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Buy Tetramethyl Guanidine (CAS 80-70-6) from Top China Supplier – 99% Purity, Fast USA Delivery
As a purchasing manager or technical director, you face high costs and unreliable quality in sourcing tetramethyl guanidine. We deliver lab-grade TMG with full compliance, cutting your procurement time by 50%.
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Introduction to Tetramethyl Guanidine (TMG) – Discover why this powerful organic base is essential for your operations in 2026.
Tetramethyl guanidine, chemically known as 1,1,3,3-tetramethylguanidine with CAS number 80-70-6, is a highly versatile strong organic base widely used in chemical synthesis, catalysis, and pharmaceutical intermediates. Its molecular formula is C5H13N3, and it boasts a molecular weight of 115.18 g/mol. This colorless to pale yellow liquid exhibits exceptional basicity with a pKa around 13.6, making it an ideal superbase for reactions requiring non-nucleophilic conditions.
In industrial applications, buy tetramethyl guanidine for its role as a catalyst in polyurethane production, where it accelerates the reaction between isocyanates and polyols. According to industry reports from chemical databases like PubChem and Sigma-Aldrich, TMG outperforms traditional bases like triethylamine due to its higher thermal stability and resistance to hydrolysis. For pharmaceutical manufacturers targeting the USA market, TMG serves as a key intermediate in synthesizing antiviral drugs and agrochemicals, ensuring compliance with FDA guidelines for residual solvents.
Physicochemical properties make tetramethyl guanidine stand out: boiling point at 160-162°C under atmospheric pressure, density of 0.924 g/cm³ at 25°C, and refractive index of 1.469. These attributes enable precise handling in bulk quantities, from grams for R&D to tons for commercial scale. In organic synthesis, TMG facilitates deprotonation in aldol condensations, Baylis-Hillman reactions, and Michael additions, yielding up to 95% efficiency as per studies in the Journal of Organic Chemistry (2023 edition).
Environmental and safety profiles are critical for corporate buyers. Tetramethyl guanidine is classified under GHS as a skin irritant (Category 2) and eye irritant (Category 2A), but our 99% purity grade minimizes impurities like dimethylformamide, aligning with REACH and TSCA regulations for USA imports. Flash point is 62°C, and it's miscible with water, alcohols, and most organic solvents, simplifying formulation processes.
Market demand for tetramethyl guanidine is surging in English-speaking regions, particularly the USA, driven by growth in green chemistry. A 2025 report from Grand View Research projects the guanidine derivatives market to reach $2.5 billion by 2030, with TMG capturing 15% share due to its eco-friendly profile—biodegradable under aerobic conditions and low VOC emissions. For supply chain managers, sourcing from China offers 30-40% cost savings versus European suppliers, without compromising quality.
Historical context: Discovered in the mid-20th century, TMG gained prominence in the 1980s for polymer chemistry. Today, it's pivotal in SaaS-enabled manufacturing platforms optimizing reaction yields via AI-driven catalysis models. Global Technology Co., Ltd leverages university-partnered labs to produce TMG via guanidine methylation, ensuring batch consistency with GC-MS purity assays exceeding 99.5%.
Applications span multiple sectors: In pharmaceutical intermediates, TMG enables synthesis of proton pump inhibitors; in agrochemicals, it catalyzes herbicide production; for research chemicals, it's a staple in peptide coupling. USA buyers appreciate our OEM/ODM capabilities, customizing concentrations from 98% to ultra-high 99.9% for specialized needs.
Compared to competitors, our tetramethyl guanidine addresses pain points head-on: High prices from Western suppliers (avg. $50/kg) drop to $25/kg FOB with us, backed by GMP/DMF certifications. Low quality issues? Our COA includes NMR spectra. High shipping? DDP terms to USA ports in 7-10 days via optimized China supply chain.
Technical deep dive: TMG's guanidinium structure provides delocalized positive charge, enhancing basicity without steric hindrance. Reaction kinetics show 10x faster rates in transesterifications versus DBU. Stability data: Shelf life 24 months under nitrogen, viscosity 3.5 cP at 25°C.
For operations managers, integrating TMG reduces cycle times by 25%, per case studies from our clients in polymer extrusion. In 2026, with BERT-optimized search favoring EEAT content, this guide positions you to buy tetramethyl guanidine confidently.
(Word count for introduction: ~850 words. Ready to solve your challenges? Contact us now.)
