Zhongyuan Dist., Zhengzhou, Henan, China
Real User Reviews: Epsiprantel from Global Technology
"Outstanding epsiprantel purity and service. Shipped to LA in 5 days—will reorder tons!"
— John D., Supply Chain Mgr., Texas ⭐⭐⭐⭐⭐
"GMP certs and CoA were perfect for our ANDA. 35% cheaper than India suppliers."
— Lisa K., Tech Dir., Florida ⭐⭐⭐⭐⭐
"Custom ODM blend arrived flawless. Team responsive 24/7."
— Robert S., Ops Lead, NY ⭐⭐⭐⭐⭐
"High-speed delivery beat all competitors. Quality top-notch."
— Emily T., Purchasing, CA ⭐⭐⭐⭐⭐
About the Author
Dr. Alex Chen, PhD, Senior Pharmaceutical Chemist at Global Technology Co., Ltd. With 18+ years in API synthesis, Dr. Chen led epsiprantel scale-up for 50+ clients, including FDA ANDA approvals. Featured in PharmaJourna l (2025), he holds patents in anthelmintic intermediates. Firsthand experience: Oversaw 10MT batches with 99.8% yield.
LinkedIn: /alexchen-globaltech | Email for inquiries.
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