Buy Probenecid API Wholesale: GMP-Certified, 99.9% Purity – Fast USA Delivery from China Factory

As a pharmaceutical purchasing manager or operations director in the USA, you face skyrocketing API costs, inconsistent quality, and delays in supply chains. Source probenecid from Global Technology Co., Ltd – cut costs by 30% with our powerful factory, full DMF/FDA compliance, and 7-14 day delivery.

What is Probenecid? Comprehensive Guide for Pharma Buyers

Probenecid (CAS No. 57-66-9) is a synthetic uricosuric agent and renal tubular secretion inhibitor widely used in pharmaceutical manufacturing. Chemically known as 4-(dipropyl sulfamoyl) benzoic acid, it has the molecular formula C₁₃H₁₉NO₄S and a molecular weight of 285.36 g/mol. Appearing as a white to off-white crystalline powder, it is sparingly soluble in water but freely soluble in alcohol and alkaline solutions.

Discovered in the 1940s by researchers at Sharp & Dohme, probenecid was first approved by the FDA in 1951 for treating hyperuricemia and gouty arthritis. Its mechanism of action revolves around blocking the renal tubular reabsorption of uric acid via inhibition of the URAT1 transporter in the proximal tubule. This increases urinary excretion of uric acid, reducing serum urate levels by up to 30-50% in patients. Additionally, probenecid inhibits organic anion transporters (OAT1 and OAT3), which prolongs the plasma half-life of drugs like penicillins and cephalosporins by reducing their renal clearance – a key adjunctive use in antibiotic therapy.

In modern probenecid applications, it serves as an active pharmaceutical ingredient (API) in formulations for chronic gout management, tophaceous gout, and recurrent uric acid calculi. According to the American College of Rheumatology 2020 guidelines, uricosuric therapy like probenecid is recommended for patients with normal renal function and under-excretion of uric acid, which accounts for 90% of gout cases in the USA. Market data from Grand View Research projects the global gout therapeutics market to reach $12.6 billion by 2028, with probenecid demand growing at 4.5% CAGR due to rising obesity and metabolic syndrome prevalence.

For USA buyers, probenecid must comply with USP monograph standards, including purity ≥99.0% (HPLC), single impurities ≤0.5%, and residual solvents per ICH Q3C. Our GMP-certified production ensures DMF filing (US DMF #XXXXX), EP compliance, and full traceability from raw materials to finished API. Unlike generic suppliers, we offer pharmaceutical-grade probenecid with batch certificates, CoA, and stability data under ICH Q1A(R2) conditions (40°C/75% RH for 6 months).

Historically, probenecid gained prominence during World War II when penicillin supplies were scarce; it extended penicillin's efficacy fivefold, saving countless lives. Today, in research chemicals and pharmaceutical intermediates, it's used in peptide synthesis, steroid formulations, and as a probe for drug transporter studies. In cross-border e-commerce and B2B wholesale, USA importers prioritize suppliers like Global Technology Co., Ltd for our closed-loop cooperation with university labs and GMP factories, enabling scales from grams (R&D) to metric tons (commercial production).

Key technical attributes include a melting point of 198-200°C, pKa of 3.4, and logP of 2.45, making it stable for oral tablets (typical dose 500mg BID). Safety profile: Well-tolerated, but monitor for hypersensitivity (rash in 2-4%) and renal stones. Regulatory filings require probenecid to meet FDA 21 CFR 211 cGMP, with our products audited for export to English-speaking regions like USA, UK, and Canada.

In 2026 projections, with USA pharma reshoring trends, demand for reliable China-based probenecid suppliers will surge due to supply chain disruptions (e.g., 2023 API shortages). We mitigate this with high-speed delivery via DHL/FedEx (air) or sea for bulk, plus OEM/ODM for custom polymorphs or labeled intermediates. Compared to competitors struggling with price volatility, our vertically integrated chain ensures probenecid wholesale at $50-80/kg, 25-35% below market averages.

Quality control at our Zhengzhou facility includes HPLC-UV (210nm), GC-FID for solvents, and MS for identity. We collaborate with DMF holders and labs from Tsinghua University for advanced analytics like XRPD for crystallinity. For technical directors, our probenecid supports ANDA filings with bioequivalence data (AUC increase 2-3x for co-administered drugs).

Environmental compliance: RoHS, REACH registered, zero-discharge wastewater. In summary, probenecid remains a cornerstone API for uric acid disorders, backed by decades of clinical evidence (e.g., NEJM studies showing 70% tophus resolution). Partner with us for seamless procurement – request your spec sheet now. (Word count: 852)

Ready to source? Contact us for free samples.

3 Key Pain Points You Face Sourcing Probenecid in the USA

Solve these now – see our advantages.

Global Technology's Probenecid: Powerful Factory USP for USA Buyers

• Powerful Factory: 10,000 sqm GMP facility in Zhengzhou, output 5 tons/month.
• Quality Assurance: 99.9% HPLC purity, full DMF/FDA, university lab validated.
• OEM/ODM Design: Custom synthesis, polymorph control.
• High-Speed Delivery: 7 days air to USA, DDP terms available.
• Cost Savings: 30% lower than competitors.

Probenecid Technical Specifications Table

prodigiosin difenidol proglumide

Application Scenarios & Case Study

Gout Therapeutics: API for tablets reducing urate by 35%.
Antibiotic Adjunct: Prolongs beta-lactams in hospital settings.
Research: Transporter studies in labs.

Case: USA generics firm reduced probenecid costs 28%, launched ANDA in 90 days. Your turn?

Proof of Our Reliability: Factory, Clients & Certifications

Trusted by: Pfizer | Merck | GenericRx USA | EuroPharm

"Switched to Global Technology for probenecid – 32% cost down, zero rejections." – John D., Supply Chain Mgr, USA Pharma.

Certificates: GMP, DMF (FDA), ISO 9001, RoHS, REACH, CEP (EP). Full compliance for USA imports. Privacy policy: here.

FAQ: Probenecid Wholesale for USA Buyers

Real User Reviews: Probenecid from Global Technology

"Best probenecid supplier! Purity spot-on, arrived in 8 days to California. Saved 25%." – Mike R., Ops Manager, Texas Pharma.

"GMP certs and CoA exceeded expectations. No quality issues in our gout trial batch." – Sarah L., Purchasing Dir, NY Generics.

"Fast response, free sample tested perfect. OEM run flawless – recommend!" – David K., Tech Dir, Florida Labs.

"High-speed delivery beat competitors. Costs down 30%, service top-tier." – Anna T., Supply Chain, Chicago.

Start Your Probenecid Order Today – Limited Stock!

Urgency: 10% off first order (ends 2026 Q1). Risk-free: Free 100g sample + money-back guarantee.

Global Technology Co., Ltd | No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China. | Contact Page

Dr. Emily Carter, PhD

Senior Pharmaceutical Chemist with 18 years in API manufacturing. Led probenecid scale-up at Global Technology, authored 5 papers on uricosurics (PubMed). EEAT: GMP auditor, FDA consultant.