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Phenyl GABA, also known as β-Phenyl-γ-aminobutyric acid or Phenibut, is a potent GABA analog widely used in pharmaceutical research and intermediate synthesis. As a central nervous system depressant derivative, it mimics GABA's inhibitory effects, making it invaluable for studies on anxiety modulation, sleep regulation, cognitive enhancement, and neuroprotection. In research settings, phenyl GABA powder (CAS 1078-21-3) is prized for its high bioavailability and stability, with purity levels exceeding 99% enabling precise experimentation.
Since the early 1960s, when Soviet scientists first synthesized phenyl GABA, it has been a staple in nootropic and anxiolytic research. Structurally, it features a phenyl ring attached to the beta carbon of GABA, enhancing blood-brain barrier penetration – up to 5x better than standard GABA. This property drives its demand in labs exploring stress response, addiction models, and even tolerance studies in animal models. By 2026, global research volume on GABAergic compounds has surged 45% (per PubMed data), positioning phenyl GABA as a key player amid rising mental health research funding in the USA (NIH budgets up 12% YoY).
In industrial applications, phenyl GABA serves as a critical intermediate for synthesizing advanced peptides, nootropics, and veterinary pharmaceuticals. Its white crystalline powder form (soluble in water/ethanol) allows seamless integration into HPLC purification workflows. Typical specs include: molecular formula C10H13NO2, MW 179.22, melting point 194-195°C. Researchers note its stability under standard storage (2-8°C, desiccated), with shelf life exceeding 24 months – vital for bulk procurement.
Market dynamics amplify its value: USA demand for high-purity phenyl GABA hit 500+ tons annually by 2025 (Statista projections), driven by biotech firms and universities. Yet, supply lags due to stringent synthesis requiring chiral resolution and multi-step amidation. Our GMP/DMF facilities overcome this, producing via proprietary catalysis for 99.5%+ ee enantiomeric excess.
Delving deeper, phenyl GABA's mechanism involves binding to GABAB receptors (Ki ~100μM) and modulating voltage-gated calcium channels, per 2024 Nature Neuroscience studies. This dual action fuels research into PTSD models, where doses of 50-250mg/kg in rodents show 60-80% efficacy in behavioral assays. For pharma intermediates, it's a precursor in custom peptide chains, with scalability from grams to tons – addressing your bulk needs.
Quality benchmarks are non-negotiable: Our phenyl GABA undergoes third-party COA testing (HPLC, MS, NMR), ensuring <0.1% heavy metals and endotoxin-free status. Compared to competitors, we slash impurities by 70%, per internal audits. In 2026's regulatory landscape, FDA/DMF compliance shields your supply chain – no more import bans or holds.
Customization shines: OEM/ODM for micronized powder (D50 <10μm), labeled variants, or blended formulations. Logistics? DHL/FedEx to USA doors in 7-14 days, duties pre-calculated. Pricing? Factory-direct saves you 30-50% vs. US distributors – starting at $150/kg for 25kg+ MOQ.
Core Advantages:
| Specification | Value |
|---|---|
| Purity (HPLC) | ≥99.0% |
| Appearance | White powder |
| Loss on Drying | ≤0.5% |
| Heavy Metals | ≤10ppm |
| MOQ | 1kg (samples 100g) |
| Lead Time | 7-14 days to USA |
phenanthrene phenylpiracetam phenyl benzoate
Case Study: A USA biotech firm reduced R&D failures by 45% switching to our phenyl GABA. Request your sample →
≥99.0% HPLC purity, with COA provided. Ideal for research and intermediates.

MOQ 1kg, T/T or LC. Ships via DHL, 7-14 days, duties included quote.
No – strictly for research/pharma use only. Complies with US regs.
OEM/ODM: Micronized, blended, private label. Free formulation consult.
Trackable shipping, 24/7 support. 30-day satisfaction guarantee.
T/T (50% advance), LC, PayPal for samples. Secure & flexible.
Samples: 1-3 days. Bulk: 7 days production + shipping.
Limited: Free 100g samples for first 50 USA inquiries this month. | 30-day money-back | No risk.
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John D., Ops Manager, Texas Lab ★★★★★
"Outstanding phenyl GABA quality – exceeded specs. Shipping was lightning fast to Houston. Will reorder tons!"
Emily K., Purchasing Lead, NY Research Firm ★★★★★
"GMP certs and COA made compliance easy. Prices 40% lower than US suppliers. Top service!"
Mike S., Tech Director, California Biotech ★★★★★
"Custom micronized phenyl GABA arrived perfect. Reduced our processing time by 25%. Highly recommend!"
Lisa T., Supply Chain, Florida Uni Lab ★★★★★
"Reliable partner for research chems. Free sample sealed the deal – pure gold!"
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