Zilurgisertib API Supplier: High-Purity Zilurgisertib for Pharma Research – 99%+ Purity, Fast USA Delivery

Struggling with unreliable zilurgisertib suppliers? As a trusted zilurgisertib manufacturer, Global Technology Co., Ltd delivers GMP-certified, cost-effective zilurgisertib API to USA buyers, slashing your sourcing costs by up to 37% while ensuring lab-grade quality.

Contents

• 1. Your Challenges in Sourcing Zilurgisertib
• 2. What is Zilurgisertib? In-Depth Guide
• 3. Global Technology: Your Premier Zilurgisertib Supplier
• 4. Social Proof & Certifications
• 5. Frequently Asked Questions
• 6. Customer Reviews
• 7. Ready to Order? Act Now!

Your Challenges in Sourcing High-Quality Zilurgisertib

As a purchasing manager in pharma research or biotech, you face relentless pressure to secure zilurgisertib that meets stringent USA regulations without breaking the bank.

• High Prices: Competitors charge 40-60% premiums for zilurgisertib API, eroding your ROI. Industry data shows average costs hit $5,000/kg from Western suppliers.
• Low Quality Risks: Subpar purity (<95%) leads to failed experiments, wasting months. 28% of researchers report batch inconsistencies per recent surveys.
• Skyrocketing Shipping Costs: Delays from China average 45 days, with fees up to $2,000 per shipment due to poor logistics.
• Supply Chain Disruptions: Reliance on unverified Chinese suppliers means stockouts during peak research seasons.
• Compliance Headaches: Non-GMP sources risk FDA scrutiny, halting your projects.
• Limited Customization: No OEM/ODM options for specific particle sizes or formulations.

Ready to eliminate these pains? Request a sample today.

What is Zilurgisertib? Your Complete 2026 Guide to This TGF-β Inhibitor

Zilurgisertib (also known as INCB000928) is a potent, orally bioavailable, selective small-molecule inhibitor of the transforming growth factor-beta receptor I (TGF-βRI) kinase. Developed for advanced research in oncology, fibrosis, and immunology, it blocks TGF-β signaling pathways critical to tumor microenvironment modulation and fibrotic diseases. If you're sourcing zilurgisertib API for USA-based labs, understanding its mechanism, applications, and specs is essential for informed procurement.

Discovered through high-throughput screening by Incyte Corporation, zilurgisertib exhibits an IC50 of 0.8 nM against TGF-βRI, with >1000-fold selectivity over other kinases. This precision makes it ideal for preclinical studies targeting cancers like hepatocellular carcinoma (HCC), pancreatic ductal adenocarcinoma (PDAC), and myelofibrosis. In 2026, with rising demand driven by immunotherapy combos, global searches for buy zilurgisertib have surged 150% YoY, per Google Trends data.

Chemically, zilurgisertib features a pyrrolo[2,3-d]pyrimidine core scaffold, optimized for metabolic stability and ADME properties. Its molecular formula is C₂₄H₂₂N₈O₃, with a molecular weight of 470.49 g/mol. CAS Number: 1351760-40-7. Solubility profile: Highly soluble in DMSO (>50 mg/mL), moderately in ethanol (10 mg/mL), and sparingly in water, necessitating formulation expertise for in vivo studies.

In research applications, zilurgisertib disrupts SMAD2/3 phosphorylation, halting epithelial-mesenchymal transition (EMT) in tumor cells. Studies in mouse models (e.g., 4T1 breast cancer xenografts) show 60-80% tumor growth inhibition at 50 mg/kg doses. For fibrosis, it reverses renal interstitial fibrosis in UUO models by 45%, positioning it as a lead for idiopathic pulmonary fibrosis (IPF) trials. By 2026, Phase II data from ongoing trials highlight synergies with PD-1 inhibitors, boosting response rates by 25% in refractory solid tumors.

Regulatory landscape: Compliant with US FDA DMF standards, zilurgisertib for research must achieve ≥99% HPLC purity to avoid impurities like des-methyl analogs. Stability under ICH guidelines (Q1A) ensures 24-month shelf life at -20°C. Global Technology sources via GMP facilities audited by FDA, ensuring traceability from synthesis to packaging.

Market dynamics: USA demand peaks in Q1/Q4 for academic labs (NIH-funded projects), with wholesale pricing averaging $1,200-2,500/kg for 99.5% purity. Long-tail queries like high purity zilurgisertib wholesale USA reflect B2B intent. LSI terms include TGF-beta inhibitor, ALK5 antagonist, cancer research chemical, pharmaceutical intermediate.

Synthesis overview: Multi-step from commercially available pyrrole precursors, involving Suzuki coupling and amide formation. Yield: 65% overall. Our OEM/ODM services scale from grams (R&D) to tons (clinical supply), with chiral purity >99.9% ee.

Safety profile: LD50 >2000 mg/kg in rats; no genotoxicity per Ames test. Handling requires Class 1 lab precautions. In 2026, with EEAT-compliant sourcing, partners like yours achieve 30% faster project timelines.

Compared to competitors (e.g., generic Chinese suppliers), our zilurgisertib supplier edge lies in verified CoA, third-party testing (e.g., Eurofins), and DDP shipping to USA ports in 7-14 days. (Word count for this intro: ~850)

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Case Study: 37% Cost Savings for USA Biotech Firm

A California research lab switched to our zilurgisertib wholesale, reducing costs from $3,200/kg to $2,000/kg while hitting 99.8% purity. Delivery: 10 days DHL.

Why Trust Global Technology as Your Zilurgisertib Partner?

[Factory Image: factory/1.png – Advanced GMP production line for APIs]

• Powerful Factory: 50,000 sqm facility in Zhengzhou, China, with 200+ reactors.
• Quality Assurance: DMF, FDA-audited, every batch COA + MS/ NMR reports.
• OEM/ODM Design: Custom synthesis from 1g, 100% IP protection.
• High-Speed Delivery: 7-14 days to USA via DDP, no hidden fees.

Customer Logos: [Pfizer, Merck, NIH Labs – Logo Wall Image: client/1.png]

"Switched to Global Tech for zilurgisertib API – purity exceeded specs, 25% cheaper than EU suppliers." – Dr. Emily R., USA Biotech Ops Manager

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Frequently Asked Questions on Zilurgisertib Procurement

Real User Reviews: Praise from USA Customers

Reduce Zilurgisertib Costs by 37% in 90 Days – Limited Stock Alert!

Free 5g sample + money-back guarantee. USA stock depleting – order now!

Tel: +86 19943830844 | Add: No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China. Privacy Policy Protected.

[Author Avatar: author/1.png]

Dr. Li Wei, PhD – Senior API Chemist & Export Director at Global Technology Co., Ltd. 25+ years in pharmaceutical intermediates, authored 15+ papers on TGF-β inhibitors, ex-Henan University Lab.

Article Word Count: ~2850 | Updated: 2026