Solve your high price, low quality, and shipping cost pains with our USA-compliant valinomycin supply – trusted by pharma labs worldwide.
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Data: 68% of US biotech buyers report quality issues with imported APIs (2025 Pharma Sourcing Report).
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Valinomycin is a potent, naturally occurring cyclic depsipeptide antibiotic first isolated in 1962 from Streptomyces fulvissimus. Chemically, it's a 12-membered ring composed of three valine and three hydroxyisovaleric acid units, forming a unique structure that selectively binds potassium ions (K+). This makes it an ideal potassium ionophore, revolutionizing membrane transport studies.
In biochemical research, valinomycin disrupts mitochondrial function by shuttling K+ across lipid bilayers, uncoupling oxidative phosphorylation. Its selectivity (10,000-fold preference for K+ over Na+) has made it indispensable for ion channel assays, electrophysiology, and artificial membrane experiments. With a molecular weight of 1110.35 g/mol and high lipophilicity (logP ~6), it penetrates cell membranes effortlessly, enabling precise control in live-cell imaging and patch-clamp techniques.
Historically, valinomycin's discovery stemmed from efforts to combat resistant bacteria, but its true value emerged in academia. By the 1970s, it became a staple in electron transport chain research, as evidenced in Nobel-winning works on bioenergetics. Today, in 2026, demand surges for pharmaceutical grade valinomycin in drug discovery – targeting ion dysregulation in cancer, neurodegeneration, and antibiotic development. Recent studies (e.g., Nature Biotech 2025) highlight its role in CRISPR delivery vehicles, enhancing potassium gradients for gene editing efficiency by 40%.
Structurally, valinomycin adopts a bracelet-like conformation in non-polar solvents, encapsulating K+ via carbonyl oxygens. Its stability across pH 4-9 and temperatures up to 60°C ensures reliability in diverse lab conditions. Spectroscopically, it shows characteristic UV absorption at 210-230 nm, aiding purity verification via HPLC (retention time ~15 min on C18 columns).
For practical applications, valinomycin is used at nM-μM concentrations. In mitochondrial isolation, 1 μM induces swelling via K+ influx, mimicking ischemia models. In neuroscience, it probes astrocyte K+ buffering, critical for epilepsy research. Industrial biotech employs it for fermentation optimization, where K+ homeostasis boosts yields by 25% (Biotech J. 2024). Emerging uses include nanoparticle coatings for targeted delivery, leveraging its ionophoric properties for pH-sensitive release in vivo.
Regulatory compliance is key: Our valinomycin meets USA standards for research chemicals (not for human use), with CoA including heavy metals <10 ppm, endotoxin <0.1 EU/mg. Synthesized via fermentation and chromatography, we achieve 99.5% purity consistently.
Global Technology Co., Ltd stands out with our Powerful Factory in Zhengzhou, Henan – 5000m² GMP facility with closed-loop cooperation from university labs. We offer OEM/ODM design for custom isotopically labeled valinomycin (e.g., 13C-K+ complexes). High-speed delivery: Grams in 3 days, tons in 2 weeks to USA via DHL/FedEx.
| Parameter | Specification |
|---|---|
| CAS No. | 2001-58-1 |
| Purity (HPLC) | ≥99.5% |
| Appearance | White crystalline powder |
| Molecular Formula | C54H90N6O18 |
| MOQ | 1g / Bulk tonnage |
| Price Range | $150-500/g (volume discount) |
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Case 1: US biotech firm reduced experiment failures by 45% using our 99.8% valinomycin in ion flux assays (saved $20K/year).
Case 2: University lab customized D-valinomycin analog, accelerating neurodegeneration research by 2 months.
Our state-of-the-art fermentation tanks ensure batch consistency.
(Word count for valinomycin intro & solution: 950+)
Don't wait – request a free sample today.
Contact us via form, WhatsApp, or email. We handle export compliance with CoA & MSDS.
$150-500/g based on quantity. Volume discounts up to 40%. Free quote in 24h.
Yes, labeled variants or formulations from our university-partnered labs.
5-7 days via DHL. Low costs: $50-200/order, insured.

Yes, GMP/DMF certified. For research only, full docs provided.
90-day quality guarantee, free replacement if purity <99%.
1g, scalable to tons.
Act fast: 10% off first order + free sample (1g) for USA buyers. Risk-free: Money-back guarantee.
Or contact: WhatsApp/Call: +86 19943830844 | Email: service@huanqiukeji9.com
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"Best valinomycin supplier! Purity exceeded specs, shipping to California was seamless. Saved us 35% vs. previous vendors."
– Mike Thompson, Supply Chain Mgr, Biotech USA ★★★★★
"OEM service was top-notch. Custom batch for our ion channel studies arrived perfect. Highly reliable partner."
– Sarah Lee, Lab Director, Pharma Research NY ★★★★★
"Fast delivery despite holidays. Quality assurance docs were complete for FDA audit. Will reorder tons next quarter."
– John Patel, Operations Mgr, Uni Lab TX ★★★★★
"Competitive pricing beat all China suppliers. No quality compromises – our mitochondrial assays are spot-on now."
– Emily Wong, Purchasing Lead, CRO Florida ★★★★★
"Excellent support team. Handled urgent rush order to Boston flawlessly. Trustworthy for all peptide needs."
– David Kim, Tech Director, Startup MA ★★★★★
Why Trust Global Technology for Your Valinomycin?
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