4-Methyl-2-oxopentanoic acid CAS NO.816-66-0

4-Methyl-2-oxopentanoic acid CAS NO.816-66-0

4-Methyl-2-oxopentanoic acid CAS NO.816-66-0

4-Methyl-2-oxopentanoic acid CAS NO.816-66-0

4-Methyl-2-oxopentanoic acid CAS NO.816-66-0

4-Methyl-2-oxopentanoic acid, widely recognized in the market as α-Ketoisocaproic acid (KIC) or ketoleucine, is a pivotal endogenous metabolite derived from the transamination of the essential branched-chain amino acid L-Leucine. This high-purity alpha-keto acid serves as a direct precursor in leucine metabolism, strategically positioned to support energy production and nitrogen management. It is particularly valued in nutritional science for its ability to promote an anabolic state while reducing muscle protein breakdown, making it a key ingredient for athletes seeking efficient recovery and muscle growth support without the burden of additional nitrogen excretion.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
4-Methyl-2-oxopentanoic acid
CAS NO.
816-66-0
Appearance
White to off-white crystalline powder
Molecular Formula
C6H10O3
Molecular Weight
130.14 g/mol
Purity (RP-HPLC)
≥ 98.0%
Solubility
Soluble in water; slightly soluble in ethanol; insoluble in non-polar solvents
Endotoxin< 0.1 EU/mg
Biological Activity
Precursor to L-leucine; supports branched-chain amino acid metabolism and muscle protein synthesis
Storage Conditions
Store at 2–8°C, protected from light and moisture
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

The compound exerts its effects through a multi-faceted mechanism: it is rapidly converted back to L-Leucine in the body, thereby directly activating the mTOR signaling pathway to stimulate muscle protein synthesis. Concurrently, it exhibits anticatabolic properties by inhibiting the degradation of skeletal muscle proteins. At the metabolic level, it functions as an oxidative phosphorylation (OXPHOS) inhibitor and an uncoupler by targeting the alpha-ketoglutarate dehydrogenase complex (OGDC), which influences energy metabolism and mitochondrial function. This dual action of promoting synthesis while reducing breakdown makes it a potent modulator of net protein balance.

upload/attachment/image/202604/08/1775626659d7336d0661056124ba6c9ee9d69f3baa_local.png

2.PRODUCT INDICATIONS

This product is primarily indicated for use in dietary supplements targeting muscle performance and recovery, appealing to athletes, bodybuilders, and individuals engaged in intensive training. Beyond sports nutrition, it holds significant relevance in clinical research applications, including metabolic disorder studies such as maple syrup urine disease (MSUD) due to its role in branched-chain amino acid metabolism. Additionally, its nitrogen-sparing properties make it a candidate for investigation in renal nutrition strategies, particularly in formulations aimed at managing muscle wasting associated with chronic kidney disease or acute renal dysfunction.

upload/attachment/image/202604/08/17756266868909764765fbccd5aa13df418d3f0189_local.png

3.CLINICAL EFFICACY OF PRODUCT

Research and clinical observations have demonstrated that supplementation with 4-Methyl-2-oxopentanoic acid effectively elevates plasma leucine levels, which is directly correlated with enhanced rates of muscle protein synthesis. Studies indicate its efficacy in shifting the body from a catabolic to an anabolic state, thereby aiding in the preservation of lean body mass during periods of stress or caloric restriction. In athletic populations, it has been shown to accelerate post-exercise recovery and reduce markers of muscle damage. Its clinical utility is further supported by its role in improving nitrogen balance in patients with renal impairment, offering a therapeutic approach to combat muscle atrophy.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.


Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

upload/attachment/image/202603/11/17731937213fbed5ed3f3869d1613bb629f6365f21_local.png


5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

upload/attachment/image/202601/20/1768872924be74a0641f7ddbf20e541c97f2066c5c_local.jpg


Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.


We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


HotTags:KIC, AlphaKetoisocaproate, LeucineMetabolite, MuscleRecovery, Anabolic, BCAAMetabolism, NitrogenSparing, BodybuildingSupplement, ResearchChemical, MetabolicHealth, Supplier, Manufacturer, Bulk order,  Pharmaceutical.


If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553

Premium API Oxandrolone Ucinky Manufacturing
May 25, 26
Premium API Oxandrolone Ucinky Manufacturing
Premium API Oxandrolone Ucinky Manufacturing Leading global supplier of high-purity chemical raw materials for pharmaceutical grade Oxandrolone Ucinky, combining precision engineering with industrial scale. 5000 kg Annual Output 120 Countries Served 5 Days Sample Lead Time 99.7 On-Time Delivery Industrial Precision Pure Chemical Synthesis Engineering the future of pharmaceutical intermediates with unmatched stability. Our facility stands as a global leader in the oxandrolone ucinky sector, utilizing CRYOGENIC CRYSTALLIZATION and advanced chromatography to ensure an assay purity exceeding 99.8. We integrate a fully automated closed-loop system that eliminates human error and contamination.
Clinical Benefits and Applications of Oxandrolone Therapy
May 22, 26
Clinical Benefits and Applications of Oxandrolone Therapy
Oxandrolone therapy represents a sophisticated intersection of endocrine science and regenerative medicine, primarily utilized to address muscle wasting and metabolic dysfunction. In the global pharmaceutical landscape, this specific approach to androgen therapy is valued for its unique ability to promote protein synthesis while exhibiting a lower androgenic profile compared to traditional steroids, making it a critical tool for patients recovering from severe trauma or chronic illness. From a clinical perspective, understanding the nuances of oxandrolone therapy is essential for optimizing patient outcomes in weight gain and tissue repair.
Clinical Benefits and Production of Oxandrolone Steroid
May 20, 26
Clinical Benefits and Production of Oxandrolone Steroid
The global pharmaceutical landscape has seen a significant rise in the demand for highly specialized anabolic agents, among which the oxandrolone steroid stands out due to its unique chemical profile and therapeutic versatility. As a modified version of dihydrotestosterone, this compound provides a potent means of addressing muscle wasting and metabolic deficits, making it a critical asset in both clinical rehabilitation and advanced physiological research. Understanding the nuances of this synthetic compound is essential for healthcare providers and researchers alike, as it balances efficacy with a relatively lower androgenic profile compared to other steroids.

If you are interested in our products, you can choose to leave your information here, and we will be in touch with you shortly.