Name: Citropten CAS 487-06-9: Natural Citrus Extract Benefits
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Citropten CAS NO.487-06-9

Citropten, also known as 5,7-Dimethoxycoumarin or Limettin, is a naturally occurring coumarin derivative primarily isolated from citrus fruits such as bergamot, lime, and bitter orange. It is widely utilized as a high-purity reference standard in phytochemical analysis and pharmacological research due to its multifaceted bioactivities, including anti-inflammatory, anticancer, and neuroprotective properties. This compound is particularly valued in the development of nutraceuticals, functional foods, and cosmetic formulations targeting skin health and inflammatory conditions.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Citropten
CAS NO.	487-06-9
Appearance	White to off-white crystalline powder
Molecular Formula	C₁₁H₁₀O₄
Molecular Weight	206.19 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in ethanol, DMSO, and methanol; slightly soluble in water; insoluble in non-polar solvents (e.g., hexane, chloroform)
Endotoxin	≤ 5 EU/mg (for cell culture grade)
Biological Activity	Antioxidant, anti-inflammatory (via NF-κB and MAPK inhibition), anti-cancer (induces apoptosis in tumor cells), MAO-A/AChE inhibitor (neuroprotective), enhances skin barrier function, modulates neurotransmitter systems
Storage Conditions	Store at 2–8°C, protected from light and moisture; stable for 24 months under recommended conditions
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Citropten exerts its biological effects through multiple signaling pathways. It inhibits the activation of NF-κB and MAPK cascades, reducing the production of pro-inflammatory cytokines like TNF-α and IL-6. The compound also modulates neurotransmitter systems by inhibiting monoamine oxidase A (MAO-A) and acetylcholinesterase (AChE), thereby enhancing monoaminergic neurotransmission. Additionally, it induces cell cycle arrest at the G1 phase and promotes melanogenesis in melanoma cells via ERK pathway modulation, while also exhibiting antimicrobial activity against Helicobacter pylori through urease inhibition.

2.PRODUCT INDICATIONS

This compound is indicated for research in inflammatory and autoimmune conditions, such as colitis and arthritis, leveraging its NF-κB inhibitory activity. It is also employed in dermatological studies for skin whitening, photoprotection, and melanoma differentiation therapy. Furthermore, Citropten is used in neuropharmacology research for depression and cognitive disorders, as well as in gastroenterology for anti-Helicobacter pylori applications, targeting researchers in natural product development and drug discovery.

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3.CLINICAL EFFICACY OF PRODUCT

Preclinical studies demonstrate that Citropten significantly alleviates dextran sulfate sodium (DSS)-induced colitis in mice, improving body weight loss and histological scores. It exhibits potent anti-melanoma activity by inducing differentiation and cell cycle arrest in human melanoma cell lines. In rodent models of chronic mild stress, it shows antidepressant-like effects by upregulating heat shock protein-70 and inhibiting MAO-A. While human clinical data are limited, its favorable pharmacokinetic profile supports its potential as a lead compound

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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