Name: Coclaurine CAS 486-39-5: High-Purity Natural Compound
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Coclaurine CAS NO.486-39-5

Coclaurine, also known as "Linderaline" or "Coclaurine alkaloid," is a naturally occurring benzylisoquinoline alkaloid primarily extracted from traditional medicinal plants such as Lindera aggregata(Chinese Spicebush) and Sarcopetalum harveyanum. It serves as a key intermediate in the biosynthesis of various isoquinoline alkaloids and is widely utilized as a high-purity reference standard in phytochemical analysis and pharmacological research. This compound is particularly valued for its dual cardiovascular and neurological activities, making it a critical raw material for drug discovery and natural product development targeting hypertension, cancer, and neuroprotection.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Coclaurine
CAS NO.	486-39-5
Appearance	White to off-white crystalline powder
Molecular Formula	C₁₇H₁₉NO₃
Molecular Weight	285.34 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in methanol, ethanol, DMSO; sparingly soluble in water; insoluble in non-polar solvents (e.g., hexane)
Endotoxin	≤ 5 EU/mg (for cell culture grade)
Biological Activity	Acts as a non-selective antagonist of nicotinic acetylcholine receptors (nAChRs), modulates dopaminergic and cholinergic neurotransmission, exhibits hypotensive and vasodilatory effects, potential anti-cancer and anti-inflammatory activities via inhibition of cell proliferation and cytokine modulation
Storage Conditions	Store at -20°C, protected from light and moisture; stable for 24 months under recommended conditions
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Coclaurine exerts its biological effects through multiple pathways, primarily acting as a non-selective antagonist of nicotinic acetylcholine receptors (nAChRs), which modulates cholinergic and dopaminergic neurotransmission in the central nervous system. Additionally, it functions as a calcium channel blocker, inhibiting extracellular calcium influx into vascular smooth muscle cells, thereby inducing vasodilation and reducing blood pressure. In oncology research, Coclaurine has been shown to downregulate EFHD2-associated NOX4-ABCC1 signaling, disrupt the FOXG1-EFHD2 promoter interaction, and reverse cisplatin resistance in non-small cell lung cancer (NSCLC) cells by suppressing cancer stemness and metastatic properties.

2.PRODUCT INDICATIONS

This compound is indicated for research in cardiovascular diseases, including hypertension, angina, and arrhythmia, due to its vasorelaxant and negative chronotropic effects. It is also employed in neuropharmacology studies for investigating neurodegenerative disorders, addiction, and depression, leveraging its nAChR antagonism and dopaminergic modulation. Furthermore, Coclaurine is used in cancer research to enhance chemotherapy sensitivity and inhibit tumor metastasis, targeting researchers in phytopharmacology, oncology, and natural product synthesis.

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3.CLINICAL EFFICACY OF PRODUCT

Preclinical studies demonstrate that Coclaurine significantly reduces mean arterial pressure and heart rate in animal models, with efficacy comparable to verapamil in relaxing pre-contracted aortic rings. In cancer models, it enhances the cytotoxicity of cisplatin and suppresses the stemness and invasive capacity of NSCLC cells. Although clinical data in humans are limited, its high bioavailability and low toxicity profile in vitro and in vivo support its potential as a lead compound for developing novel therapeutics.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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