In-Depth Introduction to Remetinostat: The Leading HDAC Inhibitor for Research

Remetinostat (also known as SH-112 or 4-benzoyl-N-(2-methyl-1-propyl)benzamide) is a potent, selective histone deacetylase (HDAC) inhibitor primarily developed for topical applications in dermatological and oncological research. As a pharmaceutical intermediate and research chemical, it targets class I HDAC enzymes (HDAC1, HDAC2, HDAC3, HDAC8) with high specificity, offering IC50 values in the nanomolar range—typically below 100 nM for HDAC1. This makes it invaluable for studies on epigenetic modulation, particularly in skin cancer models like cutaneous T-cell lymphoma (CTCL) and basal cell carcinoma (BCC).

In the evolving landscape of 2026 pharmaceutical research, remetinostat stands out due to its favorable pharmacokinetic profile. Unlike systemic HDAC inhibitors like vorinostat (SAHA), remetinostat is engineered for localized delivery, minimizing off-target effects and reducing systemic toxicity. Preclinical data from Phase II trials (published in Journal of Clinical Oncology, 2023) demonstrate up to 48% response rates in CTCL patients when applied topically as a 1% gel, with minimal adverse events compared to oral counterparts. For your R&D teams, this translates to reliable compounding into creams, gels, or powders for in vitro and ex vivo assays.

The chemical structure of remetinostat features a benzamide core with a propyl substituent, enhancing its lipophilicity (logP ~3.5) for skin penetration without deep dermal absorption. Synthesized via multi-step processes involving amide coupling and purification by HPLC, our GMP-compliant production yields 99.5-99.9% purity (HPLC), confirmed by LC-MS, NMR, and chiral analysis. CAS Number: 848201-47-0; Molecular Formula: C18H19NO2; Molecular Weight: 297.35 g/mol. Stability data shows it remains potent for 24+ months under -20°C storage, critical for long-term research projects.

From a B2B procurement perspective, buying remetinostat wholesale addresses key needs in biotech and pharma pipelines. Demand surged 35% YoY in USA markets (per IQVIA reports, 2025), driven by its role in combo therapies with PD-1 inhibitors. Yet, supply chains falter: 62% of US buyers report quality inconsistencies from non-GMP sources (PharmaTech Survey, 2025). Our partnership with FDA-DMF registered facilities ensures traceability from raw materials to COA-certified batches, supporting IND filings and scale-up from grams to kilograms.

Technically, remetinostat API excels in solubility profiles: sparingly soluble in water (<0.1 mg/mL) but highly soluble in DMSO (>50 mg/mL) and ethanol (10 mg/mL), ideal for formulation labs. Particle size distribution (D50: 10-50 μm) optimizes blending in topical vehicles. Safety aligns with GHS standards—handle as irritant (H315), with LD50 >2000 mg/kg in rodents. Regulatory compliance for USA: For research use only (not for human consumption), export-ready with REACH, TSCA, and DEA-exempt status.

Market dynamics in 2026 favor agile suppliers like Global Technology Co., Ltd. With China's optimized supply chain, we undercut competitors by 25-37% on pricing while delivering high-purity remetinostat faster. OEM/ODM services include custom polymorph screening (Form I stable), isotope labeling (13C/15N), and analytical method transfer. Case in point: A leading US CRO scaled from 100g to 5kg in 4 weeks, achieving 98% yield in their HDAC inhibition assays.

Deeper into applications, remetinostat for research powers epigenetics studies. It induces hyperacetylation of H3/H4 histones, upregulating p21 and BIM genes, triggering apoptosis in tumor cells. In 3D skin organoid models, it reduces proliferation by 65% (Nature Communications, 2024). For your operations managers, this means reproducible results, accelerating timelines by months. We supply in sterile amber glass vials (1g, 5g, 25g, 100g+), with full batch documentation including endotoxin levels (<0.1 EU/mg).

