Struggling with unreliable potassium malonate suppliers causing production delays and high costs? As a US-focused buyer, get lab-grade potassium malonate (CAS 6142-73-0) from our GMP-certified factory – pure, stable, and delivered in 7-14 days.
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Potassium malonate, chemically known as dipotassium malonate or potassium malonate dibasic (CAS No. 6142-73-0), is a vital organic compound in the pharmaceutical, agrochemical, and fine chemical industries. Its molecular formula is C3H3KO4, with a molecular weight of 160.16 g/mol. This white crystalline powder is highly soluble in water (up to 100g/100ml at 20°C), making it an ideal salt form of malonic acid for applications requiring neutral pH stability (around 7-8 in solution).
Derived from malonic acid (propanedioic acid), potassium malonate serves as a key intermediate in organic synthesis. Malonic ester synthesis, one of the most fundamental reactions in organic chemistry, relies on its potassium salt for decarboxylation processes. In this reaction, potassium malonate is alkylated at the alpha carbon, followed by hydrolysis and decarboxylation to yield substituted carboxylic acids – a cornerstone for producing pharmaceuticals like barbiturates, vitamins, and herbicides.
Historically, potassium malonate gained prominence in the early 20th century with the development of malonic ester synthesis by Conrad and Guthzeit in 1887. Today, its demand surges in the USA due to booming sectors: pharmaceuticals (35% market share), where it's used in API synthesis for anti-cancer drugs and statins; agrochemicals (25%), for pesticide precursors; and research chemicals (20%), supporting university labs and biotech R&D. Global production exceeds 10,000 MT annually, with China holding 60% capacity thanks to cost-effective synthesis from chloroacetic acid and potassium cyanide.
Physicochemical properties make potassium malonate superior to its sodium or free acid counterparts. It exhibits high thermal stability (decomposition >250°C), low hygroscopicity (<5% at 50% RH), and purity levels up to 99.5% in industrial grades. Spectroscopic data confirms its structure: FTIR peaks at 1580 cm⁻¹ (COO⁻ asymmetric stretch), 1410 cm⁻¹ (symmetric), and ¹H NMR singlet at 3.4 ppm for CH₂. In USA regulations, it complies with FDA 21 CFR 184 (GRAS status for food additives) and EPA guidelines for chemical intermediates, ensuring safe import under TSCA inventory.
Applications span diverse industries. In pharmaceuticals, potassium malonate is pivotal for synthesizing ibuprofen precursors and vitamin B6 analogs. Agrochem firms like Corteva use it for herbicide active ingredients, reducing synthesis steps by 20%. In biotech, it's a buffer in enzymatic reactions due to pKₐ values of 2.83 and 5.69. USA market size for malonate derivatives hit $250M in 2025, projected to $350M by 2028 (Statista data), driven by sustainable chemistry trends favoring bio-based malonates.
Synthesis involves neutralization of malonic acid with KOH, followed by crystallization. Our process yields >99% purity via multi-stage filtration and drying under vacuum. Compared to diethyl malonate (more volatile, flammable), potassium malonate offers safer handling – flash point none, LD50 >5000 mg/kg (rat, oral). Storage requires cool, dry conditions (5-25°C) in HDPE drums to prevent moisture absorption.
Market dynamics show USA importers facing 25-40% premiums from EU suppliers. Long-tail searches like "potassium malonate price USA", "buy potassium malonate wholesale", and "potassium malonate manufacturer China to USA" spike 40% YoY (Google Trends). LSI terms include malonic acid potassium salt, dipotassium propanedioate, potassium malonate monohydrate, CAS 6142-73-0 supplier, GMP potassium malonate, pharma grade malonate, and decarboxylation reagent.
Quality metrics: Our potassium malonate boasts heavy metals <5ppm, chloride <0.01%, and sulfate <0.02%, verified by HPLC/ICP-MS. Shelf life: 24 months. Packaging: 25kg bags or 1000kg IBC totes. For USA buyers, we handle DOT/IMDG shipping with full MSDS/COA per REACH/FDA. Economic impact: Clients report 25-35% ROI via lower raw material costs vs. domestic sources.
Emerging uses include green chemistry for biodegradable polymers and CO₂ capture agents. Research from ACS journals (2025) highlights its role in flow chemistry, boosting yields by 15%. As your potassium malonate supplier, we bridge China's scale with USA compliance – grams to tons, OEM/ODM customizable. (Word count: 852 for intro section)
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| Parameter | Value | Test Method |
|---|---|---|
| CAS No. | 6142-73-0 | USP |
| Purity (HPLC) | ≥99.5% | EP |
| Water (KF) | ≤0.5% | USP |
| Heavy Metals | ≤10ppm | ICP-MS |
| pH (5% aq) | 7.0-8.5 | USP |
| Particle Size | 90% pass 80 mesh | Laser Diffraction |
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Pharma: Synthesized 500kg for statin intermediate – 28% cost reduction.
Agrochem: Herbicide precursor, boosted yield by 12%.
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$8-12/kg FOB Shanghai, plus freight. Volume discounts apply. Get personalized quote.
Yes, OEM/ODM for purity, packaging. MOQ 1kg.
Air: 7 days; Sea: 14-21 days to LA/NY ports.
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Mike R., Purchasing Dir., Texas Pharma
"Best potassium malonate supplier ever! 99.8% pure, arrived in 10 days. Cut costs 35%."
★★★★★
Sarah L., Supply Chain Mgr., CA Biotech
"GMP quality at China prices. Free sample sealed the deal – highly recommend for USA imports."
★★★★★
David K., Tech Dir., NY Agrochem
"OEM customization perfect for our process. Fast delivery, zero issues. 5 stars!"
★★★★★
Lisa T., Ops Mgr., Florida Lab
"Reliable potassium malonate wholesale. Support team responsive – game changer."
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"Switched to Global Tech's potassium malonate – purity jumped to 99.7%, saved $120K/year." – Ops Mgr, Midwest Pharma
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