Fmoc-Gly-Arg(Pbf)-OH CAS NO.660846-80-0
Fmoc-Gly-Arg(Pbf)-OH CAS NO.660846-80-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Fmoc-Gly-Arg(Pbf)-OH |
| CAS NO. | 660846 - 80 - 0 |
| Appearance | White to off-white powder |
| Molecular Formula | C₂₅H₃₀N₄O₆ |
| Molecular Weight | 498.53 g/mol |
| Amino Acid Sequence | Fmoc - Gly - Arg(Pbf) |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMF, DMSO, and slightly soluble in water. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Suitable for peptide synthesis applications; can be used as a building block in the construction of biologically active peptides. |
| Storage Conditions | Store at - 20°C in a dry and dark place. Protect from moisture and light. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Fmoc-Gly-Arg(Pbf)-OH is a protected amino acid derivative used extensively in solid-phase peptide synthesis (SPPS). The Fmoc (9-Fluorenylmethyloxycarbonyl) group protects the N-terminus of glycine, preventing unwanted side reactions during coupling steps. The Pbf (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl) group protects the guanidino group of arginine, ensuring chemoselectivity during peptide elongation.
During synthesis, the Fmoc group is removed under mild basic conditions (e.g., piperidine in DMF), exposing the free amine for coupling with the next amino acid. The Pbf protecting group remains intact until final global deprotection (typically with strong acids like TFA), allowing precise control over peptide sequence and purity. This protection/deprotection mechanism minimizes racemization and maximizes coupling efficiency, yielding high-quality peptides for research and pharmaceutical applications.
2.PRODUCT INDICATIONS
Primary Synthetic Target:
Used as a building block for custom peptide synthesis in research, drug discovery, and biopharmaceutical manufacturing.
Peptide Synthesis Applications:
Incorporation into peptides requiring glycine-arginine sequences, such as antimicrobial peptides, enzyme substrates, and receptor ligands.
Ideal for synthesizing structurally complex peptides where arginine side-chain protection is critical.
Research & Development Uses:
Preclinical studies exploring peptide structure-activity relationships (SAR).
Production of labeled or modified peptides for analytical and diagnostic assays.
Industrial Applications:
Manufacturing of peptide APIs (Active Pharmaceutical Ingredients), cosmetics peptides, and functional food ingredients.
3.CLINICAL EFFICACY OF PRODUCT
Synthesis Efficiency:
Coupling yields >95% reported in SPPS protocols using this protected fragment, reducing synthesis time and impurity formation.
Purity & Quality:
RP-HPLC purity typically ≥98%, ensuring reliable downstream peptide quality.
Minimal residual solvents and protecting-group content post-deprotection, compliant with pharmacopoeia standards.
Stability:
Stable under recommended storage (−20 °C, dry, inert atmosphere), with shelf life exceeding 24 months when properly sealed.
Scalability:
Successfully employed in both milligram-scale laboratory synthesis and multi-kilogram production runs for clinical peptide candidates.
Safety Profile:
Non-toxic under standard laboratory handling; routine PPE (gloves, goggles) advised due to organic solvent exposure during synthesis.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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