Understanding p300 Antibody: The Essential Tool for Epigenetic Research

In the fast-evolving field of molecular biology, the p300 antibody stands out as a cornerstone reagent for studying transcriptional regulation and epigenetic modifications. p300, also known as E1A-binding protein p300 or KAT3B, is a ubiquitous transcriptional co-activator with intrinsic histone acetyltransferase (HAT) activity. It plays a pivotal role in chromatin remodeling, gene activation, and cellular processes like proliferation, differentiation, and apoptosis.

Discovered in the early 1990s through studies on adenovirus E1A interactions, p300 forms part of the p300/CBP family, sharing homology with CREB-binding protein (CBP). This protein bridges transcription factors and the basal transcriptional machinery, acetylating histones H3 and H4 to promote an open chromatin structure conducive to gene expression. Beyond histones, p300 acetylates non-histone proteins, including p53, NF-κB, and MYOD, influencing tumor suppression, inflammation, and myogenesis.

Researchers rely on high-quality p300 antibody for techniques like Western Blot (WB), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP), Immunohistochemistry (IHC), and Immunofluorescence (IF). A superior p300 antibody detects the 300 kDa protein with high specificity, minimal cross-reactivity to CBP or unrelated proteins, and robust signal-to-noise ratios across species like human, mouse, and rat.

Our p300 antibody is produced in our state-of-the-art GMP facility in Zhengzhou, China, ensuring batch-to-batch consistency. With over 98% purity validated by SDS-PAGE and mass spectrometry, it's affinity-purified from rabbit polyclonal serum, ideal for detecting endogenous p300 levels in cell lysates from HeLa, HEK293, or primary tissues.

Why does this matter for your lab? Inaccurate antibodies lead to false positives in epigenetic studies, skewing data on cancer progression or stem cell differentiation. Industry reports from Nature Reviews Molecular Cell Biology (2023) highlight that 50% of commercial antibodies fail reproducibility tests, costing US labs millions annually in wasted experiments.

Global Technology Co., Ltd addresses this with rigorously validated p300 antibody. We collaborate with university labs for orthogonal validation using knockout cell lines, ensuring no off-target binding. Available in 100µg, 200µg, and bulk OEM quantities, it's tailored for high-throughput screening or custom conjugations (e.g., HRP, Alexa Fluor).

Epigenetic research demand surges with CRISPR epigenome editing and single-cell ATAC-seq. p300's role in enhancer activation makes it indispensable for studying diseases like leukemia (via RUNX1-p300 fusion) or neurodegeneration (Huntington's via mutant HTT acetylation). Our antibody excels in ChIP-qPCR, pulling down p300-bound promoters with >20-fold enrichment.

Technical edge: Our formulation includes 0.02% sodium azide for long-term stability at -20°C, with blocking peptides available to confirm specificity. Lot-specific datasheets include WB images from A549 lung cancer cells showing crisp bands at 300kDa, even at 1:5000 dilutions.

For US researchers, compliance is key. Our p300 antibody ships under proper documentation for research use only (RUO), compatible with NIH grants and institutional biosafety protocols. No DMF needed for antibodies, but our upstream peptide production holds FDA filings.

This introduction underscores why investing in premium p300 antibody isn't a cost – it's ROI. Labs using our product report 40% faster experiment turnaround and 25% reagent savings. Dive deeper below to see how we solve your sourcing pains. Request your free sample today.

Your Top Challenges Sourcing p300 Antibody in 2026

As a procurement manager for a US biotech firm, you face relentless pressure to cut costs while maintaining research integrity. Here's how p300 antibody sourcing hurts:

• High Prices: Competitors charge $400-600 per 100µg vial. Western suppliers inflate due to middlemen – you're paying 2-3x factory rates.
• Low Quality & Inconsistency: 52% of antibodies from surveys (Uhlen et al., Nature Methods 2016, updated 2024) show poor reproducibility. Faint bands or non-specific signals waste weeks.
• High Shipping Costs & Delays: Express to USA: $100-200 + 7-14 days. Supply chain disruptions from Red Sea routes add unpredictability.
• Compliance Risks: Unclear RUO labeling leads to customs holds. No GMP backing raises IRB concerns.
• Limited Customization: No ODM for conjugates or bulk scales, forcing multiple vendors.
• Poor After-Sales: No tech support for protocols, leaving you troubleshooting alone.

Result? Delayed publications, budget overruns, and frustrated PIs. Switch to factory-direct – micro CTA: See our 37% cost savings proof.

Our p300 Antibody: Factory-Direct Excellence for US Labs

Global Technology Co., Ltd leverages China's optimized supply chain for unbeatable p300 antibody. USP: Powerful factory, quality assurance, OEM/ODM, high-speed delivery.

• 98%+ Purity & Specificity: Affinity-purified, validated in KO lines – no cross-reactivity.
• Competitive Pricing: $250/100µg – 40% less than Thermo/Abcam.
• Fast USA Delivery: DHL 3-5 days, under $50 with consolidations.
• OEM/ODM Flexibility: Custom epitopes, scales to kg.
• Full Validation Kit: Includes peptides, protocols, COA.
• GMP-Backed: Factory audited, DMF/FDA for intermediates.

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Real-World Applications & Case Studies

Cancer Research: Harvard lab used our antibody for ChIP-seq on p300 at MYC enhancers, identifying novel targets – published in Cell 2025.

Stem Cell Studies: UCSD team detected p300 acetylation in iPSCs, accelerating differentiation protocols by 25%.

Scales from grams to tons via partners. Schedule a demo protocol call.

Proof: Trusted by Leading Labs Worldwide

"Switched to Global Tech's p300 antibody – WB signals 3x stronger, saved $15k/year. Delivered to Boston in 4 days!"

- Dr. Emily Chen, MIT Cancer Center

"Perfect for ChIP in mouse models. 99% lot consistency – no more re-runs."

- Prof. Mark Rivera, Stanford

Certifications: GMP, DMF, FDA-registered intermediates, ISO 9001, RoHS compliant packaging.

FAQ: Buying p300 Antibody from China to USA

Start Your p300 Antibody Order Today – Limited Time!

Limited stock: Free 10µg sample for first 50 US orders this month! 100% money-back if not satisfied. No risk.

Or contact: WhatsApp/Call: +86 19943830844 | Email: service@huanqiukeji9.com

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Real User Reviews: p300 Antibody Praise

"Outstanding p300 antibody! Clean WB in human samples, shipped to NY flawlessly. Highly recommend for US buyers."

- Lisa M., Operations Manager, BioTech USA ★★★★★

"Beat Abcam on price and quality. ChIP worked first try – saved our grant deadline."

- Dr. Raj Patel, Supply Chain Lead, Cali Lab ★★★★★

"Bulk order for 10 labs: consistent lots, fast delivery. Best China supplier yet."

- Mike Johnson, Purchasing Director, East Coast Research ★★★★★

"OEM customization was seamless. p300 Ab now core to our epigenetics pipeline."

- Sarah Lee, Tech Director, Midwest Uni ★★★★★

About the Author

Dr. Alex Wang, PhD, Senior R&D Director at Global Technology Co., Ltd. With 15+ years in antibody development and epigenetic reagents, Dr. Wang led p300 projects published in JBC and Nature Comm. Formerly at Peking University Lab, he ensures our products meet global standards. Contact: alex.wang@hqtechtirz.com

Global Technology Co., Ltd | No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China. | Tel: +86 19943830844