Bromodiphenhydramine hydrochloride CAS NO.1808-12-4
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Bromodiphenhydramine hydrochloride |
| CAS NO. | 1808-12-4 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C17H20BrNO·ClH |
| Molecular Weight | 264.36g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in Water, Methanol, Ethanol, DMSO; insoluble in Ether, Chloroform |
| Endotoxin | < 10 EU/mg |
| Biological Activity | First-generation antihistamine (H1 receptor antagonist); sedative and anticholinergic properties; commonly used as a research chemical for allergy and sleep studies. |
| Storage Conditions | Store at 2-8°C or room temperature, protected from light. Keep container tightly sealed. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Bromodiphenhydramine hydrochloride exerts its therapeutic effects by competitively antagonizing histamine at H1-receptor sites throughout the body, effectively blocking the binding of endogenous histamine to prevent the cascade of allergic symptoms such as vasodilation, increased capillary permeability, and bronchoconstriction. Beyond its primary antihistaminic action, the compound exhibits significant antimuscarinic activity by blocking acetylcholine receptors, which contributes to its efficacy in treating extrapyramidal symptoms and provides the central nervous system sedation observed in most patients. This dual mechanism allows it to inhibit the negative physiological responses induced by histamine, including pruritus and smooth muscle spasm, while its enhanced lipid solubility compared to diphenhydramine facilitates greater penetration of the blood-brain barrier, resulting in its characteristic sedative and antiemetic properties.
2.PRODUCT INDICATIONS
Bromodiphenhydramine hydrochloride is indicated for non-clinical research and pharmaceutical development applications focusing on allergic diseases, where it is utilized to evaluate the efficacy of novel anti-allergic agents and study the pathophysiology of histamine-mediated reactions. Researchers employ this compound to investigate cutaneous allergy models, motion sickness pathways, and the potential for drug-induced extrapyramidal side effects, often using it as a benchmark for comparing the sedative profiles of ethanolamine-class antihistamines. Furthermore, it serves as a primary pharmaceutical intermediate and analytical standard for manufacturers developing over-the-counter allergy medications, catering to professionals in drug discovery, toxicology screening, and the formulation of antihistamines for conditions ranging from urticaria to mild Parkinsonian symptoms.
3.CLINICAL EFFICACY OF PRODUCT
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
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Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
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Professional and Secure Packaging
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We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
HotTags:Bromodiphenhydramine Hydrochloride, Antihistamine, H1 Receptor Antagonist, Ethanolamine, Anticholinergic, Sedative, Allergy Research, Ambodryl, Bromazine, Cutaneous Allergy, Motion Sickness, Pharmaceutical Intermediate, Research Standard, Antimicrobial
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