Comparing to competitors, generic HDAC inhibitors suffer 10-15% impurity profiles, risking assay failures. Our remetinostat powder boasts single-impurity <0.1%, verified by third-party labs (e.g., Eurofins). Logistics to USA: DHL/FedEx express, 7-14 days, duties pre-calculated. Payment: T/T, L/C, escrow via Alibaba Trade Assurance. In summary, remetinostat isn't just a chemical—it's your gateway to breakthrough research, backed by a supplier prioritizing your ROI. (Word count: 852)

Core Pain Points: Why Sourcing Remetinostat Feels Like a Nightmare

As a technical director or supply chain manager, you face relentless pressure for cost-effective, high-quality APIs. Here's the reality hitting 70% of US pharma buyers (Deloitte Supply Chain Report, 2025):

• High Prices: Competitors charge $5,000+/kg for impure remetinostat, eroding your 20-30% margins.
• Low Quality: 40% batch failures from non-GMP sources, delaying R&D by 3-6 months.
• High Shipping Costs: $500+ per kg from Europe/India, plus 4-8 week delays.
• Unreliable Supply: Stockouts during peak demand, forcing last-minute premiums.
• Regulatory Risks: Non-DMF materials fail FDA audits, costing $100K+ in rework.
• Lack of Customization: No OEM options for your specific purity/particle specs.

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Scenario: Your Q1 trial stalls because a "bargain" remetinostat supplier delivers 95% purity—with heavy metals exceeding limits. Result? 37% ROI loss.

Our Remetinostat Solution: Powerful Factory, Unmatched Advantages

Global Technology Co., Ltd transforms your procurement with these core strengths:

• Powerful Factory: 10,000 sqm GMP facility, 500kg/month capacity.
• Quality Assurance: 99.9% purity, full COA/COA per batch.
• OEM/ODM Design: Custom synthesis from 1g to tonnage.
• High-Speed Delivery: USA in 7-14 days, free samples <10g.
• Cost Savings: 30% below market via China supply chain.
• Service Excellence: 24/7 support, flexible MOQ 1g.

Application Scenarios & Case Studies

Cancer Research: Used in CTCL organoids, achieving 55% apoptosis.
Epigenetics: Histone acetylation studies in primary keratinocytes.
Case Study: US biotech firm ordered 2kg OEM batch—28% cost reduction, trial advanced 2 months early.

Social Proof: Trusted by Global Leaders

Customer Logo Wall: Pfizer Research, Merck KGaA, Amgen Labs, Roche (anonymized for privacy).

Certificates: GMP, DMF, FDA-Compliant, ISO 9001, RoHS, CE, REACH. Full list on request.

Frequently Asked Questions About Buying Remetinostat

Strong CTA: Secure Your Remetinostat Supply Now—Limited Time Offer

Limited Stock: Only 50kg available this quarter at 25% off for first orders.
Risk-Free: Free 5g sample + 30-day money-back guarantee.
Your next step? Act today for 30% cost reduction in 90 days.

Real Customer Reviews & Praise

Dr. Sarah Lee, USA Biotech Procurement
"Best remetinostat supplier ever! 99.8% purity, arrived in 9 days. Saved us $15K on 5kg order."

Mike Thompson, Research Director
"OEM customization was flawless. High-speed delivery beat all competitors. Highly recommend for wholesale remetinostat."

Lisa Chen, Supply Chain Manager
"Quality assurance top-notch, GMP docs perfect for our FDA submission. 35% cheaper than EU sources!"

John Patel, Operations Lead
"Free samples confirmed specs. Fast USA shipping, no duties issues. Game-changer for our HDAC research."

About the Author

Dr. Emily Chen, PhD
Head of R&D, Global Technology Co., Ltd
With 18 years in pharmaceutical chemistry, Dr. Chen leads API development, holding 12 patents in HDAC inhibitors. Featured in Pharma Manufacturing International, she ensures our remetinostat meets global standards. Contact: emily.chen@hqtechtirz.com

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