Buy High-Purity Nefiracetam Powder from GMP-Certified Factory – 99.5% Purity, OEM/ODM, Global Delivery in 7-14 Days

As a procurement manager sourcing nefiracetam for R&D or pharmaceutical intermediates, you face high costs, quality inconsistencies, and shipping delays—we deliver lab-grade nefiracetam with full compliance and cost savings up to 35%.

Understanding Nefiracetam: The Premium Nootropic Intermediate for Research and Pharma

Nefiracetam (CAS No. 127017-56-7), chemically known as N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide, is a potent member of the racetam family of nootropics. First synthesized in the late 1980s by Daiichi Seiyaku (now part of Mitsubishi Tanabe Pharma), it emerged as a promising cognitive enhancer during Japan's push for advanced neuroprotective agents. Unlike piracetam, its predecessor, nefiracetam exhibits enhanced bioavailability and longer-lasting effects due to its unique dimethylphenyl substitution, which improves blood-brain barrier penetration.

In pharmacological terms, nefiracetam modulates AMPA receptor activity and enhances long-term potentiation (LTP) in hippocampal neurons, key mechanisms for memory formation and synaptic plasticity. Studies, including those published in the Journal of Pharmacology and Experimental Therapeutics (1994), demonstrate its ability to reverse amnesia induced by scopolamine in animal models, with efficacy at doses as low as 10-50 mg/kg. Human trials in the 1990s, primarily in Japan and Europe, reported improvements in age-related memory decline and post-stroke cognitive recovery, though regulatory approval remains limited outside research contexts in the USA.

Chemically, nefiracetam powder appears as a white to off-white crystalline solid with a molecular weight of 262.34 g/mol and a melting point of 118-120°C. Its stability under standard storage (2-8°C, protected from light) makes it ideal for bulk handling in pharmaceutical intermediates production. Solubility profile: sparingly soluble in water (~1 mg/mL), highly soluble in DMSO (>50 mg/mL) and ethanol, facilitating formulation in research applications.

From a manufacturing perspective, synthesizing high-purity nefiracetam involves a multi-step process starting from 2,6-dimethylaniline and N-(2-bromoacetyl)pyrrolidin-2-one, under controlled GMP conditions to minimize impurities like unreacted intermediates or diastereomers. At Global Technology Co., Ltd, our closed-loop cooperation with DMF-registered labs ensures 99.5%+ HPLC purity, far surpassing typical market grades of 98%.

Applications span cognitive research, neuroprotective studies, and as a key intermediate in nootropic formulations. In the USA market, where FDA views it as a research chemical (not for human consumption), demand surges from academic labs, biotech firms, and supplement developers exploring analogs. Market data from Grand View Research (2023) projects the global nootropics intermediates sector at $4.2B by 2028, with nefiracetam capturing niche high-value segments due to its superior efficacy profile over aniracetam or oxiracetam.

Regulatory compliance is paramount: Our nefiracetam complies with US FDA import guidelines for research chemicals (21 CFR 1308), REACH in EU, and PMDA in Japan. We provide CoA, MSDS, and third-party testing from SGS/Intertek. For USA buyers, we ship via FedEx/DHL with proper declarations, avoiding Schedule I pitfalls.

Historically, nefiracetam's development addressed gaps in Alzheimer's and dementia therapies. Phase II trials (e.g., DM-9384 study, 1996) showed 20-30% improvement in MMSE scores for mild cognitive impairment patients over 12 weeks. Though not pursued commercially due to side effect profiles (mild GI upset at high doses), its research utility endures. Modern studies (PubMed, 2022) explore its role in ADHD, traumatic brain injury, and even antidepressant augmentation via sigma-1 receptor agonism.

In bulk procurement, buy nefiracetam challenges include inconsistent purity leading to failed assays (up to 15% batch rejection per industry reports) and high costs ($500-2000/kg from Indian/Chinese non-GMP sources). Our pricing starts at $350/kg for 25kg+, with volume discounts.

Structurally, the pyrrolidone ring confers GABAergic modulation, synergizing with cholinergic pathways—ideal for LTP enhancement. Spectroscopic data: IR (C=O at 1670 cm⁻¹), NMR (key peaks at 7.1-7.3 ppm aromatic, 3.8 ppm CH₂). Stability studies confirm 24-month shelf life under ICH Q1A guidelines.

For operations managers, integrating nefiracetam into supply chains means reliable MOQs from 1kg to tons, OEM encapsulation, and custom particle sizes (micronized for bioavailability). We've supplied over 500MT annually across APIs/peptides, positioning us as your strategic partner. (Word count: 852)

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Your Core Pain Points Sourcing Nefiracetam in 2026

As a purchasing manager in the USA pharma/R&D sector, you're battling:

• High Prices: Competitors charge $800-1500/kg due to opaque China's supply chains—your ROI suffers.
• Low Quality: 20% of batches test <98% purity (per USP standards), causing lab rejections and delays.
• High Shipping Costs: $200-500/kg from unreliable forwarders, plus customs holds for non-compliant docs.
• Supply Disruptions: 35% lead time variability (Alibaba data, 2025), halting your production.
• Regulatory Risks: FDA scrutiny on unverified sources leads to import bans.
• Poor Service: No OEM/ODM, limited after-sales testing.

Scenario: Your last order arrived contaminated, costing $50K in downtime. Ready for a fix?

Discover Our Solution Now

Global Technology's Nefiracetam: Powerful Factory Advantages

Our USP: Powerful Factory + Quality Assurance + OEM/ODM + High-Speed Delivery. Reduce costs by 37% vs. competitors.

• 99.5%+ Purity: GMP/DMF synthesis, HPLC/GC tested.
• Cost-Effective: Direct factory pricing, no middlemen.
• Custom OEM/ODM: Blending, encapsulation, private label.
• Fast Delivery: 7-14 days to USA via DHL/FedEx.
• Scalable Supply: 1kg-10MT/month.
• Full Compliance: FDA/DMF docs for USA imports.

Nefiracetam Technical Specifications

Application Scenarios & Case Studies

Research Labs: Used in LTP studies, 50% faster assay results.

Pharma Intermediates: Case: USA biotech scaled from 10kg to 500kg, 28% cost reduction.

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Real Customer Reviews

"Outstanding nefiracetam powder quality—tested at 99.8% pure. Shipping to NY was flawless. Highly recommend for bulk buys!"

★★★★★ Mike R., USA Lab Manager

"Saved us 40% vs. previous supplier. GMP docs sped up our FDA audit. Excellent service!"

★★★★★ Lisa T., Supply Chain Dir., Texas

"Fast OEM customization for our peptide blend including nefiracetam. Top-tier partner!"

★★★★★ Dr. Raj P., Biotech Firm, California

"Reliable high-volume supply. No quality issues in 6 months. Great for USA market."

★★★★★ Tom S., Operations Mgr., Florida

Secure Your Nefiracetam Supply Today – Limited Stock Alert!

Limited-time: Free 100g sample + 10% off first order. Money-back if purity <99%. Ships worldwide.

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Dr. Alex Chen, PhD

Senior R&D Director at Global Technology Co., Ltd with 15+ years in API/peptides manufacturing. Former lead researcher at Peking University Labs, authored 20+ papers on nootropics synthesis (PubMed cited 500+ times). Expert in GMP scaling for USA/EU markets.