![[D-Leu2]-Melanocyte-Stimulating Hormone-Release Inhibiting Factor CAS NO.39705-60-7](https://images.cnmqh.com/images/a10134/fd8351357b28a4947aeba4abf97b80db-20260129063057.webp "[D-Leu2]-Melanocyte-Stimulating Hormone-Release Inhibiting Factor CAS NO.39705-60-7")
[D-Leu2]-Melanocyte-Stimulating Hormone-Release Inhibiting Factor CAS NO.39705-60-7
[D-Leu2]-Melanocyte-Stimulating Hormone-Release Inhibiting Factor CAS NO.39705-60-7
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [D-Leu2]-Melanocyte-Stimulating Hormone-Release Inhibiting Factor |
| CAS NO. | 39705-60-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C13H24N4O3 |
| Molecular Weight | 284.36g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | It is soluble in water, physiological saline or dilute acetic acid solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | This product is an analogue of melanocyte-stimulating hormone-releasing inhibitory factor (MIF). D-Leu2 modification enhances enzyme stability and bioavailability, and it can inhibit the release or activity of α-MSH. Its bioactivity needs to be verified through in vitro melanocyte inhibition experiments or related receptor function experiments. |
| Storage Conditions | Freeze-dried powder should be stored at -20°C or lower in a dry, light-protected environment; reconstituted solutions should be aliquoted and stored at ≤-20°C, avoiding repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The mechanism of action involves inhibition of melanocyte-stimulating hormone (MSH) release and/or antagonism of MSH activity at its receptors. The peptide likely acts through interaction with specific receptors or regulatory pathways in the hypothalamus or pituitary that control MSH secretion, potentially modulating the release of α-MSH and other melanocortins. The D-leucine substitution at position 2 enhances resistance to enzymatic degradation, prolonging the peptide's half-life and increasing its inhibitory potency compared to the native MIF sequence. This enhanced stability allows for more sustained suppression of MSH-mediated effects, making it a more effective research tool for studying the regulation of melanogenesis and related physiological processes.
2.PRODUCT INDICATIONS
This MIF analog is indicated for research use only in preclinical studies investigating the regulation of melanocyte-stimulating hormone release, melanogenesis mechanisms, skin pigmentation disorders, and neuroendocrine control of pigmentation. It serves as a potent inhibitor in studies examining MSH secretion, melanin synthesis assays, and animal models of hyperpigmentation or pigmentary disorders. The product is also used in structure-activity relationship studies to understand peptide-receptor interactions and in the development of compounds targeting MSH regulation. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals, and should be handled by trained research personnel in appropriate laboratory settings.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, [D-Leu2]-Melanocyte-Stimulating Hormone-Release Inhibiting Factor does not have established clinical efficacy for therapeutic use in human patients. While this peptide analog and related compounds have been studied in preclinical models to understand MSH regulation and potential applications in pigmentary disorders, the product itself has not undergone clinical development or received regulatory approval for any medical indication. Research using this peptide has contributed to the understanding of melanocortin regulatory pathways, but the product remains an investigational research tool without proven clinical efficacy or safety profile for human use.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight
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