Name: 7-Acetyltaxol CAS 92950-39-5 - Effective Anticancer Agent
Availability: InStock
Rating: 4.5 (89 reviews)

7-Acetyltaxol CAS NO.92950-39-5

7-Acetyltaxol is a semi-synthetic derivative of paclitaxel, characterized as a white to off-white solid powder primarily utilized as a high-purity reference standard, impurity profiling marker (often identified as Paclitaxel EP Impurity L), and a vital tool for early-stage pharmacological research in oncology. This stable taxane analog features an acetyl group modification at the C-7 position, making it indispensable for researchers conducting structure-activity relationship (SAR) studies, analytical method validation, and the qualitative analysis of paclitaxel-based drug substances. It is specifically catered to pharmaceutical R&D scientists, quality control laboratories, and academic institutions requiring reliable chemical references to ensure drug safety, purity, and compliance with international pharmacopeial standards.

consult@huanqiukeji9.com

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	7-Acetyltaxol
CAS NO.	92950-39-5
Appearance	White to off-white amorphous powder
Molecular Formula	C49H53NO15
Molecular Weight	895.94 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in DMSO, Chloroform, Ethyl Acetate; insoluble in water
Endotoxin	≤ 5 EU/mg
Biological Activity	Semi-synthetic taxane derivative; acts as a microtubule stabilizer and potent anticancer agent (mitotic inhibitor).
Storage Conditions	Store at -20°C, protected from light and moisture. Keep container tightly sealed.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This compound exerts its biological activity by binding specifically to the N-terminal region of the beta-tubulin subunit within microtubules, which facilitates the assembly of tubulin dimers and critically stabilizes the polymerized microtubule network against depolymerization. By locking microtubules in a stabilized state, 7-Acetyltaxol disrupts the normal dynamic instability required for microtubule function, effectively preventing the proper formation of the mitotic spindle apparatus during cell division. Consequently, this interference halts the cell cycle at the G2/M transition phase, inhibiting chromosomal segregation and ultimately triggering cell cycle arrest and apoptosis in rapidly dividing cells, a mechanism shared with its parent compound, paclitaxel.

upload/attachment/image/202605/12/1778556007263427c86ce99f71af4324e03ba451fc_local.png

upload/attachment/image/202605/12/177855658724299f79590cf98af7fcb1cf8e0a8b30_local.png

2.PRODUCT INDICATIONS

7-Acetyltaxol is indicated strictly for non-clinical, in vitro research applications, including its use as a certified reference material for the identification and quantification of related substances in paclitaxel active pharmaceutical ingredients (APIs). It is widely employed by analytical chemists and pharmaceutical developers for method development in High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to detect and control impurity profiles in taxane manufacturing processes. Additionally, it serves cellular biologists and oncological researchers investigating microtubule dynamics, tubulin binding interactions, and cytotoxic resistance mechanisms, providing a crucial benchmark for comparing the bioactivity of novel taxane derivatives.

upload/attachment/image/202605/09/1778314663d59b7b7389f862bcf6d517b1cffc661a_local.png

3.CLINICAL EFFICACY OF PRODUCT

In rigorous preclinical research settings, 7-Acetyltaxol has demonstrated biological efficacy comparable to paclitaxel regarding the promotion of microtubule assembly and the inhibition of cellular replication in various murine and human cell lines, including macrophage-like J774.2 cells. Experimental data indicates that the acetylation at the C-7 hydroxyl group does not abolish the core cytotoxic potential nor the ability to induce microtubule polymerization, affirming that this specific position is tolerant to modification without sacrificing primary bioactivity. These findings establish its utility in proving that the C-7 site is available for structural optimization in drug design, while its consistent performance in cytotoxicity assays (with reported IC50 values around 60 nM in specific models) validates its role as a standard for bioactivity benchmarking.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

upload/attachment/image/202603/30/17748488791d02f82103a700e61eeafa024a96f6ff_local.jpg

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

upload/attachment/image/202601/20/1768872924be74a0641f7ddbf20e541c97f2066c5c_local.jpg

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: 7-Acetyltaxol, 7-Acetyl Paclitaxel, Paclitaxel Impurity L, Taxane Derivative, EP Reference Standard, Microtubule Stabilizer, Anticancer Research, Pharmaceutical Intermediate, Cytotoxic Agent, Analytical Standard

If you have any product requirements, please send an email to:consult@huanqiukeji9.com