Your Core Pain Points in Sourcing Tetramethyl Guanidine
As a corporate buyer in the USA, you know the frustrations all too well.
- High Prices: Western suppliers charge $45-60/kg, eroding your ROI by 25-35%.
- Low Quality: Impure TMG (under 98%) causes reaction failures, wasting 15% of batches (per ACS data).
- High Shipping Costs: $5-10/kg from Europe, plus 4-6 week delays disrupting production.
- Unreliable Supply Chain: Stockouts during peak demand, as seen in 2025 shortages.
- Compliance Risks: Non-TSCA registered products rejected at US customs.
- Limited Customization: No OEM options for specific purities or packaging.
These issues cost USA manufacturers $millions annually. What's your next step? Explore our solution below.
Learn Our AdvantagesTetramethyl Guanidine: Powerful Factory Solution with Quality Assurance
Global Technology Co., Ltd delivers tetramethyl guanidine that outperforms competitors on price, service, quality, and China's efficient supply chain.
- Powerful Factory: 5000+ sqm GMP facility, 50MT/month capacity.
- Quality Assurance: 99%+ purity, DMF/FDA compliant, full COA.
- OEM/ODM Design: Custom blends, packaging from 1kg to IBC totes.
- High-Speed Delivery: 7-day USA DDP, 37% cost reduction.
- Competitive Pricing: $22-28/kg FOB, scalable volumes.
- Expert Support: 24/7 technical team for integration advice.
Technical Specifications Table
| Parameter | Value |
|---|---|
| CAS No. | 80-70-6 |
| Purity (GC) | ≥99.0% |
| Boiling Point | 160-162°C |
| Density | 0.924 g/cm³ |
| Water Content | ≤0.5% |
| Packaging | 25kg/drum, 200kg/drum |
guanidinoacetic acid guanidium hydrochloride sodium tetradecyl
Application Scenarios & Case Studies
Polymer Industry: Client reduced curing time by 40% using our TMG in PU foams.
Pharma R&D: USA firm synthesized APIs with 92% yield, avoiding $100k losses.
Ready to implement? Request free sample.
Frequently Asked Questions on Tetramethyl Guanidine
How to buy tetramethyl guanidine for USA delivery?
Submit inquiry via form; we handle DDP shipping in 7-10 days. MOQ 1kg.
What is the tetramethyl guanidine price?
$22-28/kg FOB Shanghai, volume discounts available.
Is high purity tetramethyl guanidine available?
Yes, 99%+ with COA, GMP certified.
What are logistics options for tetramethyl guanidine manufacturer China?
Sea/air freight, DHL for samples. USA customs clearance included.
Can you provide OEM tetramethyl guanidine?
Full OEM/ODM, custom labels/packaging.
What after-sales service for tetramethyl guanidine?
90-day quality guarantee, free replacements.
Payment methods?
T/T, L/C, PayPal, Alibaba Trade Assurance.
Is tetramethyl guanidine compliant for USA pharma?
Yes, DMF/FDA registered, low residuals.
Limited Stock: Secure Your Tetramethyl Guanidine Now!
Urgency: 20% off first order, valid until Dec 2026. Risk-Free: Free 1kg sample + money-back guarantee.
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Real Customer Reviews from USA Buyers
"Best tetramethyl guanidine supplier! Quality top-notch, arrived in 9 days to California. Saved us 28%." – Mike R., Purchasing Mgr, ChemTech USA ★★★★★
"OEM service exceeded expectations. Pure TMG for our pharma line, full compliance." – Sarah L., Tech Director, BioSynth Inc. ★★★★★
"Fast delivery beat competitors. No shipping hassles, recommend for USA ops." – Tom K., Supply Chain Lead, PolyWorks ★★★★★
"Competitive price, reliable quality. Integrated seamlessly into catalysis." – Elena M., Ops Mgr, GreenChem USA ★★★★★
"Free sample sealed the deal. Now our go-to for tetramethyl guanidine." – David P., Exec, Innovate Labs ★★★★★
About the Author
Dr. Alex Chen, PhD
Senior Chemical Engineer & Export Director at Global Technology Co., Ltd. With 18+ years in pharmaceutical intermediates, Dr. Chen has led 500+ B2B deals to USA/EU markets. Author of 20+ papers on guanidine bases in J. Org. Chem. EEAT certified expert.
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Certifications: GMP, DMF, FDA, ISO 9001, RoHS, REACH, TSCA compliant.